1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
- Product Name
- 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
- CAS No.
- 145317-11-9
- Chemical Name
- 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
- Synonyms
- BIM X;BIM-X hydrochloride;Ro 31-8425 Ro 31-8425;Bisindoylmaleimide X HCl;BIM X;RO 31-8425RO 31-8425;Bisindoylmaleimide X hydrochloride ≥95%;Bisindoylmaleimide X (Ro 31-8425);Bisindolylmaleimide X hydrochloride, 10 mM in DMSO;BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE);Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor
- CBNumber
- CB82667395
- Molecular Formula
- C26H25ClN4O2
- Formula Weight
- 460.96
- MOL File
- 145317-11-9.mol
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO (up to 10 mg/ml)
- form
- Red solid.
- color
- Red
- biological source
- synthetic (organic)
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B3931
- Product name
- Bisindolylmaleimide X hydrochloride
- Purity
- ≥90%, solid
- Packaging
- 1MG
- Price
- $148
- Updated
- 2025/07/31
- Product number
- B3931
- Product name
- Bisindolylmaleimide X hydrochloride
- Purity
- ≥90%, solid
- Packaging
- 5MG
- Price
- $539
- Updated
- 2023/06/20
- Product number
- 17511
- Product name
- Bisindolylmaleimide X (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $60
- Updated
- 2024/03/01
- Product number
- 17511
- Product name
- Bisindolylmaleimide X (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- B448525
- Product name
- BisindolylmaleimideXHydrochloride
- Packaging
- 5mg
- Price
- $165
- Updated
- 2021/12/16
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Chemical Properties,Usage,Production
Description
Ro 31-8425 (145317-11-9) is a selective, reversible, ATP-competitive inhibitor of protein kinase C. Inhibits PKCα, β1, β2, γ and ε, IC50= 8, 8, 14,13 and 39 nM respectively.1? Extremely useful tool for probing PKC-dependent physiology2 or signaling pathways3. Increases MSC adhesion to an ICAM-1 coated substrate in vitro and enables targeted delivery of systematically administered MSCs to inflamed sites in vivo in a CD11a-dependent manner.4? Cell permeable.
Uses
Bisindolylmaleimide X hydrochloride is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide X and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure.
IC 50
PKC; CDK2: 200 nM (IC50)
References
[1] S E WILKINSON J S N P J Parker. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.[J]. Biochemical Journal, 1993, 294 ( Pt 2): 335-337. DOI:10.1042/bj2940335
[2] WENYAN NIU. PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells†[J]. Journal of Cellular Physiology, 2010, 226 1: 173-180. DOI:10.1002/jcp.22320
[3] JOSE M JIMENEZ-LOPEZ A I C. Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 312 3: 998-1006. DOI:10.1124/jpet.104.076737
[4] OREN LEVY. A small-molecule screen for enhanced homing of systemically infused cells.[J]. Cell reports, 2015, 10 8: 1261-1268. DOI:10.1016/j.celrep.2015.01.057
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Preparation Products And Raw materials
Raw materials
Preparation Products
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