ChemicalBook > CAS DataBase List > SR8278
SR8278
- Product Name
- SR8278
- CAS No.
- 1254944-66-5
- Chemical Name
- SR8278
- Synonyms
- SR8278;SR8278;SR-8278;SR 8278;UIEBLUZPSFAFOC-UHFFFAOYSA-N;ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate;Ethyl 2-(5-(methylthio)thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate;Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate;1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester;Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
- CBNumber
- CB42628428
- Molecular Formula
- C18H19NO3S2
- Formula Weight
- 361.48
- MOL File
- 1254944-66-5.mol
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SR8278 Property
- Melting point:
- 52-55°C
- Boiling point:
- 535.7±50.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥30mg/mL
- pka
- -3.20±0.40(Predicted)
- form
- film
- color
- white to tan
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S9576
- Product name
- SR8278
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- S9576
- Product name
- SR8278
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $387.6
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17000
- Product name
- SR8278
- Purity
- ≥90%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17000
- Product name
- SR8278
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17000
- Product name
- SR8278
- Purity
- ≥90%
- Packaging
- 10mg
- Price
- $201
- Updated
- 2024/03/01
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SR8278 Chemical Properties,Usage,Production
Description
REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.
Uses
SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.
storage
Store at +4°C
SR8278 Preparation Products And Raw materials
Raw materials
Preparation Products
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SR8278 Suppliers
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