2-Chloro-3-iodopyridine
- Product Name
- 2-Chloro-3-iodopyridine
- CAS No.
- 78607-36-0
- Chemical Name
- 2-Chloro-3-iodopyridine
- Synonyms
- 2-Chloro-3-iodopy;BUTTPARK 34\07-77;oro-3-iodopyridine;2-Chloro-3-iodopyrid;2-CHORO-3-IODOPYRIDINE;3-iodo-2-chloropyridine;2-chloro-3-indopyridine;2-CHLORO-3-IODOPYRIDINE;Pyridine, 2-chloro-3-iodo-;2-Chloro-3-iodopyridine 97%
- CBNumber
- CB9149496
- Molecular Formula
- C5H3ClIN
- Formula Weight
- 239.44
- MOL File
- 78607-36-0.mol
2-Chloro-3-iodopyridine Property
- Melting point:
- 90-95 °C
- Boiling point:
- 261.2±20.0 °C(Predicted)
- Density
- 2.052±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate
- pka
- -0.70±0.10(Predicted)
- form
- Crystalline Powder
- color
- Cream yellow to salmon
- Sensitive
- Light Sensitive
- BRN
- 4243304
- InChI
- InChI=1S/C5H3ClIN/c6-5-4(7)2-1-3-8-5/h1-3H
- InChIKey
- OHWSWGXNZDSHLM-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1I
- CAS DataBase Reference
- 78607-36-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-20/22-41-22
- Safety Statements
- 36/37/39-26-22-36-39-37
- WGK Germany
- 3
- Hazard Note
- Irritant/Light Sensitive
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 716030
- Product name
- 2-Chloro-3-iodopyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $70.5
- Updated
- 2023/06/20
- Product number
- C2193
- Product name
- 2-Chloro-3-iodopyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- C2193
- Product name
- 2-Chloro-3-iodopyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- C367260
- Product name
- 2-Chloro-3-iodopyridine
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- C5012-24
- Product name
- 2-Chloro-3-iodopyridine
- Packaging
- 500mg
- Price
- $347
- Updated
- 2021/12/16
2-Chloro-3-iodopyridine Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
2-Chloro-3-iodopyridine is a compound useful in organic synthesis.
Uses
2-Chloro-3-iodopyridine (cas# 78607-36-0) is a compound useful in organic synthesis.
Synthesis
109-09-1
78607-36-0
General procedure for the synthesis of 2-chloro-3-iodopyridine from 2-chloropyridine: 2,2,6,6-tetramethylpiperidine (17 mL, 14 g, 0.1 mol) and 2-chloropyridine (9.5 mL, 11.5 g, 0.1 mol) were sequentially added to a hexane solution of 1.6 M n-butyllithium (62.5 mL, 0.1 mol) at -78 °C with a solvent of 150 mL of tetrahydrofuran. After maintaining the reaction temperature at -78 °C with stirring for 2 h, a tetrahydrofuran solution (50 mL) of iodine (25.5 g, 0.1 mol) was added dropwise to the reaction mixture and stirring was continued for 30 min. Subsequently, the reaction mixture was partitioned between water (100 mL) and ether (3 x 50 mL). The organic layers were combined, washed with saturated aqueous sodium thiosulfate solution (2 x 50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated in vacuum to give the crude product. The crude product was purified by fast chromatography (eluent: heptane/ethyl acetate, 90/10) to give a yellow solid product in 72% yield (17.3 g). The structure of the product was analyzed by 1H NMR (CDCl3): δ 8.38 (dd, J = 4.6/1.7 Hz, 1H), 8.16 (dd, J = 8.0/0.16 Hz, 1H), 6.96 (dd, J = 8.0/4.6 Hz, 1H); 13C NMR (CDCl3): δ 154.5, 148.9, 148.8, 123.2 , 94.9; MS (EI) m/z 240 (M + 1) confirmed.
References
[1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1397 - 1401
[3] Patent: WO2004/52880, 2004, A1. Location in patent: Page 29-30
[4] Tetrahedron Letters, 1994, vol. 35, # 35, p. 6489 - 6492
[5] Organic letters, 2002, vol. 4, # 13, p. 2201 - 2203
2-Chloro-3-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-3-iodopyridine Suppliers
- Tel
- --
- Fax
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- info@dottikon.com
- Country
- Switzerland
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View Lastest Price from 2-Chloro-3-iodopyridine manufacturers
- Product
- 2-Chloro-3-iodopyridine 78607-36-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.83%
- Supply Ability
- 1000kg
- Release date
- 2025-10-29
- Product
- 2-Chloro-3-iodopyridine 78607-36-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-01
- Product
- 2-Chloro-3-iodopyridine 78607-36-0
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31