Dexamethasone
Anti-inflammatory effects Description Side Effects Drug Reactions- Product Name
- Dexamethasone
- CAS No.
- 50-02-2
- Chemical Name
- Dexamethasone
- Synonyms
- DEXAMETHASONE BASE;DXM;DEXAMETHASON;Dexa;Dexametasona;DECADRON;HEXADECADROL;Dexamethazone;DexaMethasone-d4;DEXAMETHASONE CRYSTALLINE
- CBNumber
- CB4261243
- Molecular Formula
- C22H29FO5
- Formula Weight
- 392.47
- MOL File
- 50-02-2.mol
Dexamethasone Property
- Melting point:
- 262-264 °C (lit.)
- alpha
- 75 º (c=1, dioxane)
- Boiling point:
- 568.2±50.0 °C(Predicted)
- Density
- 1.1283 (estimate)
- refractive index
- 76 ° (C=1, Dioxane)
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- ethanol: 1 mg/mL
- form
- powder
- pka
- 12.13±0.70(Predicted)
- color
- off-white
- biological source
- synthetic (organic)
- Water Solubility
- 10 mg/100 mL (25 ºC)
- Sensitive
- Light Sensitive
- Merck
- 14,2943
- BRN
- 2066651
- BCS Class
- 1 (CLogP), 3 (LogP)
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
- InChIKey
- UREBDLICKHMUKA-CXSFZGCWSA-N
- CAS DataBase Reference
- 50-02-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2)
- EPA Substance Registry System
- Dexamethasone (50-02-2)
Safety
- Hazard Codes
- Xi,Xn,T,F
- Risk Statements
- 43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11
- Safety Statements
- 36/37-45-36-26-22-16
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 2
- RTECS
- TU3980000
- TSCA
- Yes
- HS Code
- 29372210
- Hazardous Substances Data
- 50-02-2(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: > 3gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0001593
- Product name
- Dexamethasone for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001593
- Price
- $220
- Updated
- 2024/03/01
- Product number
- Y0001177
- Product name
- Dexamethasone for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001177
- Price
- $220
- Updated
- 2024/03/01
- Product number
- D1756
- Product name
- Dexamethasone
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $36.2
- Updated
- 2024/03/01
- Product number
- D2915
- Product name
- Dexamethasone-Water Soluble
- Purity
- suitable for cell culture, BioReagent
- Packaging
- 100MG
- Price
- $192
- Updated
- 2024/03/01
- Product number
- D-085
- Product name
- Dexamethasone solution
- Purity
- 1.0?mg/mLinmethanol,ampuleof1?mL,certifiedreferencematerial,Cerilliant?
- Packaging
- 1mL
- Price
- $87
- Updated
- 2024/03/01
Dexamethasone Chemical Properties,Usage,Production
Anti-inflammatory effects
Dexamethasone reduces and prevents the tissue response to inflammation, thereby reducing the manifestations of inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at sites of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators.
Description
Dexamethasone is an Anti-inflammatory glucocorticoid that is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide.
Dexamethasone induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cd k2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils in vitro. Dexamethasone is an activator of IDO.
Dexamethasone Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50=5 nM). Dexamethasone regulates T cell survival, growth, and differentiation.Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C.
Side Effects
Dexamethasone is a artificially synthetic glucocorticoid, belonging to a long-term glucocorticoid drugs. Glucocorticoids can promote the metabolism of the three major nutrients while preventing protein synthesis with long-term topical being able to causing more serious consequences. However, the adverse effects should be much smaller than oral medication. Common side effects of systemic corticosteroid include:
It can cause stomach discomfort and increased sensitivity to stomach ulcers.
It can Increase the appetite and results in a significant increase in body weight.
Potential patients with diabetes: glucose intolerance in patients with aggravating existing diabetes.
It can cause mental illness including personality changes, irritability, agitation, and mania.
It can be used for the long-term treatment of osteoporosis: pathological fractures (such as hip).
It can cause elevated liver enzymes, fatty liver degeneration (usually reversible).
For patients of nephrotic syndrome, applying long-term high-dose medication is likely to cause large side effects such as gastrointestinal ulcers and avascular necrosis. For treatment of nephrotic syndrome, it is better to apply prednisone acetate tablets.
Dexamethasone can be used for the treatment of high altitude cerebral edema and pulmonary edema. Upon climbing expeditions, people can apply it to alleviate altitude sickness.
