ChemicalBook > CAS DataBase List > 4-Amino-2-picoline
4-Amino-2-picoline
- Product Name
- 4-Amino-2-picoline
- CAS No.
- 18437-58-6
- Chemical Name
- 4-Amino-2-picoline
- Synonyms
- AURORA 2465;4-Amino-2-methyL;AKOS BBS-00006740;4-AMINO-6-PICOLINE;4-AMINO-2-PICOLINE;2-Methyl-4-pyridinamine;4-AMino-2-Methylpyrdine;2-METHYLPYRIDIN-4-AMINE;4-Pyridinamine,2-methyl-;4-AMINO-2-METHYLPYRIDINE
- CBNumber
- CB8755539
- Molecular Formula
- C6H8N2
- Formula Weight
- 108.14
- MOL File
- 18437-58-6.mol
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4-Amino-2-picoline Property
- Melting point:
- 93-97 °C
- Boiling point:
- 143°C/9mmHg(lit.)
- Density
- 1.068±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in methanol.
- pka
- 9?+-.0.30(Predicted)
- form
- Powder
- color
- Tan
- CAS DataBase Reference
- 18437-58-6(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 22-37/38-41-36/37/38-20/21/22
- Safety Statements
- 26-36/39-36
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT, TOXIC
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 662712
- Product name
- 4-Amino-2-methylpyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $177
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 662712
- Product name
- 4-Amino-2-methylpyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $82
- Updated
- 2023/06/20
TCI Chemical
- Product number
- A2348
- Product name
- 4-Amino-2-methylpyridine
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $39
- Updated
- 2025/07/31
TRC
- Product number
- A617460
- Product name
- 4-Amino-2-methylpyridine
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
TRC
- Product number
- A617460
- Product name
- 4-Amino-2-methylpyridine
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
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4-Amino-2-picoline Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
4-Amino-2-methylpyridine is used to prepare 2-methyl-pyridin-4-ol; nitrate at 20°C.
Synthesis
5470-66-6
18437-58-6
General procedure for the synthesis of 2-methyl-4-aminopyridine from 2-methyl-4-nitropyridine-N-oxide: 2-methyl-4-nitropyridine-N-oxide (5 g, 32.4 mmol) and iron powder (18.1 g, 324 mmol) were mechanically stirred for 3 hours in acetic acid (300 mL) at 70 °C. After completion of the reaction, the mixture was cooled to room temperature and concentrated under vacuum. The pH of the residue was adjusted to greater than 10 with aqueous NaOH, taking care to use a minimum amount of water. The reaction mixture was transferred to a liquid-liquid extractor and continuously extracted with chloroform for 12 hours. The organic layer was separated and dried over anhydrous sodium sulfate and subsequently concentrated in vacuum to afford the target product 4-amino-2-methylpyridine (3.5 g, >99% yield).
References
[1] Patent: WO2004/14913, 2004, A2. Location in patent: Page 81
[2] Patent: EP1403252, 2004, A1. Location in patent: Page 8
[3] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 166
[4] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 292
[5] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 203
4-Amino-2-picoline Preparation Products And Raw materials
Raw materials
Stannous chloride dihydrate
Ethanol
Phosphorus oxitrichloride
Chloroform
4-Nitro-2-picoline N-oxide
Dichloromethane
Acetic acid
Iron
Sulfuric acid
Preparation Products
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View Lastest Price from 4-Amino-2-picoline manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 4-Amino-2-picoline 18437-58-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-07
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- 4-Amino-2-picoline 18437-58-6
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500KGS
- Release date
- 2021-11-17
Watson Biotechnology Co.,Ltd
- Product
- 4-Amino-2-methylpyridine 18437-58-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2024-08-15
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