ChemicalBook > CAS DataBase List > 1-(4-BROMOBENZYL)INDOLE-2,3-DIONE

1-(4-BROMOBENZYL)INDOLE-2,3-DIONE

Product Name: 1-(4-BROMOBENZYL)INDOLE-2,3-DIONE
CAS No.: 79183-37-2
Chemical Name: 1-(4-BROMOBENZYL)INDOLE-2,3-DIONE
Synonyms: VU0119498;VU0119498 ，S0783;VU0119498, 10 mM in DMSO;1-(4-BROMOBENZYL)INDOLE-2,3-DIONE;1-(4-bromobenzyl)-1H-indole-2,3-dione;1-[(4-Bromophenyl)methyl]indole-2,3-dione;1H-Indole-2,3-dione, 1-[(4-bromophenyl)methyl]-;VU0119498, M1 muscarinic receptor agonist and pan mAChR M3, M5 PAM;antidiabetic,VU 0119498,Inhibitor,VU0119498,inhibit,VU-0119498,mAChR,pan,Muscarinic acetylcholine receptor
CBNumber: CB82463915
Molecular Formula: C15H10BrNO2
Formula Weight: 316.15
MOL File: 79183-37-2.mol

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1-(4-BROMOBENZYL)INDOLE-2,3-DIONE Property

Melting point:: 178-180 °C
Boiling point:: 469.2±47.0 °C(Predicted)
Density: 1.604±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: 50 mg/mL (158.15 mM)
form: A solid
pka: -2.61±0.20(Predicted)
color: Orange to red

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0064669
Product name: VU0119498
Packaging: 10mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0064669
Product name: VU0119498
Packaging: 50mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 5425CJ
Product name: 1-[(4-Bromophenyl)methyl]indole-2,3-dione
Packaging: 250mg
Price: $203
Updated: 2021/12/16

ChemScene

Product number: CS-0064669
Product name: VU0119498
Packaging: 25mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0064669
Product name: VU0119498
Packaging: 100mg
Price: $240
Updated: 2021/12/16

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1-(4-BROMOBENZYL)INDOLE-2,3-DIONE Chemical Properties,Usage,Production

Uses

VU0119498 is a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC50s of 6.04, 6.38, and 4.08 μM, respectively. VU0119498 has antidiabetic activity[1][2][3].

in vivo

VU0119498 (0.1-2 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in mice in a β-cell M3R-dependent fashion^[3].
VU0119498 (0.5 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in obese, glucose-intolerant mice^[3].

Animal Model:	Male WT mice (12 weeks)^[3]
Dosage:	0.1, 0.5, 2 mg/kg
Administration:	A single i.p.
Result:	Caused a significant improvement in glucose tolerance at the dose of 0.5 mg/kg. Significantly augmented GSIS at the dose of 0.5 mg/kg.

References

[1] Bridges TM, et, al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8. DOI:10.1021/jm900286j
[2] Bridges TM, et, al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5. DOI:10.1016/j.bmcl.2010.01.109
[3] Zhu L, et, al. Allosteric modulation of β-cell M 3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690. DOI:10.1073/pnas.1904943116

1-(4-BROMOBENZYL)INDOLE-2,3-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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79183-37-2, 1-(4-BROMOBENZYL)INDOLE-2,3-DIONERelated Search:

VU 0357017 hydrochloride 2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide VUF 10460 VUF 10166 N6022 VU 0364770 VU0134992(hydrochloride) VU6012962 VU0810464 VU6015929 VU0238441 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VUN65671 VU 0357121 VU6010608 VU 0364439 VU-29

1-(4-BROMOBENZYL)INDOLE-2,3-DIONE

VU0119498

1-(4-bromobenzyl)-1H-indole-2,3-dione

1H-Indole-2,3-dione, 1-[(4-bromophenyl)methyl]-

antidiabetic,VU 0119498,Inhibitor,VU0119498,inhibit,VU-0119498,mAChR,pan,Muscarinic acetylcholine receptor

VU0119498, M1 muscarinic receptor agonist and pan mAChR M3, M5 PAM

VU0119498, 10 mM in DMSO

1-[(4-Bromophenyl)methyl]indole-2,3-dione

VU0119498 ，S0783

79183-37-2