Chloroacetyl chloride

Product Name: Chloroacetyl chloride
CAS No.: 79-04-9
Chemical Name: Chloroacetyl chloride
Synonyms: 2-CHLOROACETYL CHLORIDE;chloroacetyl;Chloroacetic ahloride;CHLORACETYL CHLORIDE;Chloroacetic chloride;alpha-Chloroacetyl chloride;Chloroac;CH2ClCOCl;oroacetyL;chloracetyl
CBNumber: CB6202877
Molecular Formula: C2H2Cl2O
Formula Weight: 112.94
MOL File: 79-04-9.mol

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Chloroacetyl chloride Property

Melting point:: −22 °C(lit.)
Boiling point:: 105-106 °C(lit.)
Density: 1.419 g/mL at 20 °C
vapor density: 3.9 (vs air)
vapor pressure: 60 mm Hg ( 41.5 °C)
refractive index: n20/D 1.453(lit.)
Flash point:: >100°C
storage temp.: Store at RT.
solubility: Miscible with ethyl ether, acetone, benzene and carbon tetrachloride.
form: Liquid
color: Clear colorless to slightly yellow
Odor: strong pungent odor
Water Solubility: reacts
FreezingPoint: -22.5℃
Sensitive: Moisture Sensitive
Merck: 14,2067
BRN: 605439
Exposure limits: ACGIH: TWA 0.05 ppm; STEL 0.15 ppm (Skin)
NIOSH: IDLH 1.3 ppm; TWA 0.05 ppm(0.2 mg/m3)
Stability:: Stable. Incompatible with strong bases, alcohols, strong oxidizing agents. May react violently on exposure to water or moisture.
CAS DataBase Reference: 79-04-9(CAS DataBase Reference)
NIST Chemistry Reference: Acetyl chloride, chloro-(79-04-9)
EPA Substance Registry System: Chloroacetyl chloride (79-04-9)

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Safety

Hazard Codes: T,C,N
Risk Statements: 14-23/24/25-35-48/23-50-29
Safety Statements: 9-26-36/37/39-45-61-7/8
RIDADR: UN 1752 6.1/PG 1
OEB: C
OEL: TWA: 0.05 ppm (0.2 mg/m3)
WGK Germany: 3
RTECS: AO6475000
TSCA: Yes
HazardClass: 6.1
PackingGroup: I
HS Code: 29159000
Hazardous Substances Data: 79-04-9(Hazardous Substances Data)
IDLA: 1.3 ppm (6 mg/m3)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H372Causes damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 22880
Product name: Chloroacetyl chloride
Purity: purum, ≥99.0% (GC)
Packaging: 100ML
Price: $39
Updated: 2023/06/20

Sigma-Aldrich

Product number: 22880
Product name: Chloroacetyl chloride
Purity: purum, ≥99.0% (GC)
Packaging: 500ML
Price: $103
Updated: 2023/06/20

Sigma-Aldrich

Product number: 22880
Product name: Chloroacetyl chloride
Purity: purum, ≥99.0% (GC)
Packaging: 1L
Price: $180
Updated: 2023/06/20

Sigma-Aldrich

Product number: 104493
Product name: Chloroacetyl chloride
Purity: 98%
Packaging: 5G
Price: $29.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 104493
Product name: Chloroacetyl chloride
Purity: 98%
Packaging: 100G
Price: $36.4
Updated: 2023/06/20

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Chloroacetyl chloride Chemical Properties,Usage,Production

Description

Chloroacetyl chloride is a colorless to yellowish liquid with a very pungent, extremely irritating, odor.Molecular weight=112.95; Specific gravity (H2O:1) 51.42; Boiling point=105℃; Freezing/Meltingpoint=222℃; Vapor pressure=19 mmHg at 20℃.NFPA 704 M Rating System: Health 3, Flammability 1,Reactivity 1 . Reacts violently with water.

Chemical Properties

Chloroacetyl chloride is a colorless to yellowish liquid with a very pungent, extremely irritating, odor.

Uses

Chloroacetyl chloride is an intermediate in the production of alachlor and butachlor. It is used to prepare phenacyl chloride through Friedel-Crafts acylation of benzene.

Uses

Intermediate in manufacture of chloroacetophenone and various other chemicals

Uses

In the synthesis of organic compounds.

Application

Chloroacetyl chloride can be used for chloroacetylation and chemical modification of poly(glycidyl methacrylate).
Chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes. Chloroacetyl chloride was used in the synthesis of some novel quinoline derivatives having antileishmanial activity.

