ChemicalBook > CAS DataBase List > SR8278

SR8278

Product Name
SR8278
CAS No.
1254944-66-5
Chemical Name
SR8278
Synonyms
SR8278;SR8278;SR-8278;SR 8278;UIEBLUZPSFAFOC-UHFFFAOYSA-N;ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate;Ethyl 2-(5-(methylthio)thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate;Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate;1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester;Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
CBNumber
CB42628428
Molecular Formula
C18H19NO3S2
Formula Weight
361.48
MOL File
1254944-66-5.mol
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SR8278 Property

Melting point:
52-55°C
Boiling point:
535.7±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥30mg/mL
pka
-3.20±0.40(Predicted)
form 
film
color 
white to tan
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S9576
Product name
SR8278
Purity
≥98% (HPLC)
Packaging
5mg
Price
$161
Updated
2024/03/01
Sigma-Aldrich
Product number
S9576
Product name
SR8278
Purity
≥98% (HPLC)
Packaging
25mg
Price
$387.6
Updated
2024/03/01
Cayman Chemical
Product number
17000
Product name
SR8278
Purity
≥90%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17000
Product name
SR8278
Purity
≥90%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
17000
Product name
SR8278
Purity
≥90%
Packaging
10mg
Price
$201
Updated
2024/03/01
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SR8278 Chemical Properties,Usage,Production

Description

REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.

Uses

SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.

storage

Store at +4°C

SR8278 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR8278 Suppliers

Canada 1 China 72 United Kingdom 2 United States 12 USA 1 Global 88

1254944-66-5, SR8278Related Search:

2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide 4-Quinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- NA SR-717 SRT3025 SR9009 SR19881 SR-9243 SRPK inhibitor SR 1078 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide SRI 31215 SR27897 SR17018 N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine SR 0987 SR-4835 SR18662

  • SR8278
  • 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
  • UIEBLUZPSFAFOC-UHFFFAOYSA-N
  • SR8278;SR-8278;SR 8278
  • ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate
  • Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate
  • 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester
  • Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
  • Ethyl 2-(5-(methylthio)thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
  • 1254944-66-5
  • 125944-66-5
  • 123456