ChemicalBook > CAS DataBase List > 4-Fluorobenzaldehyde

4-Fluorobenzaldehyde

Product Name
4-Fluorobenzaldehyde
CAS No.
459-57-4
Chemical Name
4-Fluorobenzaldehyde
Synonyms
PFBA;P-FLUOROBENZALDEHYDE;PFAD;Benzaldehyde, 4-fluoro-;NSC 68095;JACS-459-57-4;AKOS BBS-00003166;4-Fluorbenzaldehyd;P-FLUORBENZALDEHYDE;p-Fluoro benzaldehy
CBNumber
CB6299747
Molecular Formula
C7H5FO
Formula Weight
124.11
MOL File
459-57-4.mol
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4-Fluorobenzaldehyde Property

Melting point:
-10 °C (lit.)
Boiling point:
181 °C/758 mmHg (lit.)
Density 
1.157 g/mL at 25 °C (lit.)
vapor pressure 
19 hPa (70 °C)
refractive index 
n20/D 1.521(lit.)
Flash point:
134 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform, Methanol
form 
Liquid
color 
Clear colorless to yellow
Specific Gravity
1.157
Water Solubility 
IMMISCIBLE
Sensitive 
Air Sensitive
BRN 
385857
Stability:
Air Sensitive
InChIKey
UOQXIWFBQSVDPP-UHFFFAOYSA-N
CAS DataBase Reference
459-57-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 4-fluoro-(459-57-4)
EPA Substance Registry System
Benzaldehyde, 4-fluoro- (459-57-4)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39-36/37/39-27
RIDADR 
UN 1989 3/PG 3
WGK Germany 
2
F 
9-23
Hazard Note 
Flammable
TSCA 
T
HazardClass 
3.2
PackingGroup 
III
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
128376
Product name
4-Fluorobenzaldehyde
Purity
98%
Packaging
10g
Price
$29.4
Updated
2024/03/01
Sigma-Aldrich
Product number
128376
Product name
4-Fluorobenzaldehyde
Purity
98%
Packaging
50g
Price
$76.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18537
Product name
4-Fluorobenzaldehyde
Purity
for synthesis
Packaging
25mL
Price
$51.5
Updated
2023/01/07
TCI Chemical
Product number
F0191
Product name
4-Fluorobenzaldehyde
Purity
>98.0%(GC)
Packaging
25mL
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
F0191
Product name
4-Fluorobenzaldehyde
Purity
>98.0%(GC)
Packaging
250mL
Price
$183
Updated
2024/03/01
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4-Fluorobenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

Usually used in the preparation of pyrazolopyridine UR-13756.

Uses

4-Fluorobenzaldehyde is used in the preparation of pyrazolopyridine derivative, which finds application as mitogen-activated protein kinase (MAPK) inhibitor. It also serves as a synthetic intermediate in the preparation of pharmaceutical compounds.

Uses

4-Fluorobenzaldehyde is a fluorinated benzaldehyde with inhibitory activity of mushroom tyrosinase. 4-Fluorobenzaldehyde is commonly used as a synthetic intermediate in the preparation of pharmaceutic al compounds.

Synthesis

4-Fluorobenzaldehyde is produced by a commercially feasible process. The process comprises heating a mixture of fluorobenzene and a strong Lewis acid with dissolved hydrogen halide in an atmosphere of carbon monoxide at about 45 to about 100° C. and at a total pressure of about 150 psig up to the maximum pressure rating of the reactor. Formed is a reaction mass containing a Lewis acid complex of 4-fluorobenzaldehyde and at least a halobis(fluorophenyl)methane by-product. The complex is broken by quenching the reaction mass with a Lewis acid-solvating liquid to liberate 4-fluorobenzaldehyde. By-product halobis(fluorophenyl)methane is converted to di(fluorophenyl)methanol to avoid potential corrosion problems and formation of light-sensitive color bodies in the recovered 4-fluorobenzaldehyde.

