ChemicalBook > CAS DataBase List > 2-Chloro-4-pyridinecarboxylic acid

2-Chloro-4-pyridinecarboxylic acid

Product Name
2-Chloro-4-pyridinecarboxylic acid
CAS No.
6313-54-8
Chemical Name
2-Chloro-4-pyridinecarboxylic acid
Synonyms
2-CHLOROISONICOTINIC ACID;2-CHLOROPYRIDINE-4-CARBOXYLIC ACID;NSC 40139;BUTTPARK 43\57-03;RARECHEM AL BO 0840;TIMTEC-BB SBB004003;2-Chloroisonicotinic;2-Chloro-4-pyridinec;ChloroisonicotinicAcid;oropyridine-4-carboxyL
CBNumber
CB4375001
Molecular Formula
C6H4ClNO2
Formula Weight
157.55
MOL File
6313-54-8.mol
More
Less

2-Chloro-4-pyridinecarboxylic acid Property

Melting point:
246 °C (dec.)(lit.)
Boiling point:
417.7±25.0 °C(Predicted)
Density 
1.470±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
pka
3.00±0.10(Predicted)
form 
Crystalline Powder
color 
White to beige
BRN 
115861
InChI
InChI=1S/C6H4ClNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10)
InChIKey
QXCOHSRHFCHCHN-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(C(O)=O)=C1
CAS DataBase Reference
6313-54-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-36/37/39
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
543918
Product name
2-Chloropyridine-4-carboxylic acid
Purity
97%
Packaging
5g
Price
$28.1
Updated
2025/07/31
Sigma-Aldrich
Product number
543918
Product name
2-Chloropyridine-4-carboxylic acid
Purity
97%
Packaging
25g
Price
$101
Updated
2023/06/20
TCI Chemical
Product number
C1368
Product name
2-Chloroisonicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$39
Updated
2025/07/31
TCI Chemical
Product number
C1368
Product name
2-Chloroisonicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$118
Updated
2025/07/31
TRC
Product number
C367375
Product name
2-Chloroisonicotinic Acid
Packaging
1g
Price
$45
Updated
2021/12/16
More
Less

2-Chloro-4-pyridinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white crystall powder

Uses

Used in monocomposite films.

Synthesis

33252-30-1

6313-54-8

General procedure for the synthesis of 2-chloroisonicotinic acid from 2-chloro-4-cyanopyridine: 2-chloro-4-cyanopyridine (2 mmol) was dissolved in 5 ml of [bmim]HSO4, and the reaction mixture was heated for 1-3 hours at 60-65 °C. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was poured into water containing crushed ice and the product precipitated as a precipitate. The precipitate was collected by filtration and dried. High yields (>90%) of 2-chloroisonicotinic acid were obtained in all reactions, and the products were sufficiently pure to require no further purification. The filtrate was concentrated under vacuum, washed twice with diethyl ether and concentrated again under high vacuum. After drying under reduced pressure, about 95% of the ionic liquid was recovered and compared to the original ionic liquid to verify its purity. The recovered ionic liquid showed no significant difference in efficiency of converting nitrile to acid compared to the original ionic liquid and could be reused 5-6 times without significant reduction in activity.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 28, p. 3802 - 3804
[2] Roczniki Chemii, 1955, vol. 29, p. 1019,1025
[3] Chem.Abstr., 1956, p. 12045

2-Chloro-4-pyridinecarboxylic acid Preparation Products And Raw materials

Raw materials

Isonicotinic acid Hydrogen peroxide Phosphorus oxitrichloride Ethyl acetate Acetic acid

Preparation Products

4-Amino-2-chloropyridine 2-PIPERAZIN-1-YLISONICOTINIC ACID (2-methoxypyridin-4-yl)methanol 4-[4-(Aminomethyl)pyridin-2-yl]piperazine, N1-BOC protected 2-METHOXYPYRIDINE-4-CARBOXALDEHYDE 2-MORPHOLIN-4-YL-ISONICOTINIC ACID 2-MORPHOLINOISONICOTINALDEHYDE 2-[4-(tert-Butoxycarbonyl)piperazin-1-yl]isonicotinic acid tert-Butyl 4-(4-cyanopyrid-2-yl)piperazine-1-carboxylate METHYL 2-METHOXYISONICOTINATE 97%METHYL 2-METHOXYPYRIDINE-4-CARBOXYLATE (2-MORPHOLINOPYRID-4-YL)METHANOL METHYL 2-CHLOROISONICOTINATE
More
Less

