Ethyl 4-piperidinecarboxylate

Product Name: Ethyl 4-piperidinecarboxylate
CAS No.: 1126-09-6
Chemical Name: Ethyl 4-piperidinecarboxylate
Synonyms: ETHYL PIPERIDINE-4-CARBOXYLATE;ETHYL ISONIPECOTATE;4-piperidinecarboxylate;PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER;H-Nip-OEt;H-DL-Inp-OEt;AKOS MSC-0737;RARECHEM AH CK 0180;TIMTEC-BB SBB004006;ETHYL ISONEPECOTATE
CBNumber: CB7231962
Molecular Formula: C8H15NO2
Formula Weight: 157.21
MOL File: 1126-09-6.mol

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Ethyl 4-piperidinecarboxylate Property

Boiling point:: 204 °C(lit.)
Density: 1.02 g/mL at 25 °C(lit.)
vapor pressure: 39.4Pa at 25℃
refractive index: n20/D 1.459(lit.)
Flash point:: 176 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Liquid
pka: 9.83±0.10(Predicted)
color: Clear colorless to slightly brown
Water Solubility: miscible
BRN: 118419
InChI: InChI=1S/C8H15NO2/c1-2-11-8(10)7-3-5-9-6-4-7/h7,9H,2-6H2,1H3
InChIKey: RUJPPJYDHHAEEK-UHFFFAOYSA-N
SMILES: N1CCC(C(OCC)=O)CC1
LogP: 1.15
CAS DataBase Reference: 1126-09-6(CAS DataBase Reference)
NIST Chemistry Reference: Ethyl piperidine-4-carboxylate(1126-09-6)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/37/38
Safety Statements: 23-24/25-36-26
RIDADR: UN2735
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E33505
Product name: Ethyl isonipecotate
Purity: 98%
Packaging: 25g
Price: $42.16
Updated: 2025/07/31

Sigma-Aldrich

Product number: E33505
Product name: Ethyl isonipecotate
Purity: 98%
Packaging: 100g
Price: $153
Updated: 2025/07/31

TCI Chemical

Product number: I0294
Product name: Ethyl 4-Piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 25mL
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: I0294
Product name: Ethyl 4-Piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 100mL
Price: $94
Updated: 2025/07/31

TCI Chemical

Product number: I0294
Product name: Ethyl 4-Piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 500mL
Price: $279
Updated: 2025/07/31

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Ethyl 4-piperidinecarboxylate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly brown liquid

Uses

Reactant for synthesis of:• ;SMN protein modulators1• ;β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition2• ;Nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone3• ;RhoA inhibitors for cardiovascular disease therapy4• ;Saccharin derived Mannich bases as antimicrobials and antioxidants5Reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates6

Uses

Reactant for synthesis of SMN protein modulators and β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition.

Uses

It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 193, 1982 DOI: 10.1016/S0040-4039(00)86783-0

Synthesis

498-94-2

64-17-5

1126-09-6

1. 4-Piperidinecarboxylic acid (1.29 g, 10.0 mmol) was dissolved in anhydrous ethanol (50 mL). 2. The reaction solution was cooled to 0 °C and thionyl chloride (2.91 mL, 40.0 mmol) was added slowly and dropwise. 3. The reaction mixture was stirred and heated to reflux for 48 hours. 4. After completion of the reaction, the solvent was evaporated under reduced pressure to give a yellow oily crude product. 5. The crude product was dissolved in ethyl acetate (EtOAc) and washed with 10% sodium hydroxide (NaOH) solution. 6. The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the clarified oily product ethyl 4-piperidinecarboxylate (1.48 g, 94% yield). 7. The product was analyzed by 1H NMR. 7. The product was characterized by 1H NMR (400 MHz, CDCl3) and mass spectrometry (ESI) to confirm the correct structure.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 23, p. 7106 - 7109
[2] Letters in Organic Chemistry, 2015, vol. 12, # 4, p. 277 - 279
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983, vol. 22, # 5, p. 505
[4] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 18, p. 2693 - 2698
[5] European Journal of Medicinal Chemistry, 2000, vol. 35, # 7-8, p. 699 - 706

