ChemicalBook > CAS DataBase List > BML-210

BML-210

Product Name
BML-210
CAS No.
537034-17-6
Chemical Name
BML-210
Synonyms
CS-2301;BML-210;CAY10433;BML210, >98%;BML-210, (BML210;BML-210(CAY10433);BML-210 >=98% (HPLC), powder;N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE;N1-(2-aminophenyl)-N8-phenyl-octanediamide;Octanediamide, N1-(2-aminophenyl)-N8-phenyl-
CBNumber
CB8254476
Molecular Formula
C20H25N3O2
Formula Weight
339.43
MOL File
537034-17-6.mol
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BML-210 Property

storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
color 
white to very faintly yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B8063
Product name
BML-210
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
B8063
Product name
BML-210
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$466
Updated
2024/03/01
Cayman Chemical
Product number
10005019
Product name
BML-210
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10005019
Product name
BML-210
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
10005019
Product name
BML-210
Purity
≥95%
Packaging
10mg
Price
$169
Updated
2024/03/01
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BML-210 Chemical Properties,Usage,Production

Description

Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation. BML-210 is a small molecule inhibitor of HDAC with an IC50 value of 30 μM when tested in HeLa cell nuclear extracts using 200 μM acetylated fluorometric substrate (substrate available in Cayman’s HDAC Activity and Inhibitor Screening Assay Kits - Item Nos. 10011563 and 10011564).

Uses

N1-(2-Aminophenyl)-N8-phenyloctanediamide is a histone deacetylase (HDAC) inhibitor, an anti-cancer target for breast cancer therapeutic intervention.

Definition

ChEBI: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and 1,2-diaminobenzene.

Biochem/physiol Actions

BML-210 is a synthetic benzamide and is a potential tumor inhibitor. It is used as a therapeutic agent to treat promyelocytic leukemia. In human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 modulates histone deacetylase and promotes apoptosis. BML-210 favors frataxin expression in neurodegenerative disease Friedreich′s ataxia (FRDA). It interacts with myocyte enhancer factor-2 (MEF2) via hydrogen-bonding and prevents histone deacetylase 4 (HDAC4) binding.

References

1) Savickiene, et al. (2006), The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines; Eur. J. Pharmacol. 549 9 2) Herman, et al. (2006), Histone deacetylase inhibitors reverse gene silencing in Friedreich’s ataxia; Nat. Chem. Biol. 10 551

BML-210 Preparation Products And Raw materials

Raw materials

Preparation Products

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BML-210 Suppliers

China 68 United States 13 Global 81
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from BML-210 manufacturers

Career Henan Chemical Co
Product
BML-210 537034-17-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23
Career Henan Chemical Co
Product
BML-210 537034-17-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

537034-17-6, BML-210Related Search:

Trichostatin C TRICHOSTATIN A Sodium Butyrate Suberohydroxamic acid 1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE APICIDIN CAY10603 OXAMFLATIN Tubacin Entinostat HC TOXIN M344 Parthenolide BML-210

  • N-PHENYL-N'-(2-AMINOPHENYL)HEXAMETHYLENEDIAMIDE
  • N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE
  • BML-210
  • CAY10433
  • N1-(2-aminophenyl)-N8-phenyl-octanediamide
  • BML-210(CAY10433)
  • BML-210, (BML210
  • CS-2301
  • BML210; BML 210;CAY10433;CAY-10433;CAY 10433
  • BML210, >98%
  • Octanediamide, N1-(2-aminophenyl)-N8-phenyl-
  • BML-210 >=98% (HPLC), powder
  • Inhibitor,HDAC,BML210,BML-210,BML 210,Apoptosis,inhibit,Histone deacetylases
  • 537034-17-6