4-Bromo-3,5-difluoroaniline

Product Name: 4-Bromo-3,5-difluoroaniline
CAS No.: 203302-95-8
Chemical Name: 4-Bromo-3,5-difluoroaniline
Synonyms: BUTTPARK 35\03-50;4-BROMO-3,5-DIFLUOROANILINE;4-Bromo-3,5-difluoroaniline >4-Bromo-3,5-difluoroaniline 95%;4-bromo-3,5-difluoro-Benzenamine;Benzenamine, 4-bromo-3,5-difluoro-;4-Bromo-3,5-difluoroaniline ISO 9001：2015 REACH;4-BroMo-3,5-difluoroaniline 95%, 5-difluoroaniline 95%
CBNumber: CB8767273
Molecular Formula: C6H4BrF2N
Formula Weight: 208
MOL File: 203302-95-8.mol

More

Less

4-Bromo-3,5-difluoroaniline Property

Melting point:: 99-101°C
Boiling point:: 223.7±35.0 °C(Predicted)
Density: 1.788±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 1.86±0.10(Predicted)
color: White to Light gray to Light orange
InChI: InChI=1S/C6H4BrF2N/c7-6-4(8)1-3(10)2-5(6)9/h1-2H,10H2
InChIKey: DKKUSFDAHRASGO-UHFFFAOYSA-N
SMILES: C1(N)=CC(F)=C(Br)C(F)=C1
CAS DataBase Reference: 203302-95-8(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
RIDADR: UN2811
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 2921420090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B3416
Product name: 4-Bromo-3,5-difluoroaniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $62
Updated: 2025/07/31

TCI Chemical

Product number: B3416
Product name: 4-Bromo-3,5-difluoroaniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $247
Updated: 2025/07/31

TRC

Product number: B678980
Product name: 4-Bromo-3,5-difluoroaniline
Packaging: 5g
Price: $70
Updated: 2021/12/16

TRC

Product number: B678980
Product name: 4-Bromo-3,5-difluoroaniline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3630-B-43
Product name: 4-Bromo-3,5-difluoroaniline
Purity: 98%
Packaging: 25g
Price: $49
Updated: 2021/12/16

More

Less

4-Bromo-3,5-difluoroaniline Chemical Properties,Usage,Production

Chemical Properties

Pale yellow powder

Uses

4-Bromo-3,5-difluoroaniline is a useful reactant in organic synthesis.

Synthesis

372-39-4

203302-95-8

General procedure for the synthesis of 3,5-difluoro-4-bromoaniline from 3,5-difluoroaniline: 1. 3,5-difluoroaniline (10.0 g, 77.5 mmol) was dissolved in DMF (100 mL), then NBS (13.9 g, 78.0 mmol) was added in batches at room temperature. The reaction mixture was stirred overnight at room temperature and then diluted with Et2O and washed with brine. The organic phase was separated, dried over Na2SO4 and concentrated to give an oil. Purification by column chromatography afforded 4-bromo-3,5-difluoroaniline (i) (12.9 g, 80.2%). 2. A mixture of 4-bromo-3,5-difluoroaniline(i) (6.0 g, 28.8 mmol), ferrous sulfate (1.82 g), glycerol (8.6 mL), nitrobenzene (1.79 mL) and concentrated sulfuric acid (5.0 mL) was gently heated. After the first vigorous reaction, the mixture was boiled for 5 hours. Nitrobenzene was removed by vacuum distillation and the aqueous solution was acidified with glacial acetic acid to isolate a dark brown precipitate. Purification by rapid chromatography (silica gel, petroleum ether/ethyl acetate = 12/1) gave 6-bromo-5,7-difluoroquinoline (ii) as a white solid (3.5 g, 49.8%). 3. To a solution of 6-bromo-5,7-difluoroquinoline(ii) (250 g, 1.02 mol) in anhydrous THF (2200 mL) was added dropwise a hexane solution of n-BuLi (2.5 M, 408 mL, 1.02 mol) at -78 °C. The resulting mixture was stirred at -78 °C for another 30 min. Then, anhydrous THF (200 mL) solution of DMF (79 mL, 1.02 mol) was added while the temperature was kept below -70 °C and the mixture was stirred at the same temperature for 30 min. The reaction mixture was slowly warmed to room temperature and diluted with saturated aqueous NH4Cl solution (1000 mL) and water (800 mL). The mixture was extracted twice with ethyl acetate and the combined organic layers were washed with water and brine, dried over anhydrous sodium sulfate and concentrated to give a brown oil. Purification by silica gel column chromatography, eluting with petroleum ether and ethyl acetate (10:1), afforded 5,7-difluoroquinoline-6-carbaldehyde (Intermediate H) as a yellow solid (100 g, 50%). 1H NMR (DMSO, 300 MHz) δ (ppm): 10.38 (s, 1H), 9.10~9.12 (m, 1H), 8.62~8.66 (m, 1H), 7.68~7.78 (m, 2H).

