ChemicalBook > CAS DataBase List > 2’-O-Methyl-rA(N-Bz)phosphoramidite

2’-O-Methyl-rA(N-Bz)phosphoramidite

Product Name
2’-O-Methyl-rA(N-Bz)phosphoramidite
CAS No.
110782-31-5
Chemical Name
2’-O-Methyl-rA(N-Bz)phosphoramidite
Synonyms
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Ac-dA Phosphoramidite;2’-OMe -dA(Bz) Amidite;-2-((bis(4-methoxyphenyl);2'OMe-A CE PhosphoraMidite;N6-Bz-5'-O-DMT-2'-OMe-A-CE;2'-OMe-Bz-A Phosphoramidite;Bz-2'-OMe-rA Phosphoramidite;2'-OMe-A(Bz) Phosphoramidite;2'-OMe-A(Bz) Phosphoramidite
CBNumber
CB91871624
Molecular Formula
C48H54N7O8P
Formula Weight
887.96
MOL File
110782-31-5.mol
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2’-O-Methyl-rA(N-Bz)phosphoramidite Property

Melting point:
93-95°C
storage temp. 
Sealed in dry,2-8°C
solubility 
Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
7.87±0.43(Predicted)
color 
white to off-white
InChI
InChI=1/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/s3
InChIKey
AZCGOTUYEPXHMJ-DCATYJMPNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,49,r|
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A211180
Product name
DMT-2′O-Methyl-rA(bz) Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
1G
Price
$98.7
Updated
2024/03/01
Sigma-Aldrich
Product number
A211150
Product name
DMT-2′O-Methyl-rA(bz) Phosphoramidite
Purity
configured for (?KTA? and OligoPilot?), configured for ABI
Packaging
2g
Price
$181
Updated
2024/03/01
Sigma-Aldrich
Product number
A211100
Product name
DMT-2′O-Methyl-rA(bz) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
100g
Price
$6540
Updated
2024/03/01
Sigma-Aldrich
Product number
A211100
Product name
DMT-2′O-Methyl-rA(bz) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
500g
Price
$32550
Updated
2024/03/01
Sigma-Aldrich
Product number
A211180
Product name
DMT-2′O-Methyl-rA(bz) Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
0.5g
Price
$92.7
Updated
2024/03/01
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2’-O-Methyl-rA(N-Bz)phosphoramidite Chemical Properties,Usage,Production

Chemical Properties

White or off-white power

Uses

(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA.

General Description

Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotectionschemes that are based on the application of aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analog that is characterized by theexceptional hybridization properties that it imparts with complimentary DNA or RNA, as well as increased stability against enzymatic degradationcompared to natural nucleic acids.The unique combination of properties of 2′O-Methyl RNA had foundwidespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

2’-O-Methyl-rA(N-Bz)phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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2’-O-Methyl-rA(N-Bz)phosphoramidite Suppliers

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View Lastest Price from 2’-O-Methyl-rA(N-Bz)phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
N6-Bz-5'-O-DMT-2'-OMe-A-CE 110782-31-5
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
SHANGHAI NOVRIBO BIOTECH
Product
2'-OMe-Bz-A CE Phosphoramidite 110782-31-5
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21
Henan Aochuang Chemical Co.,Ltd.
Product
2’-O-Methyl-rA(N-Bz)phosphoramidite 110782-31-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-23

110782-31-5, 2’-O-Methyl-rA(N-Bz)phosphoramiditeRelated Search:

DMT-dG(dmf) Phosphoramidite DMT-2′O-Methyl-rC(ac) Phosphoramidite 2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite 2'-O-(2-Methoxyethyl)-5-methyluridine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-(2-Methoxyethyl)cytidine 2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite 2'-O-(2-Methoxyethyl)guanosine 2'-O-Methyladenosine