Preparation

Chloroacetyl chloride is usually manufactured from chloroacetic acid by reaction with phosphorus trichloride, thionyl chloride, sulfuryl chloride, or phosgene. It is also obtained by chlorination of acetyl chloride in the presence of stronger aliphatic acids, preferably chloroacetic acids, or from sodium chloroacetate and the usual chlorinating agents.
Koenig G et al; Chloroacetic Acids. Ullmann's Encyclopedia of Industrial Chemistry 7th ed. (1999-2018). NY, NY: John Wiley & Sons. Online Posting Date: October 15, 2012

Definition

Chloroacetyl chloride is classified as an acyl halide. It is a colorless to light yellow liquid with a strong, pungent odor. This compound is highly toxic when inhaled and can corrode both metal surfaces and tissues.

General Description

A colorless to light yellow liquid with a very pungent odor. Very toxic by inhalation. Corrosive to metals and tissue.

Reactivity Profile

Chloroacetyl chloride reacts rapidly with water. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Hazard

Irritant to eyes, corrosive to skin. Upper respiratory tract irritant.

Health Hazard

Inhalation causes severe irritation of upper respiratory system. External contact causes severe irritation of eyes and skin. Ingestion causes severe irritation of mouth and stomach.

Safety Profile

Poison by ingestion and intravenous routes. Mildly toxic by inhalation. Corrosive. A lachrymator. When heated to decomposition it emits toxic fumes of Cl-.

Potential Exposure

Highly toxic by inhalation. Chloroacetyl chloride is used in the manufacture of acetophenone. It is used in the manufacture of a number of pesticides including: alachlor, allidochlor, butachlor, dimethachlor, formothion, mecarbam, metolachlor, propachlor. It is also used in the manufacture of pharmaceuticals, such as chlordiazepoxide hydrochloride, diazepam, lidocaine, mianserin.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting. Medical observation isrecommended for 24-48 h after breathing overexposure, aspulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consideradministering a corticosteroid spray.

Carcinogenicity

Chloroacetyl chloride was not genotoxic in a number of assays.

storage

Chloroacetyl chloride must carry a“CORROSIVE” label. It falls in Hazard Class 8 andPacking Group I.

Shipping

UN1752 Chloroacetyl chloride, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive material, Inhalation Hazard Zone B.

Incompatibilities

Reacts violently with water, steamforming chloroacetic acid and hydrogen chloride gas. Reacts with alcohols, powdered metals; sodium amide; combustibles; and many organics, causing toxic fumes, fire, and explosion hazard. On contact with air it emits corrosive gas. Decomposes when heated forming phosgene gas. Corrosive to metals.

Waste Disposal

It may be discharged into sodium bicarbonate solution, then flushed to the sewer with water.

Chloroacetyl chloride Preparation Products And Raw materials

Raw materials

Acetyl ketene Sulfur Chloroacetic acid Chlorine Zinc chloride Molybdenum disulfide Chlorosulfonic acid PHOSGENE Sulfur dichloride Benzoyl chloride METHANE

Preparation Products

4-(Acetylamino)phenyl chloroacetate 2-Chloro-N-(2,6-dimethylphenyl)acetamide D-Serine 5-Methylthianaphthene ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE 2-Chloro-N,N-dimethylacetamide Propacetamol 7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate Benzyl 2-chloroacetate 2-AMINO-3-CYANO-4-CHLORO-5-FORMYLTHIOPHENE D-Threonine Lidocaine hydrochloride CHLOROMETHYLACETAMIDE Pretilachlor Demoxepam 2-AMINO-1-MORPHOLIN-4-YL-ETHANONE HCL Diclofenac sodium N-METHYL-N-PHENYL-2-PIPERAZIN-1-YLACETAMIDE FLURAZEPAM Metolachlor Anilofos Azasetron hydrochloride D-Tyrosine Bonnecor tert-Butyl chloroacetate 6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE N-(2-benzoyl-4-nitrophenyl)-2-chloroacetamide Praziquantel Nitrazepam Pirenzepine Morphothion emulsion Lidocaine Estazolam Diazapam CHLOROTRIANISENE 2-Chloroacetophenone Lorazepam 6-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE 2,2',4'-Trichloroacetophenone Propachlor

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Chloroacetyl chloride Suppliers

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View Lastest Price from Chloroacetyl chloride manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Chloroacetyl chloride 79-04-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-26

Yancheng Green Chemicals Co.,Ltd

Product: Chloroacetyl chloride 79-04-9
Price: US $0.00/kg/drum
Min. Order: 250kg/drum
Purity: 99%
Supply Ability: 100000MT
Release date: 2023-02-28

Hebei Weibang Biotechnology Co., Ltd

Product: Chloroacetyl chloride 79-04-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-10-25

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79-04-9

1979-04-9

28954

1979-4-9

28-95-4

79-40-9

74-04-9

250ML/瓶[79-04-9

1979/4/9

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