References

[1] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 59-60
[2] Patent: WO2004/48314, 2004, A1. Location in patent: Page 31-32
[3] Patent: US2017/137385, 2017, A1. Location in patent: Paragraph 0243; 0244; 0245; 0246

4-Bromo-3,5-difluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Bromo-3,5-difluoroaniline Suppliers

Americas 1 China 158 Europe 1 France 2 Germany 4 India 7 Italy 1 Japan 1 The Netherlands 1 Ukraine 1 United Kingdom 19 United States 29 Global 225

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

Alfa Chemistry

Tel
Email: info@alfa-chemistry.com
Country: United States
ProdList: 2344
Advantage: 58

Aston Chemical

Tel: 13000000000
Email: sales@astonchem.com
Country: United States
ProdList: 1634
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

BromOrganics Corporation

Tel: --
Fax: --
Email: sales@bromorganics.com
Country: United States
ProdList: 1065
Advantage: 58

Brightek LLC

Tel: --
Fax: --
Country: United States
ProdList: 782
Advantage: 58

Combi-Blocks, Inc.

Tel: --
Fax: --
Email: les@combi-blocks.com
Country: United States
ProdList: 2555
Advantage: 58

SynQuest Laboratories, Inc.,

Tel: --
Fax: --
Country: United States
ProdList: 2301
Advantage: 58

Chemphtec Corporation

Tel: --
Fax: --
Email: fo@chemphtec.com
Country: United States
ProdList: 2181
Advantage: 58

eNovation Chemicals LLC

Tel: --
Fax: --
Email: ales@eNovationChem.com
Country: United States
ProdList: 1673
Advantage: 58

2A Biotech USA

Tel: --
Fax: --
Email: info@2abiotech.com
Country: United States
ProdList: 1785
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

INDOFINE Chemical Company, Inc.

Tel: --
Fax: --
Email: chemical@indofinechemical.com
Country: United States
ProdList: 6176
Advantage: 69

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

TimTec Corporation

Tel: --
Fax: --
Country: United States
ProdList: 1945
Advantage: 58

AcceleDev Chemical LLC

Tel: --
Fax: --
Email: info@acceledev.com
Country: United States
ProdList: 632
Advantage: 42

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

More

Less

View Lastest Price from 4-Bromo-3,5-difluoroaniline manufacturers

Career Henan Chemical Co

Product: 4-Bromo-3,5-difluoroaniline 203302-95-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

203302-95-8, 4-Bromo-3,5-difluoroanilineRelated Search:

4-Aminobenzotrifluoride 2-Aminobenzotrifluoride 4-Fluoroaniline 4-(Trifluoromethoxy)aniline 3-Bromoaniline 2,5-Difluoroaniline 4-Bromoaniline 2-Fluoroaniline 3,5-Difluoroaniline Ethyl bromodifluoroacetate Bromine 3-Bromo-4,5-difluoroaniline98%,3-Bromo-4,5-difluoroaniline 98%,3-BROMO-4,5-DIFLUOROANILINE 2-Bromo-4,6-difluoroaniline98%,2-Bromo-4,6-difluoroaniline 98%,2-BROMO-4,6-DIFLUOROANILINE,2-Bromo-4,6-difluoroaniline, 99+%,6-BROMO-2,4-DIFLUOROANILINE 4-BROMO-2,6-DIFLUOROANILINE,4-BROMO-2,6-DIFLUOROANILINE 99% 3-BROMO-4,6-DIFLUOROANILINE,5-BROMO-2,4-DIFLUOROANILINE 2-Bromo-3,4-Difluoroaniline 3-Bromo-2,6-difluoroaniline 4-Bromo-2,5-difluoroaniline98%,4-Bromo-2,5-difluoroaniline 98%,4-BROMO-2,5-DIFLUOROANILINE

4-BROMO-3,5-DIFLUOROANILINE

BUTTPARK 35\03-50

4-bromo-3,5-difluoro-Benzenamine

4-Bromo-3,5-difluoroaniline 95%

4-BroMo-3,5-difluoroaniline 95%, 5-difluoroaniline 95%

Benzenamine, 4-bromo-3,5-difluoro-

4-Bromo-3,5-difluoroaniline &gt

4-Bromo-3,5-difluoroaniline ISO 9001：2015 REACH

203302-95-8

203303-95-8

Anilines, Aromatic Amines and Nitro Compounds

Aniline