GSK-3β Inhibitor XVIII

Product Name: GSK-3β Inhibitor XVIII
CAS No.: 1139875-74-3
Chemical Name: GSK-3β Inhibitor XVIII
Synonyms: GSK3β-IN-1a;GSK3β-IN-1a;GSK-3β inhibitor 8;GSK3β Inhibitor XVIII;GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-
CBNumber: CB52602508
Molecular Formula: C20H20ClN5OS
Formula Weight: 413.92
MOL File: 1139875-74-3.mol

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GSK-3β Inhibitor XVIII Property

Boiling point:: 632.3±65.0 °C(Predicted)
Density: 1.358±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: DMSO: soluble
pka: 6?+-.0.10(Predicted)
form: White solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 361562
Product name: GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
Packaging: 5mg
Price: $238
Updated: 2023/01/07

Cayman Chemical

Product number: 21198
Product name: GSK3β Inhibitor XVIII
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 21198
Product name: GSK3β Inhibitor XVIII
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 21198
Product name: GSK3β Inhibitor XVIII
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 21198
Product name: GSK3β Inhibitor XVIII
Packaging: 25mg
Price: $745
Updated: 2024/03/01

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GSK-3β Inhibitor XVIII Chemical Properties,Usage,Production

Description

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC₅₀ = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC₅₀ = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC₅₀ = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

GSK-3β Inhibitor XVIII Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-3β Inhibitor XVIII Suppliers

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1139875-74-3, GSK-3β Inhibitor XVIIIRelated Search:

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE NSC 23766 TETRAHYDROCHLORIDE NSC697923 MIF Antagonist, ISO-1 Pictilisib JNJ-10198409 Chk2 Inhibitor Trolox C2 CERAMIDE Motesanib PD 173074 Compound 28 Glycogen Phosphorylase Inhibitor MMP-9 INHIBITOR I Compound 23 ERK Inhibitor 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

GSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem

GSK3β-IN-1a

GSK3β Inhibitor XVIII

Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-

GSK3β-IN-1a

2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone

GSK-3β inhibitor 8

1139875-74-3