ChemicalBook > CAS DataBase List > SCRIPTAID
SCRIPTAID
- Product Name
- SCRIPTAID
- CAS No.
- 287383-59-9
- Chemical Name
- SCRIPTAID
- Synonyms
- CS-1136;GCK 1026;Scriptide;Scriptaid (GCK1026);Scriptaid, Scriptide;GCK 1026; SCRIPTIDE; GCK1026; GCK-1026;6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-;6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanaMide;Scriptide N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
- CBNumber
- CB5504770
- Molecular Formula
- C18H18N2O4
- Formula Weight
- 326.35
- MOL File
- 287383-59-9.mol
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SCRIPTAID Property
- Melting point:
- 160-161 °C
- Density
- 1.338±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 4 mg/ml).
- pka
- 9.46±0.20(Predicted)
- form
- Yellow solid.
- color
- White
- Sensitive
- Light Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S7817
- Product name
- Scriptaid
- Purity
- ≥95%, solid
- Packaging
- 1MG
- Price
- $145
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- S7817
- Product name
- Scriptaid
- Purity
- ≥95%, solid
- Packaging
- 5MG
- Price
- $493
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 565730
- Product name
- Scriptaid - CAS 287383-59-9 - Calbiochem
- Purity
- A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.
- Packaging
- 5MG
- Price
- $194
- Updated
- 2022/05/15
Alfa Aesar
- Product number
- J67379
- Product name
- Scriptaid, 97%
- Packaging
- 1mg
- Price
- $101
- Updated
- 2021/12/16
Cayman Chemical
- Product number
- 10572
- Product name
- Scriptaid
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
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SCRIPTAID Chemical Properties,Usage,Production
Description
Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-
Uses
Scriptaid has been used in post activation of oocytes and embryo culture.
Uses
Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.
Definition
ChEBI: 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide is a member of isoquinolines.
General Description
Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.
Biological Activity
Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.
Biochem/physiol Actions
Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.
References
1) Su?et al.?(2000),?A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res.,?60?3137 2) Huber?et al.?(2011),?Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem.,?286?22211 3) Lee?et al.?(2008),?Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol.,?33?767 4) Rissi?et al.?(2019),?Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction,?157?123 5) Huang?et al.?(2020),?Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol.,?128?276
SCRIPTAID Preparation Products And Raw materials
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View Lastest Price from SCRIPTAID manufacturers
Hebei Mojin Biotechnology Co., Ltd
- Product
- SCRIPTAID 287383-59-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-28
Career Henan Chemical Co
- Product
- 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide 287383-59-9
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09
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