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2-Chloro-4-pyridinecarboxylic acid

Product Name
2-Chloro-4-pyridinecarboxylic acid
CAS No.
6313-54-8
Chemical Name
2-Chloro-4-pyridinecarboxylic acid
Synonyms
2-CHLOROISONICOTINIC ACID;2-CHLOROPYRIDINE-4-CARBOXYLIC ACID;NSC 40139;BUTTPARK 43\57-03;RARECHEM AL BO 0840;TIMTEC-BB SBB004003;2-Chloroisonicotinic;2-Chloro-4-pyridinec;ChloroisonicotinicAcid;oropyridine-4-carboxyL
CBNumber
CB4375001
Molecular Formula
C6H4ClNO2
Formula Weight
157.55
MOL File
6313-54-8.mol
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2-Chloro-4-pyridinecarboxylic acid Property

Melting point:
246 °C (dec.)(lit.)
Boiling point:
417.7±25.0 °C(Predicted)
Density 
1.470±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
pka
3.00±0.10(Predicted)
form 
Crystalline Powder
color 
White to beige
BRN 
115861
InChI
InChI=1S/C6H4ClNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10)
InChIKey
QXCOHSRHFCHCHN-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(C(O)=O)=C1
CAS DataBase Reference
6313-54-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-36/37/39
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
543918
Product name
2-Chloropyridine-4-carboxylic acid
Purity
97%
Packaging
5g
Price
$28.1
Updated
2025/07/31
Sigma-Aldrich
Product number
543918
Product name
2-Chloropyridine-4-carboxylic acid
Purity
97%
Packaging
25g
Price
$101
Updated
2023/06/20
TCI Chemical
Product number
C1368
Product name
2-Chloroisonicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$39
Updated
2025/07/31
TCI Chemical
Product number
C1368
Product name
2-Chloroisonicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$118
Updated
2025/07/31
TRC
Product number
C367375
Product name
2-Chloroisonicotinic Acid
Packaging
1g
Price
$45
Updated
2021/12/16
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2-Chloro-4-pyridinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white crystall powder

Uses

Used in monocomposite films.

Synthesis

33252-30-1

6313-54-8

General procedure for the synthesis of 2-chloroisonicotinic acid from 2-chloro-4-cyanopyridine: 2-chloro-4-cyanopyridine (2 mmol) was dissolved in 5 ml of [bmim]HSO4, and the reaction mixture was heated for 1-3 hours at 60-65 °C. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was poured into water containing crushed ice and the product precipitated as a precipitate. The precipitate was collected by filtration and dried. High yields (>90%) of 2-chloroisonicotinic acid were obtained in all reactions, and the products were sufficiently pure to require no further purification. The filtrate was concentrated under vacuum, washed twice with diethyl ether and concentrated again under high vacuum. After drying under reduced pressure, about 95% of the ionic liquid was recovered and compared to the original ionic liquid to verify its purity. The recovered ionic liquid showed no significant difference in efficiency of converting nitrile to acid compared to the original ionic liquid and could be reused 5-6 times without significant reduction in activity.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 28, p. 3802 - 3804
[2] Roczniki Chemii, 1955, vol. 29, p. 1019,1025
[3] Chem.Abstr., 1956, p. 12045

2-Chloro-4-pyridinecarboxylic acid Preparation Products And Raw materials

Raw materials

Isonicotinic acid Hydrogen peroxide Phosphorus oxitrichloride Ethyl acetate Acetic acid

Preparation Products

4-Amino-2-chloropyridine 2-PIPERAZIN-1-YLISONICOTINIC ACID (2-methoxypyridin-4-yl)methanol 4-[4-(Aminomethyl)pyridin-2-yl]piperazine, N1-BOC protected 2-METHOXYPYRIDINE-4-CARBOXALDEHYDE 2-MORPHOLIN-4-YL-ISONICOTINIC ACID 2-MORPHOLINOISONICOTINALDEHYDE 2-[4-(tert-Butoxycarbonyl)piperazin-1-yl]isonicotinic acid tert-Butyl 4-(4-cyanopyrid-2-yl)piperazine-1-carboxylate METHYL 2-METHOXYISONICOTINATE 97%METHYL 2-METHOXYPYRIDINE-4-CARBOXYLATE (2-MORPHOLINOPYRID-4-YL)METHANOL METHYL 2-CHLOROISONICOTINATE
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2-Chloro-4-pyridinecarboxylic acid Suppliers

