ChemicalBook > CAS DataBase List > 2-Chloro-3-fluoro-4-iodopyridine

2-Chloro-3-fluoro-4-iodopyridine

Product Name
2-Chloro-3-fluoro-4-iodopyridine
CAS No.
148639-07-0
Chemical Name
2-Chloro-3-fluoro-4-iodopyridine
Synonyms
2-CHLORO-3-FLUORO-4-IODOPYRIDINE;Pyridine, 2-chloro-3-fluoro-4-iodo-;2-Chloro-3-fluoro-4-iodopyridine 95+%;2-CHLORO-3-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH
CBNumber
CB7225275
Molecular Formula
C5H2ClFIN
Formula Weight
257.43
MOL File
148639-07-0.mol
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2-Chloro-3-fluoro-4-iodopyridine Property

Melting point:
97 °C
Boiling point:
246.1±35.0 °C(Predicted)
Density 
2.129±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-0.22±0.10(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C5H2ClFIN/c6-5-4(7)3(8)1-2-9-5/h1-2H
InChIKey
GONULLRFSHKLBS-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(I)=C1F
CAS DataBase Reference
148639-07-0(CAS DataBase Reference)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3375
Product name
2-Chloro-3-fluoro-4-iodopyridine
Packaging
1G
Price
$144
Updated
2025/07/31
TRC
Product number
C368263
Product name
2-Chloro-3-fluoro-4-iodopyridine
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
W3243
Product name
2-Chloro-3-fluoro-4-iodopyridine
Packaging
1g
Price
$99
Updated
2021/12/16
Ark Pharm
Product number
AK-33366
Product name
2-Chloro-3-fluoro-4-iodopyridine
Purity
95%
Packaging
1g
Price
$20
Updated
2021/12/16
Matrix Scientific
Product number
071628
Product name
2-Chloro-3-fluoro-4-iodopyridine
Purity
98%
Packaging
1g
Price
$40
Updated
2021/12/16
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2-Chloro-3-fluoro-4-iodopyridine Chemical Properties,Usage,Production

Uses

2-Chloro-3-fluoro-4-iodopyridine is a polyhalogenated compound with a wide uses. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

17282-04-1

148639-07-0

The general procedure for the synthesis of 2-chloro-3-fluoro-4-iodopyridine using 2-chloro-3-fluoropyridine as a starting material was as follows: a lithium 2-diisopropylammonium solution (2M, dissolved in a mixed solvent of tetrahydrofuran/ethylbenzene/heptane, 155 mL, 0.31 mol) was added slowly and dropwise over a period of 40 min at -70 °C to a 2-chloro-3-fluoropyridine (31 g, 0.235 mol) tetrahydrofuran (200 mL) solution. After the dropwise addition, the reaction mixture was continued to be stirred at -70 °C for 4 hours. Subsequently, a solution of iodine (69 g, 0.2 mol) in tetrahydrofuran (100 mL) was added dropwise over a period of 30 min, and after keeping the reaction at -70 °C for 30 min, the reaction was slowly warmed up to room temperature, and the warming up process was controlled to be completed in 1 hour. The reaction mixture was poured into aqueous sodium bisulfite solution (20% v/v, 2 L) and extracted with ether (3 x 300 mL). The organic phases were combined and washed sequentially with aqueous sodium metabisulfite (20% v/v, 2L) and water (200 mL), dried with anhydrous sodium sulfate and concentrated under reduced pressure to give a colorless oily substance. The oily material was ground with ether to afford the target product 2-chloro-3-fluoro-4-iodopyridine as a reddish brown solid (28 g, 46% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 7.87 (d, J=5.0 Hz, 1H), 7.66 (ddd, J=5.0,4.0,0.4 Hz, 1H).

References

[1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 107-108
[2] Tetrahedron, 1993, vol. 49, # 16, p. 3325 - 3342

2-Chloro-3-fluoro-4-iodopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-3-fluoro-4-iodopyridine Suppliers

Americas 1 China 156 Europe 1 Germany 1 India 6 Japan 1 United Kingdom 2 United States 16 Global 184
Pure Chemistry Scientific Inc.
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Matrix Scientific
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View Lastest Price from 2-Chloro-3-fluoro-4-iodopyridine manufacturers

Dideu Industries Group Limited
Product
2-CHLORO-3-FLUORO-4-IODOPYRIDINE 148639-07-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-01
Career Henan Chemical Co
Product
2-CHLORO-3-FLUORO-4-IODOPYRIDINE 148639-07-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-02

148639-07-0, 2-Chloro-3-fluoro-4-iodopyridineRelated Search:

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  • 2-CHLORO-3-FLUORO-4-IODOPYRIDINE
  • 2-Chloro-3-fluoro-4-iodopyridine 95+%
  • Pyridine, 2-chloro-3-fluoro-4-iodo-
  • 2-CHLORO-3-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH
  • 148639-07-0
  • C5H2NClFI
  • C5H2ClFIN
  • Pyridine
  • Boronic Acid
  • Fluorin-contained pyridine series