Desoxycorticosterone

Product Name: Desoxycorticosterone
CAS No.: 64-85-7
Chemical Name: Desoxycorticosterone
Synonyms: DOC;CORTEXONE;Corthormon;Deoxycortone;Desoxycorton;DOC【steroid】;DESOXYCORTONE;'REICHSTEIN Q';DEOXYCORTICOSTERONE;DESOXYCORTICOSTERONE
CBNumber: CB4314147
Molecular Formula: C21H30O3
Formula Weight: 330.46
MOL File: 64-85-7.mol

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Desoxycorticosterone Property

Melting point:: 138-144 °C
alpha: 184 º (c=1, C2H5OH)
Boiling point:: 407.89°C (rough estimate)
Density: 1.0998 (rough estimate)
refractive index: 1.5192 (estimate)
Flash point:: 9℃
storage temp.: -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.98±0.10(Predicted)
form: Solid
color: White to Pale Yellow
optical activity: +17822 (c 1.5, ethanol)
Water Solubility: slightly soluble
Merck: 13,2917
BRN: 2062123
LogP: 2.880
CAS DataBase Reference: 64-85-7(CAS DataBase Reference)
NIST Chemistry Reference: Deoxycorticosterone(64-85-7)
EPA Substance Registry System: Deoxycorticosterone (64-85-7)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 40-48-39/23/24/25-23/24/25-11
Safety Statements: 22-24/25-45-36/37-16-7
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: HG0350000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D6875
Product name: 21-Hydroxyprogesterone
Purity: ≥97% (HPLC)
Packaging: 1g
Price: $386
Updated: 2024/03/01

Sigma-Aldrich

Product number: D-105
Product name: 11-Deoxycorticosterone solution
Purity: 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $128
Updated: 2024/03/01

Cayman Chemical

Product number: 22916
Product name: 11-deoxy Corticosterone
Purity: ≥95%
Packaging: 25mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 22916
Product name: 11-deoxy Corticosterone
Purity: ≥95%
Packaging: 50mg
Price: $101
Updated: 2024/03/01

Sigma-Aldrich

Product number: D6875
Product name: 21-Hydroxyprogesterone
Purity: ≥97% (HPLC)
Packaging: 500mg
Price: $221
Updated: 2024/03/01

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Desoxycorticosterone Chemical Properties,Usage,Production

Chemical Properties

white to creamy-white crystalline powder

Uses

A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).

Uses

Antiinflammatory;Corticoide

Definition

ChEBI: A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.

General Description

11-Deoxycorticosterone is a steroid hormone produced in the adrenal glands that acts as a precursor for the hormone aldosterone. Levels of 11-deoxycorticosterone are measured by LC-MS/MS to aid in diagnosing disorders of steroid synthesis, such as 11-hydroxylase deficiency and glucocorticoid responsive hyperaldosteronism. This Certified Spiking Solution^? is suitable for use as starting material inlinearity standards, calibrators, and controls for numerous LC-MS/MS applications in endocrinology, clinical chemistry, and neonatal screening.

Hazard

Toxic.

Mechanism of action

Desoxycorticosterone causes an increase in reabsorption of sodium ions and excretion of potassium ions from the renal tubules, which leads to increased tissue hydrophilicity. This facilitates an elevated volume of plasma and increased arterial pressure. Muscle tonicity and work capability are increased. It is used for an insufficiency of function of the adrenal cortex, myasthenia, asthenia, adynamia, and overall muscle weakness.

Synthesis

Desoxycorticosterone, 21-hydroxypregn-4-en-3,20-dione acetate (27.2.6), is synthesized in a number of ways, the easiest of which being iodination of progesterone at C21 in the methyl group, and subsequent reaction of the resulting iodo-derivative 27.2.5 with potassium acetate, which leads to formation of the desired desoxycorticosterone in the form of the acetate (27.2.6) .

Purification Methods

Crystallise 11-deoxycorticosterone from diethyl ether. [Schindler et al. Helv Chim Acta 24 360 1941, Steiger & Reichstein Helv Chim Acta 20 1164 1937.]

Desoxycorticosterone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Desoxycorticosterone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Desoxycorticosterone 64-85-7
Price: US $0.00-0.00/mg
Min. Order: 1mg
Purity: 98%
Supply Ability: 10g/month
Release date: 2023-02-17

64-85-7, DesoxycorticosteroneRelated Search:

Chenodeoxycholic acid CORTICOSTERONE Ursodeoxycholic acid Doxifluridine D-METHAMPHETAMINE REICHSTEIN'S SUBSTANCE S 21-ACETATE 4-PREGNEN-6-BETA, 17,21-TRIOL-3,11,20-TRIONE Hydrocortisone Hydrocortisone acetate Cortisone acetate Flurandrenolide CORTISONE 11-DEHYDROCORTICOSTERONE Hydrocortisone 21-hemisuccinate (-)-2-[METHYLAMINO]-1-PHENYLPROPANE Hydrocortisone sodium succinate desoxycorticosterone-21-acetat DESOXYCORTICOSTERONE PROPIONATE

Corthormon

Corticosterone, 11-deoxy-

Deoxycortone

Pregn-4-en-21-ol-3,20-dione

Pregn-4-ene-3,20-dione, 21-hydroxy-

Progesterone, 21-hydroxy-

deoxycorticosterone crystalline

Desoxycorton

21-HYDROXYPROGESTERON VETRANAL, 250 MG

17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

HYDROXYPROGESTERONE, 21-(RG)

Reichstein Q, 11-Deoxycorticosterone, 11-Desoxycorticosterone, 21-Hydroxy-4-pregnene-3,20-dione, 4-Pregnen-21-ol-3,20-dione, Cortexone, Desoxycortone, DOC, Kendalls desoxy compound B

Deoxycorticosterone Propionate

DOC【steroid】

DesoxycorticosteroneDeoxycorticosterone

21-Hydroxy-3,20-dioxopregn -4-ene

21-Hydroxy-4-pregnane-3,20-dione

CORTEXONE

DELTA4-PREGNEN-21-OL-3,20-DIONE

DEOXYCORTICOSTERONE

DESOXYCORTICOSTERONE

DESOXYCORTONE

DOC

HYDROXYPROGESTERONE, 21-

KENDALL'S DESOXY COMPOUND B

4-PREGNENE-21-OL-3,20-DIONE

4-PREGNEN-21-OL-3,20-DIONE

11-DESOXYCORTICOSTERONE

11-DEOXYCORTICOSTERONE

21-HYDROXY-4-PREGNENE-3,20-DIONE

21-hydroxypregn-4-ene-3,20-dione

21-HYDROXYPROGESTERONE

'REICHSTEIN Q'

REICHSTEIN'S COMPOUND ''Q''

REICHSTEIN'S SUBSTANCE Q

(8S,10R,13S,17S)-17-(2-Hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

11-Dehydroxycorticosterone

21-Hydroxypregn-4-en-3,20-dione

21-hydroxy-progesteron

Desoxycorticosterone Solution, 100ppm

11-Deoxycorticosterone solution

Corticosterone Impurity 5

11-Deoxycorticosterone-2,3,4-13C3 solution 100 mug/mL in methanol, >=99 atom % 13C, >=98% (CP)

Desoxycorticosterone USP/EP/BP

21-hydroxyprogesteroneQ: What is 21-hydroxyprogesterone Q: What is the CAS Number of 21-hydroxyprogesterone Q: What is the storage condition of 21-hydroxyprogesterone

2H6]-Deoxycorticosterone

2H4]-11-Deoxycorticosterone

64-85-7

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Steroids