Combination with marbofloxacin and clotrimazole, etc. can be used for treating the ear infection and allergies of a dog or a bird.
The above information is edited by the chemicalbook of Dai Xiongfeng.
Drug Reactions
Dexamethasone is a corticosteroid known as a glucocorticoid. Corticosteroids are meant to resemble a naturally occurring hormone produced in the adrenal cortex, cortisol. Corticosteroids act on the immune system by blocking the production of substances that trigger inflammatory and immune responses.
Dexamethasone may react with these drugs:
Amphotericin
Aspirin
Cyclophosphamide
Cyclosporine
Digoxin
Daunorubicin HCl
Doxorubicin HCl
Insulin
Mitotane
Phenobarbital
Phenytoin sodium
Rifampin
Rimadyl
Description
The activity of dexamethasone, as measured by glycogen deposition, is 20 times greater than that of hydrocortisone. It has five times the anti-inflammatory activity of prednisolone. Clinical data indicate that this compound has seven times the antirheumatic potency of prednisolone. It is roughly 30 times more potent than hydrocortisone. Its pharmacokinetics are presented in Table 33.3. Routes of metabolism for dexamethasone are similar to those for prednisolone, with its primary 6β-hydroxy metabolite being recovered in urine. Dexamethasone sodium phosphate is the water-soluble sodium salt of the 21-phosphate ester, with an IV half-life of less than 10 minutes because of rapid hydrolysis by plasma phosphatases. Peak plasma levels for dexamethasone usually are attained in approximately 10 to 20 minutes following its IV administered dose. A similar reaction occurs when the phosphate ester is applied topically or by inhalation.
Chemical Properties
White or almost white, crystalline powder.
Originator
Dexacen,Central,US,1977
Uses
Dexamethasone is used for the same indications as all corticosteroids; however, it exhibits a significantly more powerful anti-inflammatory and anti-allergic action. It is used for circulatory collapse—shock during or after surgical operations, trauma, blood loss, myocardial infarction, and burns. It is also used in severe infections—toxemia, vascular collapse in meningococcosis, septicemia, diphtheria, typhoid fever, and peritonitis. It is used in severe allergic conditions—asthmatic status, laryngeal edema, severe anaphylactic reactions to medicinal drugs, and pyrogenic reactions.
Uses
Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.
Indications
Cushing’s disease is defined as hypercortisolism due to chronic overproduction of corticotrophin by a corticotroph adenoma. Cortisol’s lack of suppressibility during the administration of low doses of dexamethasone but suppressibility during high-dose dexamethasone is the key diagnostic finding in 99% of the patients with Cushing’s disease. This contrasts with the lack of glucocorticoid suppressibility typically found in patients with corticotrophin-independent hypercortisolism (Cushing’s syndrome). A judicious selection of the available tests may be necessary to obtain an accurate diagnosis in patients with Cushing’s syndrome.
Definition
ChEBI: Dexamethasone is a fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids. It has a role as an adrenergic agent, an antiemetic, an antineoplastic agent, an environmental contaminant, a xenobiotic, an immunosuppressive agent and an anti-inflammatory drug. It is a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a glucocorticoid, a 20-oxo steroid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid and a 21-hydroxy steroid. It derives from a hydride of a pregnane.
Manufacturing Process
The preparation of dexamethasone acetate is described in US Patent
3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous
hydrofluoric acid are admixed and treated with 480 mg of 9β,11β-epoxy-17αhydroxy-21-acetoxy-16α-methyl-?1,4-pregnadiene-3,20-dione (prepared
according to E.P. Oliveto et al, J. Am. Chem. Soc., 80, 44331, 1958). The
steroid dissolves in about 15 minutes. The reaction mixture is shaken for two
hours at a temperature between 0 and +5°C, and then poured into 75 cc of
water containing in suspension, 7.5 grams of sodium bicarbonate. The mixture
is vacuum filtered, the filter cake washed and then dried at 100°C, yielding
460 mg of crude hexadecadrol contaminated with a small amount of the
starting material. A single recrystallization from methylene chloride yields 370
mg of the pure product having a melting point of 170°C and 229°C. The
mother liquor yields 62 mg of the starting material, and a remainder
constituting a mixture of starting and final materials with little other
contamination.
brand name
Aeroseb-Dex (Allergan); Decadron (Merck); Dexone (Solvay Pharmaceuticals); Hexadrol (Organon); Maxidex (Alcon); Mymethasone (Morton Grove).
