2-Picolinic acid
- Product Name
- 2-Picolinic acid
- CAS No.
- 98-98-6
- Chemical Name
- 2-Picolinic acid
- Synonyms
- PICOLINIC ACID;PYRIDINE-2-CARBOXYLIC ACID;2-PYRIDINECARBOXYLIC ACID;Pyridine-2-carboxylic;PCL 016;Picolonic acid;2-Carboxypyridine;ALPHA-PICOLINIC ACID;2-Pyridinecarboxylic;2-PicoL
- CBNumber
- CB8196640
- Molecular Formula
- C6H5NO2
- Formula Weight
- 123.11
- MOL File
- 98-98-6.mol
2-Picolinic acid Property
- Melting point:
- 139-142 °C (lit.)
- Boiling point:
- 229.19°C (rough estimate)
- Density
- 1.3147 (rough estimate)
- vapor pressure
- 0.028Pa at 25℃
- refractive index
- 1.5423 (estimate)
- Flash point:
- 139°(232°F)
- storage temp.
- Store below +30°C.
- solubility
- H2O: 50 mg/mL, clear
- pka
- 1.07(at 25℃)
- form
- Crystalline Powder
- color
- White to almost white
- PH
- 3.1 (50g/l, H2O, 20℃)
- Water Solubility
- 887 g/L (20 ºC)
- Merck
- 14,7403
- BRN
- 109595
- InChIKey
- SIOXPEMLGUPBBT-UHFFFAOYSA-N
- LogP
- 0.72
- CAS DataBase Reference
- 98-98-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Pyridinecarboxylic acid(98-98-6)
- EPA Substance Registry System
- 2-Pyridinecarboxylic acid (98-98-6)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36-36/37/38
- Safety Statements
- 26-36-33-24/25
- WGK Germany
- 3
- RTECS
- TJ7344000
- TSCA
- Yes
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P42800
- Product name
- 2-Picolinic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 5g
- Price
- $47.9
- Updated
- 2024/03/01
- Product number
- P42800
- Product name
- 2-Picolinic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 100g
- Price
- $78.5
- Updated
- 2024/03/01
- Product number
- 8.00735
- Product name
- 2-Pyridinecarboxylic acid
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $76.3
- Updated
- 2022/05/15
- Product number
- P0421
- Product name
- Pyridine-2-carboxylic Acid
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $22
- Updated
- 2024/03/01
- Product number
- P0421
- Product name
- Pyridine-2-carboxylic Acid
- Purity
- >99.0%(T)
- Packaging
- 100g
- Price
- $53
- Updated
- 2024/03/01
2-Picolinic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white to tan powder. easily soluble in glacial acetic acid, almost insoluble in ether, chloroform and carbon disulfide.
Uses
2-Picolinic acid is used as a chelate for alkaline earth metals. It is also used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.
Application
2-Picolinic acid is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.
Metal complexes of picolinic acid were prepared by the refluxion of metal salts and picolinic acid in ethanol taking 1:3 molar ratio for 6 hours. The solutions were concentrated and cooled, to crystallize out the complexes.The complexes were washed with ether to remove the excess ligand.
Definition
ChEBI: Picolinic acid is a pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan. It has a role as a MALDI matrix material and a human metabolite. It is a conjugate acid of a picolinate.
Synthesis
2-Picolinic acid synthesis: In a 500ml three-necked flask, add 100g of 2-cyanopyridine and 200g of deionized water, then start stirring, heat up to 50°C, add 128.2g of 30% sodium hydroxide to the flask, after adding, add Continue to heat up, react under reflux for 4 hours, then distill water, after 50 g of distilled water, cool the reaction solution to 20°C, add 30% hydrochloric acid, adjust the pH value of the reaction solution to 2.5, then turn on the steam to heat up the water and steam to the kettle When the temperature reaches 120°C, the reaction solution is evaporated to dryness, and the distilled water is completed. Then, 300 g of anhydrous alcohol is added dropwise to the flask to maintain the temperature of the reaction solution at 55°C. After cooling and crystallization, a solid was precipitated, filtered and dried to obtain 106.0 g of 2-picolinic acid with a yield of 89.6%.
Purification Methods
Crystallise the acid from water or *benzene. The picrate has m 185-187o (from MeOH). [Beilstein 22 H 33, 22 I 502, 22 II 30, 22 III/IV 303, 22/2 V 3.]
2-Picolinic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Picolinic acid manufacturers
- Product
- 2-Picolinic acid 98-98-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-25
- Product
- Picolinic acid 98-98-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500mt/year
- Release date
- 2021-07-27
- Product
- 2-Picolinic acid 98-98-6
- Price
- US $36.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-05-16