2’-O-Methyl-rA(N-Bz)phosphoramidite
- Product Name
- 2’-O-Methyl-rA(N-Bz)phosphoramidite
- CAS No.
- 110782-31-5
- Chemical Name
- 2’-O-Methyl-rA(N-Bz)phosphoramidite
- Synonyms
- (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Ac-dA Phosphoramidite;2’-OMe -dA(Bz) Amidite;-2-((bis(4-methoxyphenyl);2'OMe-A CE PhosphoraMidite;N6-Bz-5'-O-DMT-2'-OMe-A-CE;2'-OMe-Bz-A Phosphoramidite;Bz-2'-OMe-rA Phosphoramidite;2'-OMe-A(Bz) Phosphoramidite;2'-OMe-A(Bz) Phosphoramidite
- CBNumber
- CB91871624
- Molecular Formula
- C48H54N7O8P
- Formula Weight
- 887.96
- MOL File
- 110782-31-5.mol
2’-O-Methyl-rA(N-Bz)phosphoramidite Property
- Melting point:
- 93-95°C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly)
- form
- powder
- pka
- 7.87±0.43(Predicted)
- color
- white to off-white
- InChI
- InChI=1/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/s3
- InChIKey
- AZCGOTUYEPXHMJ-DCATYJMPNA-N
- SMILES
- O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,49,r|
Safety
- WGK Germany
- 3
- HS Code
- 29349990
N-Bromosuccinimide Price
- Product number
- A211180
- Product name
- DMT-2′O-Methyl-rA(bz) Phosphoramidite
- Purity
- configured for PerkinElmer, configured for Polygen
- Packaging
- 1G
- Price
- $98.7
- Updated
- 2024/03/01
- Product number
- A211150
- Product name
- DMT-2′O-Methyl-rA(bz) Phosphoramidite
- Purity
- configured for (?KTA? and OligoPilot?), configured for ABI
- Packaging
- 2g
- Price
- $181
- Updated
- 2024/03/01
- Product number
- A211100
- Product name
- DMT-2′O-Methyl-rA(bz) Phosphoramidite
- Purity
- ≥99% (31P-NMR)
- Packaging
- 100g
- Price
- $6540
- Updated
- 2024/03/01
- Product number
- A211100
- Product name
- DMT-2′O-Methyl-rA(bz) Phosphoramidite
- Purity
- ≥99% (31P-NMR)
- Packaging
- 500g
- Price
- $32550
- Updated
- 2024/03/01
- Product number
- A211180
- Product name
- DMT-2′O-Methyl-rA(bz) Phosphoramidite
- Purity
- configured for PerkinElmer, configured for Polygen
- Packaging
- 0.5g
- Price
- $92.7
- Updated
- 2024/03/01
2’-O-Methyl-rA(N-Bz)phosphoramidite Chemical Properties,Usage,Production
Chemical Properties
White or off-white power
Uses
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA.
General Description
Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotectionschemes that are based on the application of aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analog that is characterized by theexceptional hybridization properties that it imparts with complimentary DNA or RNA, as well as increased stability against enzymatic degradationcompared to natural nucleic acids.The unique combination of properties of 2′O-Methyl RNA had foundwidespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules
2’-O-Methyl-rA(N-Bz)phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
2’-O-Methyl-rA(N-Bz)phosphoramidite Suppliers
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View Lastest Price from 2’-O-Methyl-rA(N-Bz)phosphoramidite manufacturers
- Product
- N6-Bz-5'-O-DMT-2'-OMe-A-CE 110782-31-5
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2023-03-09
- Product
- 2'-OMe-Bz-A CE Phosphoramidite 110782-31-5
- Price
- US $100.00/kg
- Min. Order
- 0.009999999776482582kg
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2023-03-21
- Product
- 2’-O-Methyl-rA(N-Bz)phosphoramidite 110782-31-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-23