Therapeutic Function
9-Fluoro-11β,17-dihydroxy-21-acetoxy-16α-methylpregna1,4-diene-3,20-dione
General Description
Dexamethasone, 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione,is the 16 -isomer of betamethasone.
Dexamethasone acetate, USP (21-acetate)
Dexamethasone sodium phosphate, USP (21-sodiumphosphate).
General Description
Odorless white to off-white crystalline powder with a slightly bitter taste.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Dexamethasone may be sensitive to prolonged exposure to light. Dexamethasone is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases.
Fire Hazard
Flash point data for Dexamethasone are not available; however, Dexamethasone is probably combustible.
Biological Activity
Glucocorticoid; anti-inflammatory. Reduces levels of activated NF- κ B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs.
Biochem/physiol Actions
Target IC50: 5 nM Inhibiting the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells
Pharmacology
Dexamethasone is a corticosteroid with high glucocorticoid activity and virtually no mineralocorticoid activity. I ts mechanism of action as an antiemetic is unknown, but it is possible that either direct genomic or indirect non-genomic effects on 5-HT3 and GABAA receptors contribute to its antiemetic activity. Many of the original studies were carried out using 8– 10mg of dexamethasone phosphate, but smaller doses (2.5–4mg) provide equal antiemetic efficacy with minimal risk of adverse effects. Concerns relating to adrenal suppression and other steroid-induced adverse effects (including increased risk of bleeding) after a single dose of dexamethasone remain largely unfounded. O ne of the most unpleasant adverse effects of dexamethasone involves intense perineal stimulation after rapid i.v. injection.
Pharmacokinetics
The activity of dexamethasone, as measured by glycogen deposition, is 20 times greater than that of hydrocortisone. It has five times the anti-inflammatory activity of prednisolone. Clinical data indicate that this compound has seven times the antirheumatic potency of prednisolone. It is roughly 30 times more potent than hydrocortisone. Its pharmacokinetics are presented in Table 33.3. Routes of metabolism for dexamethasone are similar to those for prednisolone, with its primary 6β-hydroxy metabolite being recovered in urine. Dexamethasone sodium phosphate is the water-soluble sodium salt of the 21-phosphate ester, with an IV half-life of less than 10 minutes because of rapid hydrolysis by plasma phosphatases. Peak plasma levels for dexamethasone usually are attained in approximately 10 to 20 minutes following its IV administered dose. A similar reaction occurs when the phosphate ester is applied topically or by inhalation.
Clinical Use
Corticosteroid:
Cerebral oedema
Bacterial meningitis (unlicensed indication)
Suppression of inflammatory and allergic disorders
Rheumatic disease
Congenital adrenal hyperplasia
Anti-emetic (unlicensed indication)
Safety Profile
Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of F-.
Synthesis
Dexamethasone, 9|á-fluoro-16|á-methyl-11|?,17,21-trihydroxypregna-
1,4-dien-3,20-dione (27.1.51), or simply 9|á-fluoro-16|á-methylprednisolone. The distinctive
characteristic of dexamethasone is the presence of a fluorine atom at C9 of the steroid
ring.
Dexamethasone is synthesized in a multistage process from 3|á-acetoxy-16-pregnen-
11,20-dione, which is reacted with methylmagnesium bromide in the presence of lithium
bromide to give 3|á-hydroxy-16|á-methylpregnan-11,20-dione (27.1.39), after which a 17|á-
hydroxyl group is added. This is done by a reaction with acetic anhydride in the presence of
p-toluenesulfonic acid, forming the 3-acetoxy-17-enolacetate 27.1.40, which is epoxidized
by perbenzoic acid 27.1.41, and the product is hydrolyzed by an alkali to give an oxyketone
27.1.42. Addition of another hydroxyl group at C21 is accomplished by subsequent bromination
of a methyl group with molecular bromine, replacing the bromine atom with iodine, and
reacting iodide with potassium acetate, which forms the corresponding acetoxyketone
27.1.43. The hydroxyl group at C3 is oxidized to a carbonyl by chromium(VI) oxide in pyridine,
giving the 3,11,20-triketone 27.1.44, which again undergoes bromination by molecular
bromine, but at position C4. Dehydrogenation of this compound is accomplished using semicarbazide,
which results in the formation of an unsaturated triketone 27.1.45. In order to
avoid formation of semicarbazones at the keto-groups at C3 and C20, the final product is
treated with pyruvic acid. Semicarbazones are then specially formed at the keto-groups of C3
and C20, and the keto-group at C11 that does not take part in semicarbazone formation is
reduced to hydroxyl group using sodium borohydride. After removing the protective semicarbzone
groups, 21-O-acetoxy-16|?-methylhydrocortisone (27.1.46) is formed. This is
reacted with potassium acetate and transformed to the epoxide 27.1.49. Reacting this with
hydrofluoric acid results in an opening of the epoxide ring, during which the fluorohydrin
27.1.50 is formed. Finally, microbiological dehydrogenation of this compound at C1¨CC2 and
simultaneous deacetylation gives dexamethasone (27.1.51).
