ChemicalBook > CAS DataBase List > Ethyl 4-piperidinecarboxylate

Ethyl 4-piperidinecarboxylate

Product Name
Ethyl 4-piperidinecarboxylate
CAS No.
1126-09-6
Chemical Name
Ethyl 4-piperidinecarboxylate
Synonyms
ETHYL PIPERIDINE-4-CARBOXYLATE;ETHYL ISONIPECOTATE;4-piperidinecarboxylate;PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER;H-Nip-OEt;H-DL-Inp-OEt;AKOS MSC-0737;RARECHEM AH CK 0180;TIMTEC-BB SBB004006;ETHYL ISONEPECOTATE
CBNumber
CB7231962
Molecular Formula
C8H15NO2
Formula Weight
157.21
MOL File
1126-09-6.mol
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Ethyl 4-piperidinecarboxylate Property

Boiling point:
204 °C(lit.)
Density 
1.02 g/mL at 25 °C(lit.)
vapor pressure 
39.4Pa at 25℃
refractive index 
n20/D 1.459(lit.)
Flash point:
176 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Liquid
pka
9.83±0.10(Predicted)
color 
Clear colorless to slightly brown
Water Solubility 
miscible
BRN 
118419
LogP
1.15
CAS DataBase Reference
1126-09-6(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl piperidine-4-carboxylate(1126-09-6)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
23-24/25-36-26
RIDADR 
UN2735
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E33505
Product name
Ethyl isonipecotate
Purity
98%
Packaging
25g
Price
$51.3
Updated
2024/03/01
Sigma-Aldrich
Product number
E33505
Product name
Ethyl isonipecotate
Purity
98%
Packaging
100g
Price
$148
Updated
2024/03/01
TCI Chemical
Product number
I0294
Product name
Ethyl 4-Piperidinecarboxylate
Purity
>98.0%(GC)
Packaging
25mL
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
I0294
Product name
Ethyl 4-Piperidinecarboxylate
Purity
>98.0%(GC)
Packaging
100mL
Price
$94
Updated
2024/03/01
Alfa Aesar
Product number
B20601
Product name
Ethyl isonipecotate, 98%
Packaging
25g
Price
$40.65
Updated
2024/03/01
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Ethyl 4-piperidinecarboxylate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly brown liquid

Uses

Reactant for synthesis of:• ;SMN protein modulators1• ;β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition2• ;Nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone3• ;RhoA inhibitors for cardiovascular disease therapy4• ;Saccharin derived Mannich bases as antimicrobials and antioxidants5Reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates6

Uses

Reactant for synthesis of SMN protein modulators and β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition.

Uses

It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 193, 1982 DOI: 10.1016/S0040-4039(00)86783-0

Ethyl 4-piperidinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE (R)-3-Aminoquinuclidine dihydrochloride Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate (R)-(-)-3-Quinuclidinol 1-(2,6-DIMETHOXYBENZYL)PIPERIDIN-4-AMINE HYDROCHLORIDE 1-(PYRIMIDIN-2-YL)PIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-Boc-4-methylpiperidine-4-carboxylic acid 3-Quinuclidinone hydrochloride (S)-(+)-3-Quinuclidinol Ethyl N-Boc-4-methylpiperidine-4-carboxylate (S)-3-Aminoquinuclidine dihydrochloride 3-Aminoquinuclidine dihydrochloride 1-(PYRIMIDIN-2-YL)PIPERIDINE-3-CARBOHYDRAZIDE Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)pyrimidine-5-carboxylate quinuclidine-3-carboxylic acid (R)-3-Quinuclidinol hydrochloride
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View Lastest Price from Ethyl 4-piperidinecarboxylate manufacturers

Henan Fengda Chemical Co., Ltd
Product
Ethyl 4-piperidinecarboxylate 1126-09-6
Price
US $8.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-29
PNP Biotech Co. Ltd
Product
Ethyl piperidine-4-carboxylate 1126-09-6
Price
US $0.00/kg
Min. Order
25kg
Purity
≥98%
Supply Ability
Inquiry
Release date
2022-10-28
Hebei Kingfiner Technology Development Co.Ltd
Product
Ethyl piperidine-4-carboxylate 1126-09-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2023-12-21

1126-09-6, Ethyl 4-piperidinecarboxylateRelated Search:

ETHYL 4-PIPERIDINECARBOXYLATE HYDROCHLORIDE,ETHYL 4-PIPERIDINECARBOXYLATE HCL Ethyl nipecotate hydrochloride(Ethyl 3-Piperidinecarboxylate hydrochloride) Isonipecotic acid 1-PIPERIDINECARBONYL CHLORIDE 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Hexahydroisonicotinamide Methyl 4-piperidinecarboxylate 4-Piperidinemethanol 4,4-Piperidinediol hydrochloride 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER MEPERIDINE Ethyl 1-methyl-4-piperidinecarboxylate ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE Ethyl 4-piperidinecarboxylate DIPHENOXYLATE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE Ethyl 4-(ethoxycarbonyl)piperidine-1-acetate Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride

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  • Ethyl isonipecotate, 4-(Ethoxycarbonyl)piperidine
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  • LABOTEST-BB LT00159543
  • 4-PIPERDINECARBOXYLIC ACID, ETHYL ESTER
  • 4-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
  • AKOS MSC-0737
  • RARECHEM AH CK 0180
  • PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
  • TIMTEC-BB SBB004006
  • Ethyl Isonipecotate(ethyl 4-Piperidinecarboxylate)
  • Hexahydroisonicotinic acid, ethyl ester
  • Ethyl isonipecotate, 98+%
  • Ethyl piperidine-4-carboxylate 97%
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  • H-DL-Inp-OEt
  • H-Nip-OEt
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  • Isopecoticacidethylester
  • Piperidin-4-carboxylic acid ethyl ester
  • 4-(Ethoxycarbonyl)piperidine
  • Ethyl piperidine-4-carboxylate ,97%
  • Isonipecotic acid ethyl
  • Piperidine-4-carboxylic acid ethyl
  • Ethyl isonipcotinate
  • Ethyl4-Piperidinecarboxylate&gt
  • Avatrombopag Impurity 11
  • ETHYL ISONEPECOTATE
  • Ethyl isohipecotate
  • Piperidine-4-carboxylate, ethyl ester
  • 1-(1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carbonyl) piperidine-4-carboxylic acid
  • Avatroposide impurities17
  • Avatrapa impurity 11
  • 4-Piperidinecarboxylic Acid Ethyl Ester (Ethyl isonipecotate)
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