Ethyl 4-piperidinecarboxylate

Product Name: Ethyl 4-piperidinecarboxylate
CAS No.: 1126-09-6
Chemical Name: Ethyl 4-piperidinecarboxylate
Synonyms: ETHYL PIPERIDINE-4-CARBOXYLATE;ETHYL ISONIPECOTATE;4-piperidinecarboxylate;PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER;H-Nip-OEt;H-DL-Inp-OEt;AKOS MSC-0737;RARECHEM AH CK 0180;TIMTEC-BB SBB004006;ETHYL ISONEPECOTATE
CBNumber: CB7231962
Molecular Formula: C8H15NO2
Formula Weight: 157.21
MOL File: 1126-09-6.mol

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Ethyl 4-piperidinecarboxylate Property

Boiling point:: 204 °C(lit.)
Density: 1.02 g/mL at 25 °C(lit.)
vapor pressure: 39.4Pa at 25℃
refractive index: n20/D 1.459(lit.)
Flash point:: 176 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Liquid
pka: 9.83±0.10(Predicted)
color: Clear colorless to slightly brown
Water Solubility: miscible
BRN: 118419
LogP: 1.15
CAS DataBase Reference: 1126-09-6(CAS DataBase Reference)
NIST Chemistry Reference: Ethyl piperidine-4-carboxylate(1126-09-6)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/37/38
Safety Statements: 23-24/25-36-26
RIDADR: UN2735
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E33505
Product name: Ethyl isonipecotate
Purity: 98%
Packaging: 25g
Price: $51.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: E33505
Product name: Ethyl isonipecotate
Purity: 98%
Packaging: 100g
Price: $148
Updated: 2024/03/01

TCI Chemical

Product number: I0294
Product name: Ethyl 4-Piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 25mL
Price: $36
Updated: 2024/03/01

TCI Chemical

Product number: I0294
Product name: Ethyl 4-Piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 100mL
Price: $94
Updated: 2024/03/01

Alfa Aesar

Product number: B20601
Product name: Ethyl isonipecotate, 98%
Packaging: 25g
Price: $40.65
Updated: 2024/03/01

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Ethyl 4-piperidinecarboxylate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly brown liquid

Uses

Reactant for synthesis of:• ;SMN protein modulators1• ;β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition2• ;Nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone3• ;RhoA inhibitors for cardiovascular disease therapy4• ;Saccharin derived Mannich bases as antimicrobials and antioxidants5Reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates6

Uses

Reactant for synthesis of SMN protein modulators and β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition.

Uses

It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 193, 1982 DOI: 10.1016/S0040-4039(00)86783-0

Ethyl 4-piperidinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE (R)-3-Aminoquinuclidine dihydrochloride Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate (R)-(-)-3-Quinuclidinol 1-(2,6-DIMETHOXYBENZYL)PIPERIDIN-4-AMINE HYDROCHLORIDE 1-(PYRIMIDIN-2-YL)PIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-Boc-4-methylpiperidine-4-carboxylic acid 3-Quinuclidinone hydrochloride (S)-(+)-3-Quinuclidinol Ethyl N-Boc-4-methylpiperidine-4-carboxylate (S)-3-Aminoquinuclidine dihydrochloride 3-Aminoquinuclidine dihydrochloride 1-(PYRIMIDIN-2-YL)PIPERIDINE-3-CARBOHYDRAZIDE Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)pyrimidine-5-carboxylate quinuclidine-3-carboxylic acid (R)-3-Quinuclidinol hydrochloride

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View Lastest Price from Ethyl 4-piperidinecarboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl 4-piperidinecarboxylate 1126-09-6
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-07-14

Hebei Kingfiner Technology Development Co.Ltd

Product: Ethyl piperidine-4-carboxylate 1126-09-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500000kg
Release date: 2023-12-21

Anhui Yiao New Material Technology Co., Ltd

Product: Ethyl 4-piperidinecarboxylate 1126-09-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

1126-09-6, Ethyl 4-piperidinecarboxylateRelated Search:

ETHYL 4-PIPERIDINECARBOXYLATE HYDROCHLORIDE,ETHYL 4-PIPERIDINECARBOXYLATE HCL Ethyl nipecotate hydrochloride(Ethyl 3-Piperidinecarboxylate hydrochloride) Isonipecotic acid 1-PIPERIDINECARBONYL CHLORIDE 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Hexahydroisonicotinamide Methyl 4-piperidinecarboxylate 4-Piperidinemethanol 4,4-Piperidinediol hydrochloride 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER MEPERIDINE Ethyl 1-methyl-4-piperidinecarboxylate ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE Ethyl 4-piperidinecarboxylate DIPHENOXYLATE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE Ethyl 4-(ethoxycarbonyl)piperidine-1-acetate Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride

4-Carbethoxypiperidine

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Ethyl isonipecotate ,97%

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ethyl piperidin-4-carboxylate

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4-Carboethoxypiperidine

ISONIPECOTIC ACID ETHYL ESTER

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ETHYL 4-PIPERIDINECARBOXYLATE

LABOTEST-BB LT00159543

4-PIPERDINECARBOXYLIC ACID, ETHYL ESTER

4-PIPERIDINECARBOXYLIC ACID ETHYL ESTER

AKOS MSC-0737

RARECHEM AH CK 0180

PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER

TIMTEC-BB SBB004006

Ethyl Isonipecotate(ethyl 4-Piperidinecarboxylate)

Hexahydroisonicotinic acid, ethyl ester

Ethyl isonipecotate, 98+%

Ethyl piperidine-4-carboxylate 97%

Ethyl 4-Piperidinecarboxylate (Ethyl isonipecotate)

H-DL-Inp-OEt

H-Nip-OEt

PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER, ISONIPECOTINIC ACID ETHYL ESTER

Isopecoticacidethylester

Piperidin-4-carboxylic acid ethyl ester

4-(Ethoxycarbonyl)piperidine

Ethyl piperidine-4-carboxylate ,97%

Isonipecotic acid ethyl

Piperidine-4-carboxylic acid ethyl

Ethyl isonipcotinate

Ethyl4-Piperidinecarboxylate&gt

Avatrombopag Impurity 11

ETHYL ISONEPECOTATE

Ethyl isohipecotate

Piperidine-4-carboxylate, ethyl ester

1-(1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carbonyl) piperidine-4-carboxylic acid

Avatroposide impurities17

Avatrapa impurity 11

4-Piperidinecarboxylic Acid Ethyl Ester (Ethyl isonipecotate)

Ethyl 4-piperoxyformate

Impurity 15 of pentaethyl quinone hydrochloride

1126-09-6

1123-09-6

Heterocyclic Building Blocks

Piperidines