Ethyl 4-piperidinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE (R)-3-Aminoquinuclidine dihydrochloride Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate (R)-(-)-3-Quinuclidinol 1-(2,6-DIMETHOXYBENZYL)PIPERIDIN-4-AMINE HYDROCHLORIDE 1-(PYRIMIDIN-2-YL)PIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-Boc-4-methylpiperidine-4-carboxylic acid 3-Quinuclidinone hydrochloride (S)-(+)-3-Quinuclidinol Ethyl N-Boc-4-methylpiperidine-4-carboxylate (S)-3-Aminoquinuclidine dihydrochloride 3-Aminoquinuclidine dihydrochloride 1-(PYRIMIDIN-2-YL)PIPERIDINE-3-CARBOHYDRAZIDE Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)pyrimidine-5-carboxylate quinuclidine-3-carboxylic acid (R)-3-Quinuclidinol hydrochloride

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View Lastest Price from Ethyl 4-piperidinecarboxylate manufacturers

Moxin Chemicals

Product: Avatrombopag Impurity 46 1126-09-6
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%+
Supply Ability: 100000
Release date: 2025-02-10

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl 4-piperidinecarboxylate 1126-09-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 4-piperidinecarboxylate 1126-09-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-13

1126-09-6, Ethyl 4-piperidinecarboxylateRelated Search:

ETHYL 4-PIPERIDINECARBOXYLATE HYDROCHLORIDE,ETHYL 4-PIPERIDINECARBOXYLATE HCL Isonipecotic acid 1-PIPERIDINECARBONYL CHLORIDE 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Hexahydroisonicotinamide Methyl 4-piperidinecarboxylate 4-Piperidinemethanol 4,4-Piperidinediol hydrochloride Methyl isonipecotate 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER MEPERIDINE Ethyl 1-methyl-4-piperidinecarboxylate ETHYL 1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLATE Ethyl 4-piperidinecarboxylate DIPHENOXYLATE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE Ethyl 4-(ethoxycarbonyl)piperidine-1-acetate Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride

4-Carbethoxypiperidine

ISONIPECOTINIC ACID ETHYL ESTER

Ethyl isonipecotate ,97%

1-ethylpiperidine-4-carboxylate

ethyl piperidin-4-carboxylate

Ethyl isonipecotate, 98+% 100GR

Ethyl isonipecotate, 98+% 25GR

Ethyl Isonipecotate Isonipecotic Acid Ethyl Ester 4-Piperidinecarboxylic Acid Ethyl Ester

Ethyl isonipecotate, 4-(Ethoxycarbonyl)piperidine

4-piperidine forMic acid ethyl ester

Ethyl isonipecotate 98%

Ethyl 4-Piperidinecarboxylate, 97.0%

4 - piperidine ethyl forMate

Ethyl 4-piperidinecarboxylate for synthesis

Ethyl 4-piperidinecarboxylate ESTER

4-piperidinecarboxylate

4-Carboethoxypiperidine

ISONIPECOTIC ACID ETHYL ESTER

ETHYL ISONIPECOTATE

ETHYL PIPERIDINE-4-CARBOXYLATE

ETHYL 4-PIPERIDINECARBOXYLATE

LABOTEST-BB LT00159543

4-PIPERDINECARBOXYLIC ACID, ETHYL ESTER

4-PIPERIDINECARBOXYLIC ACID ETHYL ESTER

AKOS MSC-0737

RARECHEM AH CK 0180

PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER

TIMTEC-BB SBB004006

Ethyl Isonipecotate(ethyl 4-Piperidinecarboxylate)

Hexahydroisonicotinic acid, ethyl ester

Ethyl isonipecotate, 98+%

Ethyl piperidine-4-carboxylate 97%

Ethyl 4-Piperidinecarboxylate (Ethyl isonipecotate)

H-DL-Inp-OEt

H-Nip-OEt

PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER, ISONIPECOTINIC ACID ETHYL ESTER

Isopecoticacidethylester

Piperidin-4-carboxylic acid ethyl ester

4-(Ethoxycarbonyl)piperidine

Ethyl piperidine-4-carboxylate ,97%

Isonipecotic acid ethyl

Piperidine-4-carboxylic acid ethyl

Ethyl isonipcotinate

Ethyl4-Piperidinecarboxylate&gt

Avatrombopag Impurity 11

ETHYL ISONEPECOTATE

Ethyl isohipecotate

Piperidine-4-carboxylate, ethyl ester

1-(1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carbonyl) piperidine-4-carboxylic acid

Avatroposide impurities17

4-Piperidinecarboxylic Acid Ethyl Ester (Ethyl isonipecotate)

Ethyl 4-piperoxyformate

Avatrhopal impurity 46

Avatrapa impurity 11

Impurity 15 of pentaethyl quinone hydrochloride

4-Piperidine Carboxylic Acide Ethyl Ester

1126-09-6

1123-09-6