  • 2’-O-Methyl-rA(N-Bz)phosphoramidite
  • N-blocked-5'-O-DMT-2'-O-Me CED adenosine phosphoramidite
  • 5'-O-DMT-2'-O-Me-rA(N-Bz)-3'-CEDPA
  • N-Benzoyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methyladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 2'-OMe-Bz-A Phosphoramidite
  • Ac-dA Phosphoramidite
  • 5'-O-DMT-2'-O-Me-A(bz) phosphoramidite
  • 2'OMe-A CE PhosphoraMidite
  • 5'-DiMethoxytrityl-N-benzoyl-Adenosine,2'-O-Methyl, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite
  • N6-Benzoyl-5'-O-DMT-2'-O-methyl-D-adenosine 3'-CE phosphoramidite
  • DMT-2′O-Methyl-rA(bz) Phosphoramidite
  • 2'-O-Methyl-N6-Benzoyl-5'-O-DMT-Adenosine-3'-CE-Phosphoramidite
  • 5'-DMT-2'-OMe-rA(N-Bz) Phosphoramidite
  • (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
  • -2-((bis(4-methoxyphenyl)
  • -4-methoxytetrahydrofuran-3-yl (2-cyanoethyl)
  • -5-(6-Benzamido-9H-purin-9-yl)
  • N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl adenosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphoramidite
  • N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine 3'-CE phosphoramidite
  • N-[9-(5-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-4-{[(2-CYANOETHOXY)(DIISOPROPYLAMINO)PHOSPHANY
  • 2'-OMe-Bz-rA -CE Phosphoramidite
  • Bz-2'-OMe-rA Phosphoramidite
  • N6-benzoyl-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Adenosine-3'-CE-Phosphoramidite
  • 2'-O-methyladenosine-ce phosphoramidite for abi
  • Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 2'-OMe-A(Bz) Phosphoramidite
  • 5'-O-DMT-2'-OMe-Bz-A-CE-Phosphoramidite
  • DMT-2'-OME-dA(Bz)-CE-Phosphoramidite
  • DMT-2-OMe-A (Bz) Phosphoramidite
  • 5'-DMTr-2'-O-Me-N6Bz-3'-O-CEP-ADENOSINE
  • N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]purin-6-yl]benzamide
  • 5'-O-DMT-N6-Benzoyl-2'-O-methyladenosine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-OMe-Benzoyl-Adenosine-CE Phosphoramidite
  • DMT-2-O-ME-A-CE Phosphoramidite
  • N6-Bz-5'-O-DMT-2'-OMe-A-CE
  • DMT-2’-OMe-A(Bz)-CE Phosphoramidite
  • 5'-O-DMT-2'-OMe-N6-Benzoyl -Adenosine-3’-Cyanoethyl Phosphoramidite
  • 2'-OMe-N-Bz Adenosine Amidite
  • DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
  • 2’-OMe -dA(Bz) Amidite
  • 5'-ODMT-2'-OMe-N-Bz Adenosine-3'-OCEPA
  • 2’-O-Methyl-rA(N-Bz)phosphoramidite
  • 2'-OMe-Bz-A Phosphoramidite
  • DMT-2'-O-Me-A(Bz)-CE Phosphoramidite
  • DMT-2'-O-methyl-rA(Bz) Phosphoramidite
  • 5'-O-DMT-2'-OMe-Benzoyl-Adenosine-CE Phosphoramidite
  • 2'-OMe-A(Bz) Phosphoramidite
  • 2'-OMe-A(Bz)-CE-Phosphoramidite
  • 2'-OMe-Bz-A CE Phosphoramidite
  • N6-Bz-2'-O-Me-5'-O-DMT-A-3'-CE-Phosphoramidite
  • 2'-OMe-rA(Bz)Phosphoramidite
  • N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine 3'-CE phosphoramidite
  • N-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-methyladenosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-O-DMT-2'-OMe-N6-Benzoyl -Adenosine-3’-Cyanoethyl Phosphoramidite
  • 2'-OMe-N-Bz Adenosine Amidite
  • 110782-31-5
  • Amidite