SR-717

Product Name: SR-717
CAS No.: 2375421-09-1
Chemical Name: SR-717
Synonyms: SR171;SR-717;SR-717 lithium;SR171&SR-717 lithium;SR 717 (lithium salt);Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate;immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes
CBNumber: CB47247714
Molecular Formula: C15H10F2LiN5O3
Formula Weight: 353.21
MOL File: 2375421-09-1.mol

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SR-717 Property

storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
color: Off-white
Water Solubility: Water: < 0.1 mg/mL (insoluble)
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 50mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0135108
Product name: SR-717
Purity: 99.75%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

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SR-717 Chemical Properties,Usage,Production

Description

SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 μM).? It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.

References

Chin et al. (2020), Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic; Science 369 993

SR-717 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-717 Suppliers

China 44 United States 6 USA 1 Global 51

2375421-09-1, SR-717Related Search:

2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide 4-Quinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- NA SRT3025 SR9009 SR8278 SR19881 SR-9243 SRPK inhibitor SR 1078 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide SRI 31215 SR 0987 SR27897 SR17018 N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine SR-4835 SR18662

SR-717

SR171

SR-717 lithium

SR 717 (lithium salt)

immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes

Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate

SR171&SR-717 lithium

2375421-09-1