ChemicalBook > CAS DataBase List > JNJ-10198409

JNJ-10198409

Product Name
JNJ-10198409
CAS No.
627518-40-5
Chemical Name
JNJ-10198409
Synonyms
RWJ 540973;JNJ-10198409;JNJ-10198409, Free Base;JNJ-10198409 (JNJ10198409);JNJ-10198409 >=98% (HPLC), solid;PDGFR Tyrosine Kinase Inhibitor IV;JNJ-10198409 (This product is only available in Japan.);PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem;N-(3-Fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine
CBNumber
CB3972168
Molecular Formula
C18H16FN3O2
Formula Weight
325.34
MOL File
627518-40-5.mol
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JNJ-10198409 Property

Melting point:
171-173.5 °C
Boiling point:
528.8±50.0 °C(Predicted)
Density 
1.366±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: >10mg/mL
form 
solid
pka
14.01±0.20(Predicted)
color 
off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
J4649
Product name
JNJ-10198409
Purity
≥98% (HPLC), solid
Packaging
1mg
Price
$240
Updated
2024/03/01
Sigma-Aldrich
Product number
521233
Product name
PDGFR Tyrosine Kinase Inhibitor IV
Packaging
1mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
10008131
Product name
JNJ-10198409
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
10008131
Product name
JNJ-10198409
Purity
≥98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Sigma-Aldrich
Product number
J4649
Product name
JNJ-10198409
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$863
Updated
2023/01/07
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JNJ-10198409 Chemical Properties,Usage,Production

Biological Activity

jnj-10198409 is a small molecule inhibitor of platelet-derived growth factor (pdgf-bb) tyrosine kinase [1].platelet-derived growth factor (pdgf) is a ubiquitous mitogen involved in regulating cell growth and division, embryonic development, cell proliferation, cell migration, and angiogenesis. overexpression of pdgf has been associated with several diseases such as atherosclerosis, fibrotic disorders and malignancies. inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (pdgf-bb) receptor can have potent antiangiogenic and antiproliferative activity. recombinant pdgf is used in medicine to help heal chronic ulcers and in orthopedic surgery and periodontistry to treat bone loss [2].in human coronary artery smooth muscle cells, jnj-10198409 inhibited the activity of platelet-derived growth factor (pdgf-bb) tyrosine kinase with an ic50 value of 4.2 nm when tested. jnj-10198409 was a competitive antagonist of the atp binding and hydrolysis at pdgf-bb receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis [1].

storage

Store at -20°C

References

[1] ho c y, ludovici d w, maharoof u s m, et al. (6, 7-dimethoxy-2, 4-dihydroindeno [1, 2-c] pyrazol-3-yl) phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells[j]. journal of medicinal chemistry, 2005, 48(26): 8163-8173.
[2] raines e w, bowen-pope d f, ross r. platelet-derived growth factor[m]//peptide growth factors and their receptors i. springer berlin heidelberg, 1990: 173-262.

JNJ-10198409 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ-10198409 Suppliers

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627518-40-5, JNJ-10198409Related Search:

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  • PDGFR Tyrosine Kinase Inhibitor IV
  • JNJ-10198409 (This product is only available in Japan.)
  • N-(3-Fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
  • JNJ-10198409
  • Indeno[1,2-c]pyrazol-3-amine, N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-
  • RWJ 540973, 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine
  • JNJ-10198409, Free Base
  • 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine
  • N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine
  • RWJ 540973
  • JNJ-10198409 (JNJ10198409)
  • PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem
  • JNJ-10198409 >=98% (HPLC), solid
  • Platelet-derived growth factor receptor,JNJ-10198409,inhibit,Inhibitor,JNJ 10198409,JNJ10198409,PDGFR
  • 627518-40-5