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4-Amino-2-picoline

Product Name
4-Amino-2-picoline
CAS No.
18437-58-6
Chemical Name
4-Amino-2-picoline
Synonyms
AURORA 2465;4-Amino-2-methyL;AKOS BBS-00006740;4-AMINO-6-PICOLINE;4-AMINO-2-PICOLINE;2-Methyl-4-pyridinamine;4-AMino-2-Methylpyrdine;2-METHYLPYRIDIN-4-AMINE;4-Pyridinamine,2-methyl-;4-AMINO-2-METHYLPYRIDINE
CBNumber
CB8755539
Molecular Formula
C6H8N2
Formula Weight
108.14
MOL File
18437-58-6.mol
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4-Amino-2-picoline Property

Melting point:
93-97 °C
Boiling point:
143°C/9mmHg(lit.)
Density 
1.068±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in methanol.
pka
9?+-.0.30(Predicted)
form 
Powder
color 
Tan
CAS DataBase Reference
18437-58-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
22-37/38-41-36/37/38-20/21/22
Safety Statements 
26-36/39-36
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT, TOXIC
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
662712
Product name
4-Amino-2-methylpyridine
Purity
97%
Packaging
1g
Price
$177
Updated
2025/07/31
Sigma-Aldrich
Product number
662712
Product name
4-Amino-2-methylpyridine
Purity
97%
Packaging
250mg
Price
$82
Updated
2023/06/20
TCI Chemical
Product number
A2348
Product name
4-Amino-2-methylpyridine
Purity
>97.0%(GC)
Packaging
1g
Price
$39
Updated
2025/07/31
TRC
Product number
A617460
Product name
4-Amino-2-methylpyridine
Packaging
10g
Price
$70
Updated
2021/12/16
TRC
Product number
A617460
Product name
4-Amino-2-methylpyridine
Packaging
5g
Price
$60
Updated
2021/12/16
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4-Amino-2-picoline Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

4-Amino-2-methylpyridine is used to prepare 2-methyl-pyridin-4-ol; nitrate at 20°C.

Synthesis

5470-66-6

18437-58-6

General procedure for the synthesis of 2-methyl-4-aminopyridine from 2-methyl-4-nitropyridine-N-oxide: 2-methyl-4-nitropyridine-N-oxide (5 g, 32.4 mmol) and iron powder (18.1 g, 324 mmol) were mechanically stirred for 3 hours in acetic acid (300 mL) at 70 °C. After completion of the reaction, the mixture was cooled to room temperature and concentrated under vacuum. The pH of the residue was adjusted to greater than 10 with aqueous NaOH, taking care to use a minimum amount of water. The reaction mixture was transferred to a liquid-liquid extractor and continuously extracted with chloroform for 12 hours. The organic layer was separated and dried over anhydrous sodium sulfate and subsequently concentrated in vacuum to afford the target product 4-amino-2-methylpyridine (3.5 g, >99% yield).

References

[1] Patent: WO2004/14913, 2004, A2. Location in patent: Page 81
[2] Patent: EP1403252, 2004, A1. Location in patent: Page 8
[3] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 166
[4] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 292
[5] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 203

4-Amino-2-picoline Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate Ethanol Phosphorus oxitrichloride Chloroform 4-Nitro-2-picoline N-oxide Dichloromethane Acetic acid Iron Sulfuric acid

Preparation Products

4-AMINO-3-CHLORO-PYRIDINE-2-CARBOXYLIC ACID 4-Aminopyridine-2-carboxylic acid
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4-Amino-2-picoline Suppliers

Americas 1 Austria 1 Belgium 1 Canada 3 China 283 Europe 4 France 1 Germany 10 India 25 Japan 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 15 United States 47 Global 397
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
General Intermediates of Canada, Inc.
Tel
--
Fax
--
Email
info@generalintermediates.com
Country
Canada
ProdList
640
Advantage
38
AB Chemicals Inc.
Tel
--
Fax
--
Email
sales@abcheminc.com
Country
Canada
ProdList
1128
Advantage
47
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View Lastest Price from 4-Amino-2-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Amino-2-picoline 18437-58-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Amino-2-picoline 18437-58-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500KGS
Release date
2021-11-17
Watson Biotechnology Co.,Ltd
Product
4-Amino-2-methylpyridine 18437-58-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2024-08-15

18437-58-6, 4-Amino-2-picolineRelated Search:

4-Aminopyridine 4-Dimethylaminopyridine 6-Aminocaproic acid 4-Amino-2-methoxypyridine 4-Methylpyridine ALTRENOGEST 2-Picoline Glycine 3-Aminopyridine 3-Aminophenol 2,5-Dimethylpyridine 2-Chloro-5-chloromethylpyridine OMEGA-AMINO-B-PICOLINE Tris(hydroxymethyl)aminomethane 4-Chloro-2-picoline 2-Methyl-5-nitroimidazole 2-Methyl-4-nitropyridine 2-Methyl-5-nitropyridine

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  • 2-Methylpyridin-4-amine, 4-Amino-2-picoline
  • 4-Amino-2-methylpyridine 97%
  • 2-METHYL-4-AMINOPYRIDINE
  • 2-METHYLPYRIDIN-4-AMINE
  • 2-METHYL-PYRIDIN-4-YLAMINE
  • AKOS BBS-00006740
  • 4-AMINO-6-PICOLINE
  • 4-AMINO-2-PICOLINE
  • 4-Amino-2-methylpyridine≥ 98% (HPLC)
  • 4-Amino-2-methylpyridine &gt
  • 4-Amino-2-methyL
  • 4-Amino-2-picoline ISO 9001：2015 REACH
  • 18437-58-6
  • 18437-81-3
  • C6H8N2
  • Heterocyclic Building Blocks
  • Pyridines
  • Building Blocks
  • C6
  • VARIOUSAMINE
  • Amines
  • blocks
  • Pyridines
  • Pyridine
  • Amines and Anilines
  • Heterocycles
  • Aromatics
  • Intermediates
  • Pyridine Series