ChemicalBook > CAS DataBase List > 4-(Trifluoromethoxy)benzoic acid

4-(Trifluoromethoxy)benzoic acid

Product Name: 4-(Trifluoromethoxy)benzoic acid
CAS No.: 330-12-1
Chemical Name: 4-(Trifluoromethoxy)benzoic acid
Synonyms: AKOS BBS-00006470;RARECHEM AL BO 0419;TIMTEC-BB SBB000455;uoromethoxy)benzoic Acid;a,a,a-trifluoro-p-anisic acid;P-TRIFLUOROMETHOXYBENZOIC ACID;Anti-Trifluoroxide Benzoic Acids;4-(TRIFLUOROMETHOXY)BENZOIC ACID;For trifluoromethoxy benzoic acid;4-TRIFLUOROMETHOXYBENZOIC ACID-D4
CBNumber: CB6403100
Molecular Formula: C8H5F3O3
Formula Weight: 206.12
MOL File: 330-12-1.mol

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4-(Trifluoromethoxy)benzoic acid Property

Melting point:: 150-154 °C(lit.)
Boiling point:: 203°C (rough estimate)
Density: 1.4251 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Powder
pka: 3.85±0.10(Predicted)
color: White to cream
BRN: 977356
InChI: InChI=1S/C8H5F3O3/c9-8(10,11)14-6-3-1-5(2-4-6)7(12)13/h1-4H,(H,12,13)
InChIKey: RATSANVPHHXDCT-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference: 330-12-1(CAS DataBase Reference)
NIST Chemistry Reference: 4-(Trifluoromethoxy)benzoic acid(330-12-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 301396
Product name: 4-(Trifluoromethoxy)benzoic acid
Purity: 96%
Packaging: 1g
Price: $42
Updated: 2022/05/15

TCI Chemical

Product number: T1400
Product name: 4-(Trifluoromethoxy)benzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: T1400
Product name: 4-(Trifluoromethoxy)benzoic Acid
Purity: min. 97.0 %
Packaging: 25G
Price: $231
Updated: 2025/07/31

TCI Chemical

Product number: T1400
Product name: 4-(Trifluoromethoxy)benzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $77
Updated: 2025/07/31

TRC

Product number: T790720
Product name: 4-(Trifluoromethoxy)benzoic Acid
Packaging: 5g
Price: $130
Updated: 2021/12/16

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4-(Trifluoromethoxy)benzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

4-(Trifluoromethoxy)benzoic Acid is a substituted benzoic acid used in the preparation of a various biologically active compounds such as antifungal and antimalarial agents.

General Description

Kinetics of internal acyl migration and hydrolysis of the synthetic β-1-O-acyl-D-glucopyranuronates of 2-, 3-, and 4-(trifluoromethyl)benzoic acids in phosphate buffer was studied.

Synthesis

332-25-2

330-12-1

Synthesis of 4-(trifluoromethoxy)benzoic acid: 4-(trifluoromethoxy)benzonitrile (4 g, 21.4 mmol) was dissolved in acetic acid (12 mL), and water (12 mL) and concentrated sulfuric acid (12 mL) were added sequentially. The reaction mixture was stirred and reacted at 120 °C overnight. Upon completion of the reaction, water (100 mL) was added to the mixture and the aqueous phase was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound 4-(trifluoromethoxy)benzoic acid (4.8 g, 98% yield) as a white solid.

References

[1] Patent: US2007/270434, 2007, A1. Location in patent: Page/Page column 16-17

4-(Trifluoromethoxy)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(Trifluoromethoxy)benzoic acid manufacturers

Career Henan Chemical Co

Product: 4-(Trifluoromethoxy)benzoic acid 330-12-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

330-12-1, 4-(Trifluoromethoxy)benzoic acidRelated Search:

4-(Trifluoromethoxy)aniline Trimethyl phosphite 2-(Trifluoromethyl)benzoic acid 4-(Trifluoromethyl)benzoic acid 3-(Trifluoromethoxy)aniline 2-(Trifluoromethoxy)aniline 4-(Trifluoromethoxy)benzaldehyde p-Anisidine 4-Methoxybenzoic acid p-Trifluoromethoxy phenol 4-(Trifluoromethoxy)chlorobenzene (Trifluoromethoxy)benzene Anisole 4'-(Trifluoromethoxy)acetophenone 4-Aminobenzotrifluoride 4-Trifluoromethylphenol 4-(Trifluoromethoxy)benzyl chloride 4-(Trifluoromethyl)phenylacetic acid

RARECHEM AL BO 0419

P-TRIFLUOROMETHYL CARBOXYPHENYL ETHER

P-TRIFLUOROMETHOXYBENZOIC ACID

TIMTEC-BB SBB000455

4-(Trifluoromethoxy)benzoic acid 97%

4-(Trifluoromethoxy)benzoicacid97%

4-(Trifluoromethoxy)benzoic acid, 98+%

Anti-Trifluoroxide Benzoic Acids

a,a,a-trifluoro-p-anisic acid

4-(Trifluoromethoxy)benzoic acid,99%

For trifluoromethoxy benzoic acid

AKOS BBS-00006470

ALPHA,ALPHA,ALPHA-TRIFLUORO-P-ANISIC ACID

4-(TRIFLUOROMETHOXY)BENZOIC ACID

P-CARBOXYPHENYL TRIFLUOROMETHYL ETHER

Benzoic acid, 4-(trifluoromethoxy)-

uoromethoxy)benzoic Acid

4-TRIFLUOROMETHOXYBENZOIC ACID-D4

330-12-1

C8H5F3O3

ARYL ACID

Organic Building Blocks

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Benzoic acid series

Carbonyl Compounds

Carboxylic Acids

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts