BML-210

ChemicalBook > CAS DataBase List > BML-210

Product Name: BML-210
CAS No.: 537034-17-6
Chemical Name: BML-210
Synonyms: CS-2301;BML-210;CAY10433;BML210, >98%;BML-210, (BML210;BML-210(CAY10433);BML-210 >=98% (HPLC), powder;N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE;N1-(2-aminophenyl)-N8-phenyl-octanediamide;Octanediamide, N1-(2-aminophenyl)-N8-phenyl-
CBNumber: CB8254476
Molecular Formula: C20H25N3O2
Formula Weight: 339.43
MOL File: 537034-17-6.mol

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BML-210 Property

storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: powder
color: white to very faintly yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B8063
Product name: BML-210
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: B8063
Product name: BML-210
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $466
Updated: 2024/03/01

Cayman Chemical

Product number: 10005019
Product name: BML-210
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10005019
Product name: BML-210
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 10005019
Product name: BML-210
Purity: ≥95%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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BML-210 Chemical Properties,Usage,Production

Description

Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation. BML-210 is a small molecule inhibitor of HDAC with an IC₅₀ value of 30 μM when tested in HeLa cell nuclear extracts using 200 μM acetylated fluorometric substrate (substrate available in Cayman’s HDAC Activity and Inhibitor Screening Assay Kits - Item Nos. 10011563 and 10011564).

Uses

N1-(2-Aminophenyl)-N8-phenyloctanediamide is a histone deacetylase (HDAC) inhibitor, an anti-cancer target for breast cancer therapeutic intervention.

Definition

ChEBI: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and 1,2-diaminobenzene.

Biochem/physiol Actions

BML-210 is a synthetic benzamide and is a potential tumor inhibitor. It is used as a therapeutic agent to treat promyelocytic leukemia. In human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 modulates histone deacetylase and promotes apoptosis. BML-210 favors frataxin expression in neurodegenerative disease Friedreich′s ataxia (FRDA). It interacts with myocyte enhancer factor-2 (MEF2) via hydrogen-bonding and prevents histone deacetylase 4 (HDAC4) binding.

References

1) Savickiene, et al. (2006), The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines; Eur. J. Pharmacol. 549 9 2) Herman, et al. (2006), Histone deacetylase inhibitors reverse gene silencing in Friedreich’s ataxia; Nat. Chem. Biol. 10 551

BML-210 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BML-210 manufacturers

Career Henan Chemical Co

Product: BML-210 537034-17-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

Career Henan Chemical Co

Product: BML-210 537034-17-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

537034-17-6, BML-210Related Search:

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N-PHENYL-N'-(2-AMINOPHENYL)HEXAMETHYLENEDIAMIDE

N-(2-AMINOPHENYL)-N'-PHENYL-OCTANEDIAMIDE

BML-210

CAY10433

N1-(2-aminophenyl)-N8-phenyl-octanediamide

BML-210(CAY10433)

BML-210, (BML210

CS-2301

BML210; BML 210;CAY10433;CAY-10433;CAY 10433

BML210, >98%

Octanediamide, N1-(2-aminophenyl)-N8-phenyl-

BML-210 >=98% (HPLC), powder

Inhibitor,HDAC,BML210,BML-210,BML 210,Apoptosis,inhibit,Histone deacetylases

537034-17-6