LCKLSL
- Product Name
- LCKLSL
- CAS No.
- 533902-29-3
- Chemical Name
- LCKLSL
- Synonyms
- LCKLSL;L-Leucine, L-leucyl-L-cysteinyl-L-lysyl-L-leucyl-L-seryl-
- CBNumber
- CB66224574
- Molecular Formula
- C30H57N7O8S
- Formula Weight
- 675.88
- MOL File
- 533902-29-3.mol
LCKLSL Property
- Boiling point:
- 1024.2±65.0 °C(Predicted)
- Density
- 1.185±0.06 g/cm3(Predicted)
- pka
- 3.30±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Leu-Cys-Lys-Leu-Ser-Leu
LCKLSL Chemical Properties,Usage,Production
Uses
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].
in vivo
Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points[1].
References
[1] Mallika Valapala, et al. A Competitive Hexapeptide Inhibitor of Annexin A2 Prevents Hypoxia-Induced Angiogenic Events. J Cell Sci. 2011 May 1;124(Pt 9):1453-64. DOI:10.1242/jcs.079236
LCKLSL Preparation Products And Raw materials
Raw materials
Preparation Products
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