Z-DEVD-FMK

Product Name: Z-DEVD-FMK
CAS No.: 210344-95-9
Chemical Name: Z-DEVD-FMK
Synonyms: S7312;CS-1505;CTK8E8674;abs812077;Z-DEVD-FMK;AG-B-56189;CASPASE-3, INHIBITOR;CASPASE-3 INHIBITOR2;Z-DEVD-FMK USP/EP/BP;CASPASE-3 INHIBITOR II
CBNumber: CB6453635
Molecular Formula: C30H41FN4O12
Formula Weight: 668.66
MOL File: Mol file

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Z-DEVD-FMK Property

Boiling point:: 914.2±65.0 °C(Predicted)
Density: 1.260±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO/DMF: ≥20 mM
form: White to slightly brown solid
pka: 10.26±0.46(Predicted)
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 264155
Product name: Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
Purity: The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 250μG
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: 264155
Product name: Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
Packaging: 1mg
Price: $417
Updated: 2024/03/01

Cayman Chemical

Product number: 14414
Product name: Z-DEVD-FMK
Purity: ≥95%
Packaging: 500μg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 14414
Product name: Z-DEVD-FMK
Purity: ≥95%
Packaging: 1mg
Price: $210
Updated: 2024/03/01

Cayman Chemical

Product number: 14414
Product name: Z-DEVD-FMK
Purity: ≥95%
Packaging: 5mg
Price: $820
Updated: 2024/03/01

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Z-DEVD-FMK Chemical Properties,Usage,Production

Uses

Z-DEVD-FMK is an irrversible caspase-3 inhibitor used as an anaesthetic agent. In addition, it is proposed to increase the longevity of platelet storage.

Definition

ChEBI: Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent.

General Description

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 μg/75 μl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.

Biological Activity

Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo .

Biochem/physiol Actions

Cell permeable: yes

target

Caspase-3

References

1. garcia-calvo m, peterson ep, leiting b, ruel r, nicholson dw, thornberry na (1998) inhibition of human caspases by peptidebased and macromolecular inhibitors. j biol chem 273:32608–32613 2. thornberry na, rano ta, peterson ep, rasper dm, timkey t, garcia-calvo m, houtzager vm, nordstrom pa, roy s, vaillancourt jp, chapman kt, nicholson dw (1997) a combinatorial approach defines specificities of members of the caspase family and granzyme b. functional relationships established for key mediators of apoptosis. j biol chem 272:17907–17911 3. yakovlev ag, knoblach sm, fan l, fox gb, goodnight r, faden ai (1997) activation of cpp32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. j neurosci 17:7415–7424 4. clark rs, kochanek pm, watkins sc, chen m, dixon ce, seidberg na, melick j, loeffert je, nathaniel pd, jin kl, graham sh (2000) caspase-3 mediated neuronal death after traumatic brain injury in rats. j neurochem 74:740–753 5. s. m. knoblach, d. a. alroy et al, caspase inhibitor z-devd-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury, journal of cerebral blood flow & metabolism 24:1119–1132.

Z-DEVD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-DEVD-FMK Suppliers

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210344-95-9, Z-DEVD-FMKRelated Search:

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Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE

Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-CH2F

Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE

Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK

Z-ASP(OME)-GLU(OME)-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE

Z-DEVD-FLUOROMETHYLKETONE

Z-DEVD-FMK

Z-D(OME)E(OME)VD(OME) FLUOROMETHYLKETONE

Z-D(OME)E(OME)VD(OME)-FMK

BENZYLOXYCARBONYL-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE

CASPASE3/CPP32 INHIBITOR W-3

CASPASE-3, INHIBITOR

CASPASE-3 INHIBITOR2

Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

AG-B-56189

CASPASE-3 INHIBITOR II; 210344-95-9; CASPASE-3 INHIBITOR; CTK8E8674; AG-B-56189; S7312;CASPASE-3 INHIBITOR;210344-95-9

CTK8E8674

S7312

CS-1505

CASPASE-3 INHIBITOR (FLUOROMETHYLKETONE)

CASPASE-3 INHIBITOR II

L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester

N-[(Phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide 1,2-dimethyl ester

Caspase-2 Inhibitor Z-VDVAD-FMK

Z-DEVD-FMK USP/EP/BP

abs812077

Z-DEVD-FMK, Caspase-3 inhibitor

CBZ-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OM)

210344-95-9

210334-95-9

C30H41N4O12F

Inhibitors

Apoptosis

peptides

API

Caspases/Apoptosis

peptide

Caspase/Related Products

Pepetides