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SCRIPTAID

Product Name
SCRIPTAID
CAS No.
287383-59-9
Chemical Name
SCRIPTAID
Synonyms
CS-1136;GCK 1026;Scriptide;Scriptaid (GCK1026);Scriptaid, Scriptide;GCK 1026; SCRIPTIDE; GCK1026; GCK-1026;6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-;6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanaMide;Scriptide N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
CBNumber
CB5504770
Molecular Formula
C18H18N2O4
Formula Weight
326.35
MOL File
287383-59-9.mol
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SCRIPTAID Property

Melting point:
160-161 °C
Density 
1.338±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 4 mg/ml).
pka
9.46±0.20(Predicted)
form 
Yellow solid.
color 
White
Sensitive 
Light Sensitive
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7817
Product name
Scriptaid
Purity
≥95%, solid
Packaging
1MG
Price
$145
Updated
2023/06/20
Sigma-Aldrich
Product number
S7817
Product name
Scriptaid
Purity
≥95%, solid
Packaging
5MG
Price
$493
Updated
2023/06/20
Sigma-Aldrich
Product number
565730
Product name
Scriptaid - CAS 287383-59-9 - Calbiochem
Purity
A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.
Packaging
5MG
Price
$194
Updated
2022/05/15
Alfa Aesar
Product number
J67379
Product name
Scriptaid, 97%
Packaging
1mg
Price
$101
Updated
2021/12/16
Cayman Chemical
Product number
10572
Product name
Scriptaid
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
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SCRIPTAID Chemical Properties,Usage,Production

Description

Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo. Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.

Uses

Scriptaid has been used in post activation of oocytes and embryo culture.

Uses

Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.

Definition

ChEBI: 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide is a member of isoquinolines.

General Description

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Biological Activity

Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

Biochem/physiol Actions

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

References

1) Su?et al.?(2000),?A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res.,?60?3137 2) Huber?et al.?(2011),?Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem.,?286?22211 3) Lee?et al.?(2008),?Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol.,?33?767 4) Rissi?et al.?(2019),?Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction,?157?123 5) Huang?et al.?(2020),?Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol.,?128?276

SCRIPTAID Preparation Products And Raw materials

Raw materials

Preparation Products

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SCRIPTAID Suppliers

Canada 1 China 95 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 1 United States 22 Global 123
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
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View Lastest Price from SCRIPTAID manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
SCRIPTAID 287383-59-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-28
Career Henan Chemical Co
Product
6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide 287383-59-9
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

287383-59-9, SCRIPTAIDRelated Search:

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  • 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
  • GCK 1026; SCRIPTIDE; GCK1026; GCK-1026
  • CS-1136
  • GCK 1026
  • 1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-
  • Scriptide
  • 6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanaMide
  • Scriptaid, Scriptide
  • Scriptide N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
  • Scriptaid (GCK1026)
  • 287383-59-9
  • Inhibitor
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals