ChemicalBook > CAS DataBase List > DMT-2μ-O-Me-rG(ib) amidite

DMT-2μ-O-Me-rG(ib) amidite

Product Name
DMT-2μ-O-Me-rG(ib) amidite
CAS No.
251647-55-9
Chemical Name
DMT-2μ-O-Me-rG(ib) amidite
Synonyms
DMT-2'-O-MOE-G(iBu)-CE;2’-MOE-dG(iBu) Amidite;DMT-2'-O-MOE-G(iBu)-CEP;DMT-2'-O-MOE-G(iBu)-CEP;DMT-2μ-O-Me-rG(ib) amidite;N2-iBu-5'-O-DMT-2'-O-MOE-G-CE;2'-O-MOE-ibu-G Phosphoramidite;2'-MOE-N-iBu Guanosine Amidite;2'-MOE-N-iBu Guanosine Amidite;2'-MOE-iBu-G CE Phosphoramidite
CBNumber
CB92092206
Molecular Formula
C47H60N7O10P
Formula Weight
913.99
MOL File
251647-55-9.mol
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DMT-2μ-O-Me-rG(ib) amidite Property

storage temp. 
4°C, protect from light
solubility 
DMSO : 250 mg/mL (273.53 mM; Need ultrasonic)
form 
Powder
pka
9.16±0.20(Predicted)
color 
White to Off-white
InChI
InChI=1/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(60-27-26-57-7)40(64-65(62-25-13-24-48)54(31(3)4)32(5)6)38(63-45)28-61-47(33-14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10-12,14-23,29-32,38,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,65?/s3
InChIKey
LADCDGNEBIQAAU-KEFUZROQNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,44,50,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J65100
Product name
5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-methylguanosine-3'-(2-cyanoethyl diisopropylphosphoramidite)
Purity
98%
Packaging
1g
Price
$65.65
Updated
2024/03/01
TRC
Product number
D494268
Product name
5''-O-DMT-N2-isobutyryl-2''-O-(2-methoxyethyl)-guanosine3''-CEphosphoramidite
Packaging
500mg
Price
$330
Updated
2021/12/16
Biosynth Carbosynth
Product number
PD63448
Product name
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
Packaging
2g
Price
$500
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
O108456
Product name
5?-O-DMT-N2-isobutyryl-2?-O-(2-methoxyethyl)-guanosine3?-CEphosphoramidite
Packaging
1g
Price
$675
Updated
2021/12/16
Biosynth Carbosynth
Product number
PD63448
Product name
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
Packaging
250mg
Price
$90
Updated
2021/12/16
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DMT-2μ-O-Me-rG(ib) amidite Chemical Properties,Usage,Production

Description

Nucleoside phosphoramidites are used in the synthesis of oligonucleotides. Using a chemical approach allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Enzymatic synthesis proceeds in a 5’ to 3’ direction, however the chemical synthesis is usually performed in the opposite direction. 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite, also known as DMT-2μ-O-Me-rG(ib) amidite, is a modified guanosine with a 2’-O-(2-methoxyethyl) group, these have been used in the synthesis of oligonucleotides as antisense drugs.

Uses

5''-O-DMT-N2-isobutyryl-2''-O-(2-methoxyethyl)-guanosine 3''-CE phosphoramidite (CAS# 251647-55-9) is a nucleotide, and a derivative of guanosine, and is used in the stereochemical sythesis of phosphorothioate oligonucleotides.

storage

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

DMT-2μ-O-Me-rG(ib) amidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-2μ-O-Me-rG(ib) amidite Suppliers

China 111 India 2 Switzerland 1 United Kingdom 2 United States 4 Global 120
Hefei Huana Biomedical Technology Co.,Ltd
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View Lastest Price from DMT-2μ-O-Me-rG(ib) amidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
N2-iBu-5'-O-DMT-2'-O-MOE-G-CE 251647-55-9
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
SHANGHAI NOVRIBO BIOTECH
Product
2'-MOE-iBu-G CE Phosphoramidite 251647-55-9
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-20

251647-55-9, DMT-2μ-O-Me-rG(ib) amiditeRelated Search:

2'-O-Methylcytidine 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite 2'-O-(2-Methoxyethyl)-5-methyluridine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine 2'-O-(2-Methoxyethyl)cytidine 2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite 2'-O-(2-Methoxyethyl)guanosine

