2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
- Product Name
- 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
- CAS No.
- 876310-60-0
- Chemical Name
- 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
- Synonyms
- RD9;RF 9;RF 9 TFA;RF9Trifluoroacetate;RF9 trifluoroacetate salt;1-Adamantanecarbonyl-Arg-Phe-NH2;2-Adamantanecarbonyl-Arg-Phe-NH2;2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE;1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt;L-Phenylalaninamide, N2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-
- CBNumber
- CB7847749
- Molecular Formula
- C26H38N6O3
- Formula Weight
- 482.62
- MOL File
- 876310-60-0.mol
2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- H2O: soluble20mg/mL
- pka
- 14.53±0.20(Predicted)
- form
- solid
- color
- White
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 3672
- Product name
- RF9
- Packaging
- 1
- Price
- $115
- Updated
- 2021/12/16
- Product number
- R990013
- Product name
- RF9
- Packaging
- 1mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 256448
- Product name
- RF9
- Packaging
- 1mg
- Price
- $353
- Updated
- 2021/12/16
- Product number
- INB0004650
- Product name
- RF9 TRIFLUOROACETATE SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.08
- Updated
- 2021/12/16
- Product number
- CS-7903
- Product name
- RF9
- Purity
- 98.66%
- Packaging
- 1mg
- Price
- $108
- Updated
- 2021/12/16
2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE Chemical Properties,Usage,Production
Uses
RF9 is an NPFF1 and NPFF2 receptor inhibitor as well as RFRP-3 antagonist.
Definition
ChEBI: RF9 is a dipeptide formed from L-arginine and L-phenylalaninamide residues in which a hydrogen attached to the nitrogen of the alpha-amino group of the arginine residue has been replaced by a 1-adamantanecarbonyl group. It has been reported to be a potent and selective antagonist of neuropeptide FF (NPFF) receptors, but more recently found to be an agonist at both NPFF1R and the kisspeptin receptor (KISS1R). It has a role as a neuropeptide FF receptor antagonist, a neuropeptide FF receptor agonist and a kisspeptin receptor agonist. It is functionally related to an Arg-Ala.
Biological Activity
ki: 58 nm for npff1; 75 nm for npff2rf 9 is a neuropeptide ff receptors antagonist.neuropeptide ff (npff) has been isolated originally from bovine brain through its cross-reaction with antibodies to the molluscan cardioexcitory peptide fmrf-nh2, which possesses the similar c-terminal sequence. recent studies shows that npff belongs to a neuropeptide family including two g protein-coupled receptors (npff1 and npff2) and two precursors (pro-npffa and pro-npffb). both in vitro and in vivo studies have indicated that npff involves in a variety of biological actions.
in vitro
rf9 was found as a potent and selective npff receptor antagonist. rf9 was shown to be able to selectively bind to recombinant npff1 or npff2 receptors expressed in cho or cos-1 cell and could also in vitro antagonize the agonism induced by npff and npvf in the functional assays [1].
in vivo
aminal in vivo study showed rf9 (30 nmol) injection failed to induce significant effect, but rf9 could completely antagonize the hypothermia of npff after cerebral administration in mice. additionally, rf9 (30 nmol) co-injected in the third ventricle reduced the hypothermia induced by morphine or nociceptin/orphanin [2].
storage
Store at -20°C
References
[1] fang q,wang yq,he f,guo j,guo j,chen q,wang r. inhibition of neuropeptide ff (npff)-induced hypothermia and anti-morphine analgesia by rf9, a new selective npff receptors antagonist. regul pept.2008 apr 10;147(1-3):45-51.
[2] wang yq,guo j,wang sb,fang q,he f,wang r. neuropeptide ff receptors antagonist, rf9, attenuates opioid-evoked hypothermia in mice. peptides.2008 jul;29(7):1183-90.
2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 17705183659
- Fax
- 84523390
- sales@njleonbiotech.com
- Country
- China
- ProdList
- 5501
- Advantage
- 55
- Tel
- 025-025-58361106-805-805 13082558573
- Fax
- 025-58361106-806
- liugang@njpeptide.com
- Country
- China
- ProdList
- 9980
- Advantage
- 55
- Tel
- 025-66113011 13155353615
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15394
- Advantage
- 58
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 7071
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 028-81700200 18108052721
- 2850505130@qq.com
- Country
- China
- ProdList
- 5173
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 19850819832
- 2173594524@qq.com
- Country
- China
- ProdList
- 2638
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 18115476705
- sales@tgpeptide.com
- Country
- China
- ProdList
- 3058
- Advantage
- 58
- Tel
- 0571-88211921 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 2891
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4494
- Advantage
- 58
- Tel
- 021-021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 31121
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ：2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 0571-88211921 15572296305
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5178
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6628
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- 15888826472@163.com
- Country
- China
- ProdList
- 2729
- Advantage
- 58
- Tel
- 19961912513
- sales@hongtide.com
- Country
- China
- ProdList
- 4604
- Advantage
- 58
- Tel
- 13770887460
- wenxi@jszkhy.com
- Country
- China
- ProdList
- 1352
- Advantage
- 58
- Tel
- 0512-51886999 17706251929
- office@combiosz.com
- Country
- China
- ProdList
- 2978
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 6830
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29979
- Advantage
- 58
- Tel
- 021-59555769 13524932310
- Fax
- 021-50342869
- 1405894150@qq.com
- Country
- China
- ProdList
- 8221
- Advantage
- 58
- Tel
- 13327808530
- 2670965693@qq.com
- Country
- China
- ProdList
- 2179
- Advantage
- 58
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 4904
- Advantage
- 58
- Tel
- 19135651983 19135651983
- 18611134419@163.com
- Country
- China
- ProdList
- 4416
- Advantage
- 58
- Tel
- 0571-8512-5372
- sales@bingochem.com
- Country
- China
- ProdList
- 21669
- Advantage
- 58
- Tel
- 400-6206333 18021050169
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- bptsales@163.com
- Country
- China
- ProdList
- 3851
- Advantage
- 58
- Tel
- 029-81148929 13186179623
- 1049@dideu.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- 18003437475
- rdname@qq.com
- Country
- CHINA
- ProdList
- 35705
- Advantage
- 58
- Tel
- +8619375158599
- info@molchanges.com
- Country
- China
- ProdList
- 5223
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10311
- Advantage
- 58
- Tel
- +8617531972939
- anna@api-made.com
- Country
- China
- ProdList
- 2943
- Advantage
- 58
- Tel
- +86-13347807150 +86-13347807150
- support@tgpeptide.com
- Country
- China
- ProdList
- 3279
- Advantage
- 58
- Tel
- +86-17367732028 +86-17367732028
- kathy@hbyinsheng.com
- Country
- China
- ProdList
- 3512
- Advantage
- 58
- Tel
- +8618108235634
- Cecilia@youngshechem.com
- Country
- China
- ProdList
- 2345
- Advantage
- 58
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 24727
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@neobioscience.com
- Country
- CHINA
- ProdList
- 6682
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6705
- Advantage
- 58