ChemicalBook > CAS DataBase List > SR-717

SR-717

Product Name: SR-717
CAS No.: 2375421-09-1
Chemical Name: SR-717
Synonyms: SR171;SR-717;SR-717 lithium;SR171&SR-717 lithium;SR 717 (lithium salt);SR-717, 10 mM in DMSO;4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoate;Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate;immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes
CBNumber: CB47247714
Molecular Formula: C15H10F2LiN5O3
Formula Weight: 353.21
MOL File: 2375421-09-1.mol

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SR-717 Property

storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
color: Off-white
Water Solubility: Water: < 0.1 mg/mL (insoluble)
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
InChI: InChI=1S/C15H9F2N5O3.Li.H/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;;/h1-7H,(H,19,23)(H,24,25);;
InChIKey: FTILLHFNTUUQIF-UHFFFAOYSA-N
SMILES: N(C1C=C(F)C(F)=CC=1C(=O)O)C(C1N=NC(N2C=NC=C2)=CC=1)=O.[LiH]

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 50mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

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SR-717 Chemical Properties,Usage,Production

Description

SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 μM).? It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.

Uses

SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1].

in vivo

SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Sting^gt/gt mice^[1].
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8⁺ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming^[1].

Animal Model:	WT or Sting^gt/gt mice^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneally; once-per-day for 1 week
Result:	Maximally inhibited tumor growth.

References

[1] EMILY N. CHIN. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic[J]. Science, 2020, 369 6506. DOI:10.1126/science.abb4255

SR-717 Preparation Products And Raw materials

Raw materials

Preparation Products

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2375421-09-1, SR-717Related Search:

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SR-717

SR171

SR-717 lithium

SR 717 (lithium salt)

immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes

Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate

SR171&SR-717 lithium

SR-717, 10 mM in DMSO

4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoate

2375421-09-1

C15H8F2LiN5O3