  • DMT-2μ-O-Me-rG(ib) amidite
  • 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite
  • Guanosine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-(2-Methoxyethyl)-N-(2-Methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite]
  • 2'-MOE-G(iBu)-3'-phosphoramidite
  • 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-methylguanosine-3'-(2-cyanoethyl diisopropylphosphoramidite)
  • 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
  • 2'-O-MOE-G(iBu)-CE Phosphoramidite
  • GUANOSINE, 5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-O-(2-METHOXYETHYL)-N-(2-METHYL-1-OXOPROPYL)-, 3'-[2-CYANOETHYL BIS(1-METHYLETHYL)PHOSPHORAMIDITE] (9CI)
  • 2'-O-MOE-ibu-G Phosphoramidite
  • DMT-2'-O-MOE-G(iBu)-CEP
  • DMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite
  • N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O- methoxyethyl-guanosine-3'-cyanoethyl Phosphoramidite
  • Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 5’-O-(4,4’-Dimethoxy-trityl)-N2-iso-butyroyl-2’-O-(2-methoxyethyl)guanosine-3’-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphoramidite
  • 5'-O-DMT-N2-isobutyryl-2'-O-?methoxyethylguanosine 3'-CE phosphoramidite
  • N2-isobutyryl-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
  • 2'-O-MOE-rG(ibu) Phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-N2-isobutyryl- guanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5'-O-DMT-2’-MOE-N2-iBu-Guanosine-CE-Phosphoramidite
  • DMT-2′O-MOE-rG(ib) Phosphoramidite
  • 2’-MOE-G(iBu)-3’-phospho ramidite 5’-O-(4,4’-Dimethoxy-trityl)-N2-iso-butyroyl-2’-O-(2-methoxyethyl)guanosine-3’-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphoramidite
  • 5'-O-DMT-2'-MOE-N2-Isobutyryl-Guanosine-CE Phosphoramidite
  • 5’-O-DMTr-N2-iBu-2’-O-MOE-guanosine-3’-CED phosphoramidite
  • N2-iBu-5'-O-DMT-2'-O-MOE-G-CE
  • 2'-MOE-iBu-G CE Phosphoramidite
  • 5'-O-DMT-2'-O-MOE- N2-Isobutyryl- Guanosine -3’-Cyanoethyl Phosphoramidite
  • DMT-2'-O-MOE-G(iBu)-CE-PhosphoramiditeN2-isobutyryl-5'-O-(4,4'-dimethoxytri-tyl)-2'-O-methoxyethyl-guanosine-3'-cya-noethyl Phosphoramidite
  • 2'-MOE-N-iBu Guanosine Amidite
  • DMT-2'-O-MOE-G(iBu)-CE
  • [5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N6-benzoyladenosin-3'-O-yl]-2-cyanoethyl-N,N-diisopropylphosphoramidite
  • DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite
  • 2’-MOE-dG(iBu) Amidite
  • Guanosine, 5-o-bis(4-methoxyphenyl)phenylmethyl-2-o-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3-2-cyanoethyl bis(1-
  • 5’-O-(4, 4’-Dimethoxytrityl)-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-ODMT-2'-OMOE-N-iBu Guanosine-3'-OCEPA
  • DMT-2'-O-MOE-G(iBu)-CE Phosphoramidite
  • 2’-MOE-G(iBu)-3’-phosphoramidite
  • 5'-O-DMT-2'-MOE-N2-Isobutyryl-Guanosine-CE Phosphoramidite
  • 2'-MOE-iBu-G CE Phosphoramidite
  • 2'-O-MOE-G(iBu)-CE-Phosphoramidite
  • 5’-O-(4, 4’-Dimethoxytrityl)-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • [5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N6-benzoyladenosin-3'-O-yl]-2-cyanoethyl-N,N-diisopropylphosphoramidite
  • N2-iBu-2'-O-MOE-5'-O-DMT-G-3'-CE-Phosphoramidite
  • N-(9-[(2R,4R,5R)-5-[(bis(4-methoxyphenyl)(phenyl)methoxy)methyl]-4-{[(bis(propan-2-yl)amino)(2-cyanoethoxy)phosphanyl]oxy}-3-(2-methoxyethoxy)oxolan-2-yl]-6-oxo-6,9-dihydro-5H-purin-2-yl)-2-methylpropanamide
  • 2'-O-MOE-rG(ibu)Phosphoramidite
  • DMT-2'-O-MOE-G(iBu)-CEP
  • DMT-2'O-MOE-rG(ib) Phosphoramidite
  • N2-isobutyryl-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-O-MOE- N2-Isobutyryl- Guanosine -3’-Cyanoethyl Phosphoramidite
  • 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
  • 2'-MOE-N-iBu Guanosine Amidite
  • 251647-55-9
  • C47H60N7O10P
  • RNA Amidites
  • Sigma-Proligo
  • 2-Methyl RNA STD Amidites
  • Amidite