4-Fluorobenzaldehyde Preparation Products And Raw materials

Raw materials

4-Chlorobenzaldehyde p-Fluorotoluene Benzyl dichloride 4-Chlorotoluene

Preparation Products

4-N-PROPOXYBENZALDEHYDE 4-Pyrazol-1-yl-benzaldehyde 3-Bromo-4-fluorobenzaldehyde 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide 4-Fluorobenzoic acid (5-Fluoro-2-methyl-1H-inden-3-yl)acetic acid Rosiglitazone 4-Fluorocinnamic acid DL-3-(4-Fluorophenyl)alanine 4-(1H-Imidazol-1-yl)benzaldehyde 4-Fluoro-3-phenoxybenzaldehyde
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View Lastest Price from 4-Fluorobenzaldehyde manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
4-Fluorobenzaldehyde 459-57-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-02
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
4-Fluorobenzaldehyde 459-57-4
Price
US $70.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Fluorobenzaldehyde 459-57-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-28

459-57-4, 4-FluorobenzaldehydeRelated Search:

4-Fluorobenzoic acid Florfenicol 3-Fluorobenzaldehyde Pentafluorobenzaldehyde 4-Bromofluorobenzene 2,6-Difluorobenzaldehyde Ethyl 4-fluorobenzoate Transfluthrin 1,2-Difluorobenzene 4-Fluoroanisole 4-Fluorobenzoyl chloride 4-Fluorothiophenol 4-Fluoronitrobenzene 4-Fluorobenzyl alcohol 4-Methylbenzyl chloride 4-Chlorobenzaldehyde p-Fluorotoluene 4-Fluoromandelic acid

  • JACS-459-57-4
  • 4-Fluorobenzaldehyde, p-Fluorobenzaldehyde, Benzaldehyde 4-fluoro-, 4-fluoro-benzaldehyde
  • Paroxetine Impurity 58
  • 4-fluoro-benzaldehyd
  • Benzaldehyde, p-fluoro-
  • PFAD
  • PFBA
  • P-FLUOROBENZALDEHYDE
  • PARA FLUOROBENZALDEHYDE
  • FLUOROBENZALDEHYDE(4-)
  • LABOTEST-BB LT00930357
  • AKOS BBS-00003166
  • p-Fluorobenzaldehyde 4-Fluorobenzaldehyde
  • 4-Fluorobenzaldehyde,98%
  • Benzaldehyde, 4-fluoro-
  • 4-Fluorobenzaldehyde99%
  • 4-Fluorbenzaldehyd
  • 4-FLUORO-BENZALDEHYDE 99.5%
  • 19) PARA FLUORO BENZALDEHYDE
  • P-FLUORBENZALDEHYDE
  • 4-FLUOROBENZALDEHYDE
  • 4-Fluorobenzaldehyde≥ 99% (GC)
  • p-Fluoro benzaldehyd
  • 4-Fluorobenzaldehyde, AcroSeal, 98+%
  • 4-Fluorobenzaldehyde for synthesis
  • 4-Fluorobenzaldehyde, 98+%, AcroSeal
  • 4-Fluorobenzaldehyde, 98+% 250ML
  • 4-Fluorobenzaldehyde, 98+% 50ML
  • p-Fluorobenzenecarboxaldehyde
  • NSC 68095
  • Benzaldehyde, p-fluoro- (6CI,7CI,8CI)
  • p-Fluoro benzaldehy
  • The fluoro benzaldehyde
  • Retigabine Genotoxic Impurity 3: 4-Fluorobenzaldehyde
  • 4-Fluorobenzaldehyde&gt
  • Atorvastatin Impurity 195
  • p-Fluorobenzenecarboxaldehyde (Atorvastatin calcium)
  • 4-Fluorobenzaldehyde pure, 98%
  • 4-Fluorobenzaldehyde, 98+%, AcroSeal&trade
  • Atorvastatin Impurity 112
  • 4-Fluorobenzaldehyde CAS.459-57-4
  • 4-Fluoro-4-methylacetophenone
  • 4-Fluorobenzaldehyde， ≥ 97.0%
  • Atorvastatin calcium impurity 69
  • 459-57-4
  • 459-57-0
  • 2615-30-4
  • Organic Building Blocks
  • C7
  • Carbonyl Compounds
  • Aldehydes
  • Building Blocks
  • Aldehydes
  • C7
  • Carbonyl Compounds
  • Fluoro-Aromatics
  • Benzaldehyde
  • Fluorobenzene