ChemicalBook > CAS DataBase List > GSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII

Product Name
GSK-3β Inhibitor XVIII
CAS No.
1139875-74-3
Chemical Name
GSK-3β Inhibitor XVIII
Synonyms
GSK3β-IN-1a;GSK3β-IN-1a;GSK-3β inhibitor 8;GSK3β Inhibitor XVIII;GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-
CBNumber
CB52602508
Molecular Formula
C20H20ClN5OS
Formula Weight
413.92
MOL File
1139875-74-3.mol
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GSK-3β Inhibitor XVIII Property

Boiling point:
632.3±65.0 °C(Predicted)
Density 
1.358±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMSO: soluble
pka
6?+-.0.10(Predicted)
form 
White solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
361562
Product name
GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
Packaging
5mg
Price
$238
Updated
2023/01/07
Cayman Chemical
Product number
21198
Product name
GSK3β Inhibitor XVIII
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21198
Product name
GSK3β Inhibitor XVIII
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
21198
Product name
GSK3β Inhibitor XVIII
Packaging
10mg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
21198
Product name
GSK3β Inhibitor XVIII
Packaging
25mg
Price
$745
Updated
2024/03/01
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GSK-3β Inhibitor XVIII Chemical Properties,Usage,Production

Description

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

GSK-3β Inhibitor XVIII Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-3β Inhibitor XVIII Suppliers

China 14 United States 3 Global 17
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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9806
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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11217
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Jinan Jiuli Biotechnology Co. , Ltd.
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15865264761
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486064515@qq.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Nanjing Tengyi Biotechnology Co., Ltd
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025-58851786 17714337195
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sales@tybiochem.com
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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025-85563444
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cindy.huang@synzest.com
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Nantong Hanfang Biotechnology Co. , Ltd.
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18616537568
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hanfangpharma@126.com
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China
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30961
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4008-099-669
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23419001name@qq.com
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CHINA
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70071
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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Morning Student Science and Technology (Guangzhou) Co., Ltd.
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chenxue_gz@163.com
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CHINA
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Absin Bioscience Inc.
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chenjw@absin.cn
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Boao Pike
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CHINA
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Shanghai Hao Biological Technology Co., Ltd.
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shxiyuanbio@163.com
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1139875-74-3, GSK-3β Inhibitor XVIIIRelated Search:

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE NSC 23766 TETRAHYDROCHLORIDE NSC697923 MIF Antagonist, ISO-1 Pictilisib JNJ-10198409 Chk2 Inhibitor Trolox C2 CERAMIDE Motesanib PD 173074 Compound 28 Glycogen Phosphorylase Inhibitor MMP-9 INHIBITOR I Compound 23 ERK Inhibitor 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

  • GSK-3β Inhibitor XVIII
  • GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
  • GSK3β-IN-1a
  • GSK3β Inhibitor XVIII
  • Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-
  • GSK3β-IN-1a
  • 2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone
  • GSK-3β inhibitor 8
  • 1139875-74-3