ChemicalBook > CAS DataBase List > 3-Amino-6-chloro-2-picoline

3-Amino-6-chloro-2-picoline

Product Name
3-Amino-6-chloro-2-picoline
CAS No.
164666-68-6
Chemical Name
3-Amino-6-chloro-2-picoline
Synonyms
6-chloro-2-methylpyridin-3-amine;3-AMINO-6-CHLORO-2-METHYLPYRIDINE;2-CHLORO-4-METHYLPYRIDIN-3-AMINE;TIMTEC-BB SBB010194;ASINEX-REAG BAS 13794917;3-AMINO-2-CHLORO-4-PICOLINE;5-AMINO-2-CHLORO-6-PICOLINE;3-AMINO-6-CHLORO-2-PICOLINE;2-CHLORO-5-AMINO-6-PICOLINE;3-Amino-6-chloro-2-picoline ,97%
CBNumber
CB5213991
Molecular Formula
C6H7ClN2
Formula Weight
142.59
MOL File
164666-68-6.mol
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3-Amino-6-chloro-2-picoline Property

Melting point:
93-94℃
Boiling point:
232.49°C (rough estimate)
Density 
1.2124 (rough estimate)
refractive index 
1.4877 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka
1.79±0.10(Predicted)
form 
Solid
color 
Pale yellow
CAS DataBase Reference
164666-68-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T,Xn
Risk Statements 
22-37/38-41-20/21/22
Safety Statements 
26-39-36/37-24/25
RIDADR 
2811
HazardClass 
IRRITANT, TOXIC
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C369830
Product name
6-Chloro-2-methylpyridin-3-amine
Packaging
10g
Price
$470
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021133
Product name
3-AMINO-6-CHLORO-2-PICOLINE
Purity
95.00%
Packaging
1G
Price
$608.69
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA55486
Product name
3-Amino-6-chloro-2-methylpyridine
Packaging
50g
Price
$640
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021133
Product name
3-AMINO-6-CHLORO-2-PICOLINE
Purity
95.00%
Packaging
5G
Price
$865.1
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-5-20
Product name
6-Chloro-2-methylpyridin-3-amine
Packaging
5G
Price
$95
Updated
2021/12/16
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3-Amino-6-chloro-2-picoline Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

6-Chloro-2-methylpyridin-3-amine has been used as a reactant in the preparation of Pyrido[3,2-e][1,4]diazepine derivatives with anti-HIV-1-activity.

Synthesis

22280-60-0

164666-68-6

Step 1: Synthesis of 6-chloro-2-methylpyridin-3-amine (44). 2-Chloro-5-nitro-6-methylpyridine (43, 5 g, 29 mmol) was dissolved in ethanol (20 mL) and concentrated hydrochloric acid was added slowly with stirring. Powdered hydrochloric acid (16.2 g, 289 mmol) and additional concentrated hydrochloric acid (20 mL) were added in batches over 30 minutes at room temperature. After addition, stirring was continued for 30 minutes at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the residue and neutralized with sodium bicarbonate to neutral. Subsequently, ethyl acetate was added for extraction and the two-phase mixture was filtered through diatomaceous earth and washed with ethyl acetate. The organic phase was separated, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate and concentrated to give the target product 44 (4.1 g, 99% yield) as a yellow solid.

References

[1] Patent: WO2017/4608, 2017, A1. Location in patent: Paragraph 0164
[2] Patent: WO2017/4609, 2017, A1. Location in patent: Paragraph 0235
[3] Archiv der Pharmazie, 1995, vol. 328, # 3, p. 247 - 255
[4] Chemistry of Heterocyclic Compounds, 1996, vol. 32, # 10, p. 1173 - 1177
[5] Journal of the American Chemical Society, 1947, vol. 69, p. 63,66

3-Amino-6-chloro-2-picoline Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate 2-Amino-6-methyl-5-nitropyridine Potassium hydroxide 2-Amino-6-methylpyridine tert-Butanol Phosphorus oxitrichloride Sodium borohydride Sodium nitrite Phosphorus pentachloride Nitric acid Methanol Iron Sulfuric acid

Preparation Products

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View Lastest Price from 3-Amino-6-chloro-2-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-Amino-6-chloro-2-picoline 164666-68-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Henan Aochuang Chemical Co.,Ltd.
Product
3-Amino-6-chloro-2-picoline 164666-68-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-22
Henan Fengda Chemical Co., Ltd
Product
3-Amino-6-chloro-2-picoline 164666-68-6
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

164666-68-6, 3-Amino-6-chloro-2-picolineRelated Search:

2-(Chloromethyl)pyridine 2-Chloro-5-methylpyridine 4-Aminopyridine 6-Aminocaproic acid 6-Chloro-2-picoline ALTRENOGEST 4-Dimethylaminopyridine 2-Amino-6-methylpyridine 2-Picoline 2-Amino-6-chloropyridine 3-Aminopyridine 2-Chloro-5-chloromethylpyridine 2,6-Lutidine 5-Amino-2-methylpyridine Glycine Tris(hydroxymethyl)aminomethane Difluorochloromethane 6-Chloro-2-methyl-3-nitropyridine

  • ASINEX-REAG BAS 13794917
  • 2-methyl-3-amino-6-chloropyridine
  • 5-AMINO-2-CHLORO-6-METHYLPYRIDINE
  • TIMTEC-BB SBB010194
  • 3-AMINO-2-CHLORO-4-PICOLINE
  • 3-AMINO-2-CHLORO-4-METHYLPYRIDINE
  • 3-AMINO-6-CHLORO-2-METHYLPYRIDINE
  • 3-AMINO-6-CHLORO-2-PICOLINE
  • 5-AMINO-2-CHLORO-6-PICOLINE
  • 6-CHLORO-2-METHYL-PYRIDIN-3-YLAMINE
  • 2-CHLORO-4-METHYLPYRIDIN-3-AMINE
  • 2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE
  • 2-CHLORO-5-AMINO-6-PICOLINE
  • 2-CHLORO-6-METHYL-5-AMINOPYRIDINE
  • 5-Amino-2-chloro-6-methylpyridine (3-Amino-6-chloro-2-methylpyridine)
  • 3-Pyridinamine,6-chloro-2-methyl-(9CI)
  • 6-chloro-2-methylpyridin-3-amine
  • 3-Amino-6-chloro-2-picoline ,97%
  • 2-CHLORO-5-AMINO-6-METHYLPYRIDINE
  • 6-Chloro-2-methyl-3-pyridinamine
  • 6-chloro-2-Methyl-[3]pyridylaMine
  • 3-Pyridinamine, 6-chloro-2-methyl-
  • 3-Amino-6-chloro-2-methylpyridine,95%
  • 3-Amino-6-chloro-2-picoline ISO 9001：2015 REACH
  • 2 - methyl 5 - amino 6 - chloro pyridine
  • 164666-68-6
  • 1092349-78-7
  • Chloropyridines
  • Halopyridines
  • Boronic Acid
  • Amino-pyridine series
  • Pyridine series
  • Pyridines
  • PYRIDINE
  • HALIDE