ChemicalBook > CAS DataBase List > Bromo-PEG2-CH2CO2tBu

Bromo-PEG2-CH2CO2tBu

Product Name
Bromo-PEG2-CH2CO2tBu
CAS No.
1807518-63-3
Chemical Name
Bromo-PEG2-CH2CO2tBu
Synonyms
Br-PEG2-CH2-Boc;CAS_1807518-63-3;Br-PEG2-CH2COOtBu;Bromo-PEG2-CH2-Boc;Bromo-PEG2-CH2COOtBu;Bromo-PEG2-CH2CO2tBu;t-butyl acetate-PEG2-bromide;t-butyl acetate-PEG2-bromiade;tert-Butyl 2-[2-(2-bromoethoxy)ethoxy]acetate;t-butyl acetate-PEG2-bromide BROMO-PEG2-CH2CO2TBU
CBNumber
CB73062440
Molecular Formula
C10H19BrO4
Formula Weight
283.16
MOL File
1807518-63-3.mol
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Bromo-PEG2-CH2CO2tBu Property

Boiling point:
316.4±22.0 °C(Predicted)
Density 
1.269±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
form 
liquid
color 
Clear
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Safety

HS Code 
2942000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-22261
Product name
Bromo-PEG2-CH2CO2tBu
Purity
98%
Packaging
100mg
Price
$340
Updated
2021/12/16
Apolloscientific
Product number
BIPG1339
Product name
Bromo-PEG2-CH2CO2tBu
Packaging
100mg
Price
$731
Updated
2021/12/16
Acrotein
Product number
B-0862
Product name
Br-PEG2-CH2COOtBu
Purity
97%
Packaging
0.25g
Price
$201.66
Updated
2021/12/16
Acrotein
Product number
B-0862
Product name
Br-PEG2-CH2COOtBu
Purity
97%
Packaging
0.5g
Price
$302.5
Updated
2021/12/16
Acrotein
Product number
B-0862
Product name
Br-PEG2-CH2COOtBu
Purity
97%
Packaging
1g
Price
$458.34
Updated
2021/12/16
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Bromo-PEG2-CH2CO2tBu Chemical Properties,Usage,Production

Description

Bromo-PEG2-CH2CO2tBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bromo-PEG2-CH2CO2tBu Preparation Products And Raw materials

Raw materials

Preparation Products

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Bromo-PEG2-CH2CO2tBu Suppliers

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1807518-63-3, Bromo-PEG2-CH2CO2tBuRelated Search:

Tetrabutyl titanate TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA H2N-PEG8-tBu Bromo-PEG4-CH2COOtBu Amino-PEG10-t-butyl ester AMINO-PEG12-T-BUTYL ESTER H2N-PEG6-tBu Bromo-PEG1-CH2CO2tBu Amino-PEG5-t-butyl ester H2N-PEG2-tBu Bromo-PEG4-t-butyl ester Bromo-PEG2-t-butyl ester H2N-PEG4-tBu Azido-PEG1-CH2CO2tBu Azido-PEG4-t-butyl acetate PEG6-(CH2CO2H)2 Hydroxy-PEG6-CH2CO2tBu Hydroxy-PEG1-CH2CO2tBu

  • Bromo-PEG2-CH2CO2tBu
  • Bromo-PEG2-CH2COOtBu
  • t-butyl acetate-PEG2-bromiade
  • Br-PEG2-CH2COOtBu
  • t-butyl acetate-PEG2-bromide
  • CAS_1807518-63-3
  • tert-Butyl 2-[2-(2-bromoethoxy)ethoxy]acetate
  • Bromo-PEG2-CH2-Boc
  • t-butyl acetate-PEG2-bromide BROMO-PEG2-CH2CO2TBU
  • Bromo-PEG-2-CH2-Boc,BromoPEG2CH2Boc,inhibit,Bromo PEG2 CH2 Boc,PROTAC Linkers,Inhibitor
  • Br-PEG2-CH2COOtBu/Acetic acid, 2-[2-(2-bromoethoxy)ethoxy]-, 1,1-dimethylethyl ester
  • Br-PEG2-CH2-Boc
  • Acetic acid, 2-[2-(2-bromoethoxy)ethoxy]-, 1,1-dimethylethyl ester
  • 1807518-63-3