tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

Physical Form

Product Name: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
CAS No.: 571188-59-5
Chemical Name: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Synonyms: 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;POB02;PALBOCICLIB4;Ribociclib-2;Palbociclib-11
CBNumber: CB62464781
Molecular Formula: C14H22N4O2
Formula Weight: 278.35
MOL File: 571188-59-5.mol

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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Property

Melting point:: 130-132℃
Boiling point:: 454.1±45.0 °C(Predicted)
Density: 1.182
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Very Slightly)
form: Solid
pka: 7.36±0.26(Predicted)
color: Dark Yellow
Sensitive: Air Sensitive
InChI: InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)
InChIKey: RMULRXHUNOVPEI-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1
LogP: 1.6-1.8 at 35℃ and pH7-9

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4669
Product name: tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $66
Updated: 2024/03/01

TCI Chemical

Product number: B4669
Product name: tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $239
Updated: 2024/03/01

Alfa Aesar

Product number: H54315
Product name: 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
Packaging: 1g
Price: $170.65
Updated: 2024/03/01

Alfa Aesar

Product number: H54315
Product name: 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
Packaging: 5g
Price: $673.65
Updated: 2024/03/01

Alfa Aesar

Product number: H54315
Product name: 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
Packaging: 250mg
Price: $57.6
Updated: 2021/12/16

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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Physical Form

Solid

Description

Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.

Uses

4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.

Preparation

4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.

Hazard

Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate manufacturers

Sinoway Industrial co., ltd.

Product: Palbociclib side chain 571188-59-5
Price: US $0.00-0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 0.98
Supply Ability: 20 tons
Release date: 2023-05-23

WUHAN FORTUNA CHEMICAL CO., LTD

Product: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-30

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Palbociclib Impurity 10 571188-59-5
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-08-13

571188-59-5, tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylateRelated Search:

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1-N-BOC-4-BROMOPIPERIDINE Copper(II) chloride dihydrate Iodomethane sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER PD 0332991 HCl 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester LEE011 (succinate) 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- LEE011 (hydrochloride) 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)- Palbociclib tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate

1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

OTAVA-BB 1207229

4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester

1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester

tert-butyl 4-(6-aMinopyri

4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic

PALBOCICLIB4

2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecarboxylate

6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected 98%

1-Butyloxycarbonyl-4-(6-aminopyridin-3-yl)-piperazine

Palbociclib Impurity 68

Palbociclib-018

Palbociclib-11

Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-carboxylate

POB02

OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine

tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-carboxylate

4-(6-AMinopyridin-3-yl)-1-Boc-piperazine

tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate

tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate(For Palbociclib)

Palbociclib's intermediate

4-(6-aMinopyridin-3-yl)p

t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)

Palbociclib Intermediate

Ribociclib-2

<i>tert</i>-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate

Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Carboxylate

4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester

OTAVA-BB 1207229 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

1-(tert-Butoxycarbonyl)-4-(6-aminopyridin-3-yl)piperazine

OTAVA-BB

Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571188-59-5)

4-(6-Amino-3-pyridyl)-1-Boc-piperazine

1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN

tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate &gt

4-(6-aminopyridine-3-yl) piperazine-1-carboxylic tert-butyl ester

)piperazine-1-carboxyL

Ribociclib Related Compound 1

Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-carboxylate

4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl carboxylate

ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

1-Boc-4-(6-amino-3-pyridyl)piperazine

1-tert-Butoxycarbonyl-4-(6-amino-3-pyridyl)piperazine

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

Palbociclib side chain

4- (6-aminopyridine-3-yl) piperazin-1-carboxylic acid tert-butyl ester

tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-carboxylate

571188-59-5

571188-59-9

PD 0332991

Palbociclib

Anticancer

571188-59-5