Propargyl-PEG5-NHS ester
- Product Name
- Propargyl-PEG5-NHS ester
- CAS No.
- 1393330-40-9
- Chemical Name
- Propargyl-PEG5-NHS ester
- Synonyms
- Alkyne-PEG5-NHS;Propargyl-PEG4-Osu;Alkyne-PEG4-NHS Ester;Propargyl-PEG5-NHS ester;Propargyl-PEG4-CH2CH2COONHS;Propargyl-PEG4-C2-CONHS ester;Alkyne-PEG4-NHS Ester (CCT-TA103);4,7,10,13,16-Pentaoxanonadec-18-ynoic Acid N-Succinimidyl Ester;2,5-dioxopyrrolidin-1-yl 4,7,10,13,16-pentaoxanonadec-18-ynoate;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16-pentaoxanonadec-18-yn-1-oate
- CBNumber
- CB73049423
- Molecular Formula
- C18H27NO9
- Formula Weight
- 401.41
- MOL File
- 1393330-40-9.mol
Propargyl-PEG5-NHS ester Property
- Boiling point:
- 497.6±55.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- DMSO : 100 mg/mL (249.12 mM; Need ultrasonic)
- form
- clear liquid
- color
- Light yellow to Brown
- Appearance
- Light yellow oil
Safety
- HS Code
- 2925.19.9100
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P2283
- Product name
- Propargyl-PEG5-NHS Ester
- Packaging
- 25mg
- Price
- $173
- Updated
- 2025/07/31
- Product number
- P839538
- Product name
- Propargyl-PEG5-NHS Ester
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 35117
- Product name
- Alkyne-PEG4-NHSester,≥95%(HPLC)
- Purity
- ≥95%(HPLC)
- Packaging
- 5MG
- Price
- $93.18
- Updated
- 2021/12/16
- Product number
- BP-20907
- Product name
- Propargyl-PEG5-NHS Ester
- Purity
- 98%
- Packaging
- 1g
- Price
- $780
- Updated
- 2021/12/16
- Product number
- 35117
- Product name
- Alkyne-PEG4-NHSester,95%(HPLC)
- Purity
- 95%(HPLC)
- Packaging
- 100MG
- Price
- $985.6
- Updated
- 2021/12/16
Propargyl-PEG5-NHS ester Chemical Properties,Usage,Production
Description
Propargyl-PEG5-NHS ester has a propargyl group and an NHS ester group. The terminal NHS ester and is an amine reactive moeity which is useful for derivatizing peptides, antibodies, amine coated surfaces etc. The propargyl group can participate in Click Chemistry reactions with azide compounds, copper is needed for catalyzation. The PEG units can enhance the hydrophilicity of the molecule.
Uses
Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG5-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
Cleavable Linker; PEGs; Alkyl/ether
References
[1] Zhenjun Diwu, et al. Polyfluoreno[4,5-cde]oxepine Conjugates and Their Use in Methods of Analyte Detection. US20170275418A1.
Propargyl-PEG5-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG5-NHS ester Suppliers
- Tel
- --
- Fax
- --
- sales-in@tcichemicals.com
- Country
- India
- ProdList
- 6768
- Advantage
- 58
View Lastest Price from Propargyl-PEG5-NHS ester manufacturers
- Product
- Propargyl-PEG5-NHS ester 1393330-40-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-26