Veterinary Drugs and Treatments
Glucocorticoids have been used in an attempt to treat practically
every malady that afflicts man or animal, but there are three broad
uses and dosage ranges for use of these agents. 1) Replacement of
glucocorticoid activity in patients with adrenal insufficiency, 2) as an
antiinflammatory agent, and 3) as an immunosuppressive. Among
some of the uses for glucocorticoids include treatment of: endocrine
conditions (e.g., adrenal insufficiency), rheumatic diseases (e.g.,
rheumatoid arthritis), collagen diseases (e.g., systemic lupus), allergic
states, respiratory diseases (e.g., asthma), dermatologic diseases
(e.g., pemphigus, allergic dermatoses), hematologic disorders (e.g.,
thrombocytopenias, autoimmune hemolytic anemias), neoplasias,
nervous system disorders (increased CSF pressure), GI diseases (e.g.,
ulcerative colitis exacerbations), and renal diseases (e.g., nephrotic
syndrome). Some glucocorticoids are used topically in the eye and
skin for various conditions or are injected intra-articularly or intralesionally.
The above listing is certainly not complete. For specific
dosages and indications refer to the Doses section.
High dose dexamethasone use for shock or CNS trauma is controversial;
recent studies have not demonstrated significant benefit
and it actually may cause increased deleterious effects.
Drug interactions
Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifamycins;
metabolism possibly inhibited by erythromycin;
concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and
phenindione may be altered.
Antiepileptics: metabolism accelerated by
carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone
Antifungals: increased risk of hypokalaemia with
amphotericin - avoid; metabolism possibly inhibited
by itraconazole and ketoconazole; caspofungin
concentration possibly reduced (may need to increase
dose).
Antivirals: concentration of indinavir, lopinavir,
saquinavir and telaprevir possibly reduced; avoid
with rilpivirine; concentration possibly increased by
ritonavir.Ciclosporin: rare reports of convulsions in patients
on ciclosporin and high-dose corticosteroids.
Cobicistat: concentration possibly increased by
cobicistat.
Cytotoxics: possibly decreases axitinib concentration,
increase dose of axitinib.
Diuretics: enhanced hypokalaemic effects of
acetazolamide, loop diuretics and thiazide diuretics.
Netupitant: concentration of dexamethasone
increased - halve dexamethasone dose.
Vaccines: high dose corticosteroids can impair
immune response to vaccines; avoid concomitant use
with live vaccines.
Metabolism
Corticosteroids are metabolised mainly in the liver but also in other tissues, and are excreted in the urine. The slower metabolism of the synthetic corticosteroids with their lower protein-binding affinity may account for their increased potency compared with the natural corticosteroids. Up to 65% of a dose of dexamethasone is excreted in urine within 24 hours.
storage
-20°C (protect from light)
Purification Methods
Dexamethasone has been recrystallised from Et2O or small volumes of EtOAc. Its solubility in H2O is 10 mg/100mL at 25o; and is freely soluble in Me2CO, EtOH and CHCl3. [Arth et al. J Am Chem Soc 80 3161 1958; for the -methyl isomer see Taub et al. J Am Chem Soc 82 4025 1960, see Beilstein 8 IV 3501.]
References
1) Merck Index 14 2943
Dexamethasone Preparation Products And Raw materials
Raw materials
Preparation Products
Dexamethasone Suppliers
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View Lastest Price from Dexamethasone manufacturers
- Product
- Dexamethasone 50-02-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20
- Release date
- 2025-03-12
- Product
- Dexamethasone 50-02-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%
- Supply Ability
- 1tons
- Release date
- 2024-04-26
- Product
- Dexamethasone 50-02-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000
- Release date
- 2025-03-24