Americas 1 Belgium 1 Canada 2 China 390 Europe 3 France 3 Germany 6 India 39 Japan 5 Poland 2 South Korea 1 Switzerland 3 The Netherlands 1 Ukraine 3 United Kingdom 21 United States 60 Global 541
Novasyn Organics Pvt. Ltd (France)
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Country
France
ProdList
303
Advantage
58
Atrofina De Metals Ltd.
Tel
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Fax
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Email
info@atrofinademetals.com
Country
France
ProdList
46
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58
Interchim S.A.
Tel
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Fax
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Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from 2-Chloro-4-pyridinecarboxylic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-4-pyridinecarboxylic acid 6313-54-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Chloro-4-pyridinecarboxylic acid 6313-54-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-17
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-4-pyridinecarboxylic acid 6313-54-8
Price
US $34.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-03

6313-54-8, 2-Chloro-4-pyridinecarboxylic acidRelated Search:

N,N-Dimethylpropionamide 2,2-Dimethylbutyryl chloride 2-Phenylbutyric acid 2-Chloro-6-methylpyridine-4-carboxylic acid 2,6-CHLORO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER 5-bromo-2-chloro-4-pyridinecarboxylic acid 2-Chloro-3-pyridinecarboxylic acid methyl ester, 2-Chloro-nicotinic acid methyl ester,2-CHLORO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER 4-CHLORO-2-PYRIDINECARBOXYLIC ACID 2,5-Dichloroisonicotinic acid 4-CHLORO-3-PYRIDINECARBOXYLIC ACID 2-CHLORO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER 2-CHLORO-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE tert-Butyl 2,6-dichloroisonicotinate 3-AMINO-2-CHLORO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER 6-Chloro-3-pyridinecarboxylic acid ethyl ester 2-CHLORO-3-PYRIDINECARBOXYLIC ACID / 2-CHLORONICOTINIC ACID,2-CHLORO-3-PYRIDINECARBOXYLIC ACID 6-CHLORO-2-PYRIDINECARBOXYLIC ACID / 6-CHLOROPICOLINIC ACID,6-CHLORO-2-PYRIDINECARBOXYLIC ACID,2-CHLORO-6-PYRIDINECARBOXYLIC ACID 6-Chloro-2-pyridinecarboxylic acid methyl ester

  • 2-Chloroisonicotinic
  • 2-CHLORO-4-PYRIDINYL CARBOXYLIC ACID
  • 2-CHLORO-4-PYRIDINECARBOXYLIC ACID
  • 2-CHLOROISONICOTINIC ACID
  • 2-CHLOROPYRIDINE-4-CARBOXYLIC ACID
  • 2-CHLOROPYRIDINE-4-CARBOXYLICACID(2-CHLOROISO-NICOTINICACID)
  • 2-CHLORO-4-PYRIDINECARBOXYLIC ACID / 2-CHLOROISONICOTINIC ACID
  • 2-Chloroisonicotinic acid ,97%
  • 4-Pyridinecarboxylic acid, 2-chloro-
  • 2-Chloro-4-pyridinec
  • RARECHEM AL BO 0840
  • TIMTEC-BB SBB004003
  • BUTTPARK 43\57-03
  • 2-Chloro-4-carboxy pyridine
  • NSC 40139
  • 2-Chloropyridine-4-carboxylic acid, 4-Carboxy-2-chloropyridine
  • ChloroisonicotinicAcid
  • 2- chlorineisonicotinic acid
  • Chlorine isonicotinic acid 2 -
  • 2-chloro-4-Pyridinecarboxylic aci
  • oropyridine-4-carboxyL
  • 2-Chloro-4-pyridinecarboxylic acid ISO 9001：2015 REACH
  • 2-CHLOROPYRIDINE-4-CARBOXYLICACID(2-CHLOROISO-
  • 2-Chloropyridine-4-carboxylic acid, 98%
  • 2-Chloropyridin-4-carboxylic acid
  • 6313-54-8
  • 6316-54-8
  • Building Blocks
  • Chloropyridines
  • Halopyridines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • pharmacetical
  • Acids and Derivatives
  • Heterocycles
  • blocks
  • Carboxes
  • Pyridines
  • Pyridine
  • pyridine derivative
  • pyridine series
  • Carboxylic Acids
  • Organic acids
  • Chloropyridines
  • Halopyridines
  • Carboxylic Acids
  • Picolinic acid series
  • bc0001