ChemicalBook > CAS DataBase List > NVP-BSK805

NVP-BSK805

Product Name
NVP-BSK805
CAS No.
1092499-93-8
Chemical Name
NVP-BSK805
Synonyms
BSK805;CS-550;CS-1571;BSK 805;BSK-805;NVP-BSK805;NVP-GSK 805;NVP-BSK805 2HCl;NVP-BSK805 - BSK 805;NVP-BSK805 USP/EP/BP
CBNumber
CB62561486
Molecular Formula
C27H28F2N6O
Formula Weight
490.55
MOL File
1092499-93-8.mol
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NVP-BSK805 Property

Melting point:
137℃
Boiling point:
639.8±55.0 °C(Predicted)
Density 
1.4
storage temp. 
Store at -20°C
solubility 
≥20.95 mg/mL in DMSO; ≥3.45 mg/mL in H2O with gentle warming and ultrasonic; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
9.78±0.10(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5818
Product name
NVPBSK805
Purity
≥98%(HPLC)
Packaging
10
Price
$205
Updated
2021/12/16
Axon Medchem
Product number
Axon2792
Product name
NVP-BSK805-BSK805
Purity
99%
Packaging
5mg
Price
$137.5
Updated
2021/12/16
ApexBio Technology
Product number
A3675
Product name
NVP-BSK805
Packaging
5mg
Price
$179
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD43354
Product name
NVP BSK 805
Packaging
10mg
Price
$185
Updated
2021/12/16
AK Scientific
Product number
2606AH
Product name
NVP-BSK805dihydrochloride
Packaging
2mg
Price
$200
Updated
2021/12/16
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NVP-BSK805 Chemical Properties,Usage,Production

Uses

NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively[1].

in vivo

NVP-BSK805 (BSK 805; 150 mg/kg, p.o.) blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading in a Ba/F3 JAK2V617F cell-driven mouse model[1].
NVP-BSK805 (50, 75, and 100 mg/kg, p.o.) also suppresses rhEpo-mediated polycythemia and splenomegaly in BALB/c mice[1].

target

JAK2

IC 50

JAK2 JH1: 0.48 nM (IC50); FL JAK2 V617F: 0.56 nM (IC50); FL JAK2 wt: 0.58 nM (IC50); TYK2 JH1: 10.76 nM (IC50); JAK3 JH1: 18.68 nM (IC50); JAK1 JH1: 31.63 nM (IC50)

References

[1] Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. DOI:10.1158/1535-7163.MCT-10-0053
[2] Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182. DOI:10.1016/j.bbrc.2017.06.178

NVP-BSK805 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-BSK805 Suppliers

China 94 India 1 United Kingdom 1 United States 20 Global 116
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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ApexBio Technology LLC
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+1-832-696-8203
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+1-832-641-3177
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Target molecule Corp.
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857-239-0968
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857-239-8801
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service1@targetmol.com
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Musechem
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InvivoChem
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708-557-7486
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Cckinase, Inc.
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BOC Sciences
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TargetMol Chemicals Inc.
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Aceschem Inc.
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ApexBio Technology
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Creative Enzymes
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Axon Medchem LLC
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Matrix Scientific
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View Lastest Price from NVP-BSK805 manufacturers

Career Henan Chemical Co
Product
NVP-BSK805 1092499-93-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

1092499-93-8, NVP-BSK805Related Search:

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  • NVP-BSK805 2HCl
  • NVP-BSK805
  • NVP-BSK805 dihydrochloride
  • 8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline
  • 8-(3,5-difluoro-4-(morpholinomethyl)phenyl)-2-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxaline
  • BSK 805
  • BSK805
  • BSK-805
  • 4-(2,6-Difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine
  • NVP-BSK805 - BSK 805
  • CS-1571
  • BSK 805; BSK-805; BSK805; NVP-BSK 805
  • CS-550
  • NVP-GSK 805
  • Quinoxaline, 8-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
  • NVP-BSK805 USP/EP/BP
  • NVP-BSK805(freebase)
  • 8-{3,5-difluoro-4-[(morpholin-4-yl)methyl]phenyl}-2-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]quinoxaline
  • NVP-BSK805 dihydrochloride (BSK805 dihydrochloride
  • 1092499-93-8
  • C27H28F2N6O
  • C27H28F2N6O2HCl
  • Inhibitors
  • JAK
  • STAT
  • Inhibitor