2-Chloro-4-pyridinecarboxylic acid Suppliers

Americas 1 Belgium 1 Canada 2 China 390 Europe 3 France 3 Germany 6 India 39 Japan 5 Poland 2 South Korea 1 Switzerland 3 The Netherlands 1 Ukraine 3 United Kingdom 21 United States 60 Global 541
Hengshui Rayson Chemical Technology Co. , Ltd.
Tel
0318-8888981 13785822979
Email
1532555757@qq.com
Country
China
ProdList
27
Advantage
58
Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-82371986 15269101859
Fax
0531-82375893
Email
3276840968@qq.com
Country
China
ProdList
1604
Advantage
58
Wuhan haorong Biotechnology Co., Ltd
Tel
13217229939
Email
773651767@qq.com
Country
China
ProdList
4535
Advantage
58
Shijiazhuang C-element Biotech Co.,Ltd
Tel
18033710157
Email
Lisa@C-elementBiotech.com
Country
China
ProdList
134
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94644
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Liaoning Tianhua Chemical Co., Ltd.
Tel
0418-6530555 2855550
Fax
+86-418-6502885
Country
China
ProdList
338
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6945
Advantage
52
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Fama Shijiazhuang Fine Chemical Co., Ltd.
Tel
0311-88800819 13932107110
Fax
86-0311-85111404
Email
sales@jztchem.com
Country
China
ProdList
14
Advantage
62
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Shijiazhuang Dowell Chemical Co., Ltd
Tel
0311-89805679 17692413312
Fax
0311-85262695
Email
sell@dowechem.com
Country
China
ProdList
61
Advantage
62
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2744
Advantage
58
Amber MolTech LLC
Tel
086-010-62176588
Fax
086-010-62117849
Email
amber@jyamber.com
Country
China
ProdList
10151
Advantage
56
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Shanghai ZaiQi Bio-Tech Co., Ltd.
Tel
021-54824098, 021-37212705 021-37212706, 13391256916
Fax
021-54824069
Email
sales@chemzq.com
Country
China
ProdList
570
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Shenyang Yuancheng Pharmaceutical Technology Co., Ltd.
Tel
024-31298370 15040047923
Fax
024-62665110
Email
yuanchengchem@163.com
Country
China
ProdList
252
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Bsisun HK Imoprt And Export Company Limited
Tel
+86-18068513926
Fax
0086-519-85153711
Country
China
ProdList
1277
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
More
Less

View Lastest Price from 2-Chloro-4-pyridinecarboxylic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-4-pyridinecarboxylic acid 6313-54-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Chloro-4-pyridinecarboxylic acid 6313-54-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-17
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-4-pyridinecarboxylic acid 6313-54-8
Price
US $34.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-03

6313-54-8, 2-Chloro-4-pyridinecarboxylic acidRelated Search:

N,N-Dimethylpropionamide 2,2-Dimethylbutyryl chloride 2-Phenylbutyric acid 2-Chloro-6-methylpyridine-4-carboxylic acid 2,6-CHLORO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER 5-bromo-2-chloro-4-pyridinecarboxylic acid 2-Chloro-3-pyridinecarboxylic acid methyl ester, 2-Chloro-nicotinic acid methyl ester,2-CHLORO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER 4-CHLORO-2-PYRIDINECARBOXYLIC ACID 2,5-Dichloroisonicotinic acid 4-CHLORO-3-PYRIDINECARBOXYLIC ACID 2-CHLORO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER 2-CHLORO-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE tert-Butyl 2,6-dichloroisonicotinate 3-AMINO-2-CHLORO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER 6-Chloro-3-pyridinecarboxylic acid ethyl ester 2-CHLORO-3-PYRIDINECARBOXYLIC ACID / 2-CHLORONICOTINIC ACID,2-CHLORO-3-PYRIDINECARBOXYLIC ACID 6-CHLORO-2-PYRIDINECARBOXYLIC ACID / 6-CHLOROPICOLINIC ACID,6-CHLORO-2-PYRIDINECARBOXYLIC ACID,2-CHLORO-6-PYRIDINECARBOXYLIC ACID 6-Chloro-2-pyridinecarboxylic acid methyl ester

  • 2-Chloroisonicotinic
  • 2-CHLORO-4-PYRIDINYL CARBOXYLIC ACID
  • 2-CHLORO-4-PYRIDINECARBOXYLIC ACID
  • 2-CHLOROISONICOTINIC ACID
  • 2-CHLOROPYRIDINE-4-CARBOXYLIC ACID
  • 2-CHLOROPYRIDINE-4-CARBOXYLICACID(2-CHLOROISO-NICOTINICACID)
  • 2-CHLORO-4-PYRIDINECARBOXYLIC ACID / 2-CHLOROISONICOTINIC ACID
  • 2-Chloroisonicotinic acid ,97%
  • 4-Pyridinecarboxylic acid, 2-chloro-
  • 2-Chloro-4-pyridinec
  • RARECHEM AL BO 0840
  • TIMTEC-BB SBB004003
  • BUTTPARK 43\57-03
  • 2-Chloro-4-carboxy pyridine
  • NSC 40139
  • 2-Chloropyridine-4-carboxylic acid, 4-Carboxy-2-chloropyridine
  • ChloroisonicotinicAcid
  • 2- chlorineisonicotinic acid
  • Chlorine isonicotinic acid 2 -
  • 2-chloro-4-Pyridinecarboxylic aci
  • oropyridine-4-carboxyL
  • 2-Chloro-4-pyridinecarboxylic acid ISO 9001：2015 REACH
  • 2-CHLOROPYRIDINE-4-CARBOXYLICACID(2-CHLOROISO-
  • 2-Chloropyridine-4-carboxylic acid, 98%
  • 2-Chloropyridin-4-carboxylic acid
  • 6313-54-8
  • 6316-54-8
  • Building Blocks
  • Chloropyridines
  • Halopyridines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • pharmacetical
  • Acids and Derivatives
  • Heterocycles
  • blocks
  • Carboxes
  • Pyridines
  • Pyridine
  • pyridine derivative
  • pyridine series
  • Carboxylic Acids
  • Organic acids
  • Chloropyridines
  • Halopyridines
  • Carboxylic Acids
  • Picolinic acid series
  • bc0001