ChemicalBook > CAS DataBase List > BML-210

BML-210

Product Name
BML-210
CAS No.
537034-17-6
Chemical Name
BML-210
Synonyms
CS-2301;BML-210;CAY10433;BML210, >98%;BML-210, (BML210;BML-210(CAY10433);BML-210 >=98% (HPLC), powder;N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE;N1-(2-aminophenyl)-N8-phenyl-octanediamide;Octanediamide, N1-(2-aminophenyl)-N8-phenyl-
CBNumber
CB8254476
Molecular Formula
C20H25N3O2
Formula Weight
339.43
MOL File
537034-17-6.mol
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BML-210 Property

storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
color 
white to very faintly yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B8063
Product name
BML-210
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
B8063
Product name
BML-210
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$466
Updated
2024/03/01
Cayman Chemical
Product number
10005019
Product name
BML-210
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10005019
Product name
BML-210
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
10005019
Product name
BML-210
Purity
≥95%
Packaging
10mg
Price
$169
Updated
2024/03/01
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BML-210 Chemical Properties,Usage,Production

Description

Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation. BML-210 is a small molecule inhibitor of HDAC with an IC50 value of 30 μM when tested in HeLa cell nuclear extracts using 200 μM acetylated fluorometric substrate (substrate available in Cayman’s HDAC Activity and Inhibitor Screening Assay Kits - Item Nos. 10011563 and 10011564).

Uses

N1-(2-Aminophenyl)-N8-phenyloctanediamide is a histone deacetylase (HDAC) inhibitor, an anti-cancer target for breast cancer therapeutic intervention.

Definition

ChEBI: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and 1,2-diaminobenzene.

Biochem/physiol Actions

BML-210 is a synthetic benzamide and is a potential tumor inhibitor. It is used as a therapeutic agent to treat promyelocytic leukemia. In human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 modulates histone deacetylase and promotes apoptosis. BML-210 favors frataxin expression in neurodegenerative disease Friedreich′s ataxia (FRDA). It interacts with myocyte enhancer factor-2 (MEF2) via hydrogen-bonding and prevents histone deacetylase 4 (HDAC4) binding.

References

1) Savickiene, et al. (2006), The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines; Eur. J. Pharmacol. 549 9 2) Herman, et al. (2006), Histone deacetylase inhibitors reverse gene silencing in Friedreich’s ataxia; Nat. Chem. Biol. 10 551

BML-210 Preparation Products And Raw materials

Raw materials

Preparation Products

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BML-210 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
D&C Chemicals
Tel
+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
Country
China
ProdList
472
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862,442785678,326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
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View Lastest Price from BML-210 manufacturers

Career Henan Chemical Co
Product
BML-210 537034-17-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23
Career Henan Chemical Co
Product
BML-210 537034-17-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

537034-17-6, BML-210Related Search:


  • N-PHENYL-N'-(2-AMINOPHENYL)HEXAMETHYLENEDIAMIDE
  • N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE
  • BML-210
  • CAY10433
  • N1-(2-aminophenyl)-N8-phenyl-octanediamide
  • BML-210(CAY10433)
  • BML-210, (BML210
  • CS-2301
  • BML210; BML 210;CAY10433;CAY-10433;CAY 10433
  • BML210, >98%
  • Octanediamide, N1-(2-aminophenyl)-N8-phenyl-
  • BML-210 >=98% (HPLC), powder
  • Inhibitor,HDAC,BML210,BML-210,BML 210,Apoptosis,inhibit,Histone deacetylases
  • 537034-17-6