BML-210
- Product Name
- BML-210
- CAS No.
- 537034-17-6
- Chemical Name
- BML-210
- Synonyms
- CS-2301;BML-210;CAY10433;BML210, >98%;BML-210, (BML210;BML-210(CAY10433);BML-210 >=98% (HPLC), powder;N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE;N1-(2-aminophenyl)-N8-phenyl-octanediamide;Octanediamide, N1-(2-aminophenyl)-N8-phenyl-
- CBNumber
- CB8254476
- Molecular Formula
- C20H25N3O2
- Formula Weight
- 339.43
- MOL File
- 537034-17-6.mol
BML-210 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- powder
- color
- white to very faintly yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B8063
- Product name
- BML-210
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $147
- Updated
- 2024/03/01
- Product number
- B8063
- Product name
- BML-210
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $466
- Updated
- 2024/03/01
- Product number
- 10005019
- Product name
- BML-210
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 10005019
- Product name
- BML-210
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 10005019
- Product name
- BML-210
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
BML-210 Chemical Properties,Usage,Production
Description
Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation. BML-210 is a small molecule inhibitor of HDAC with an IC50 value of 30 μM when tested in HeLa cell nuclear extracts using 200 μM acetylated fluorometric substrate (substrate available in Cayman’s HDAC Activity and Inhibitor Screening Assay Kits -
Uses
N1-(2-Aminophenyl)-N8-phenyloctanediamide is a histone deacetylase (HDAC) inhibitor, an anti-cancer target for breast cancer therapeutic intervention.
Definition
ChEBI: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and 1,2-diaminobenzene.
Biochem/physiol Actions
BML-210 is a synthetic benzamide and is a potential tumor inhibitor. It is used as a therapeutic agent to treat promyelocytic leukemia. In human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 modulates histone deacetylase and promotes apoptosis. BML-210 favors frataxin expression in neurodegenerative disease Friedreich′s ataxia (FRDA). It interacts with myocyte enhancer factor-2 (MEF2) via hydrogen-bonding and prevents histone deacetylase 4 (HDAC4) binding.
References
1) Savickiene, et al. (2006), The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines; Eur. J. Pharmacol. 549 9 2) Herman, et al. (2006), Histone deacetylase inhibitors reverse gene silencing in Friedreich’s ataxia; Nat. Chem. Biol. 10 551
BML-210 Preparation Products And Raw materials
Raw materials
Preparation Products
BML-210 Suppliers
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- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
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- United States
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- 025-58849295 18951903616;
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- 025-68650336
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- China
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- Fax
- -
- sales@shjiyipharmatech.com
- Country
- China
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- Fax
- 50966098
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- 021-61415566 800-8193336
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- China
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- Fax
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- China
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- Tel
- 021-50908862，442785678，326799392 18721037013
- Fax
- 021-50908862
- siyansales@126.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
View Lastest Price from BML-210 manufacturers
- Product
- BML-210 537034-17-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23
- Product
- BML-210 537034-17-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-20