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5-Chloro-2-methoxybenzoic acid

Product Name
5-Chloro-2-methoxybenzoic acid
CAS No.
3438-16-2
Chemical Name
5-Chloro-2-methoxybenzoic acid
Synonyms
Glyburide IMP;Compound Fr12564;RARECHEM AL BO 0576;5-CHLORO-O-ANISIC ACID;5-CHLORO-2-ANISIC ACID;Glyburide IMP Impurity;2-Carboxy-4-chloroanisole;5-Chloro-2-methoxybenzoic;5-Chloro-o-anisic acid,99%;5-chloro-2-methoxybenzoate
CBNumber
CB9424205
Molecular Formula
C8H7ClO3
Formula Weight
186.59
MOL File
3438-16-2.mol
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5-Chloro-2-methoxybenzoic acid Property

Melting point:
98-100 °C (lit.)
Boiling point:
150-152C
Density 
1,259g/cm
refractive index 
1,544-1546
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol
form 
Crystalline Powder
pka
3.72±0.10(Predicted)
color 
White to off-white
InChI
InChI=1S/C8H7ClO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4H,1H3,(H,10,11)
InChIKey
HULDRQRKKXRXBI-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC(Cl)=CC=C1OC
LogP
2.368 (est)
CAS DataBase Reference
3438-16-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
292494
Product name
5-Chloro-2-methoxybenzoic acid
Purity
99%
Packaging
25g
Price
$38.64
Updated
2025/07/31
TCI Chemical
Product number
C1539
Product name
5-Chloro-2-methoxybenzoic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$93
Updated
2025/07/31
TRC
Product number
C367910
Product name
5-Chloro-2-methoxybenzoic Acid
Packaging
25g
Price
$50
Updated
2021/12/16
AK Scientific
Product number
D882
Product name
5-Chloro-2-methoxybenzoic Acid
Packaging
25g
Price
$27
Updated
2021/12/16
Matrix Scientific
Product number
075578
Product name
5-Chloro-2-methoxybenzoic acid
Purity
95+%
Packaging
10g
Price
$36
Updated
2021/12/16
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5-Chloro-2-methoxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

5-Chloro-2-methoxybenzoic acid has been used in the synthesis of 5-chloro-2-methoxybenzoates of La(III), Ga(III) and Lu(III).

General Description

Complexes of 4-chloro-2-methoxybenzoic acid anion with Mn2+, Co2+, Ni2+, Cu2+ and Zn2+ have been investigated.

Synthesis

33924-48-0

3438-16-2

General procedure for the synthesis of 5-chloro-2-methoxybenzoic acid from methyl 5-chloro-2-methoxybenzoate: to a 1 M aqueous sodium hydroxide solution (60 mL, 0.06 mol) was added a solution of methyl 5-chloro-2-methoxybenzoate (2.0 g, 0.01 mol) [Alfa Aesar] in ethanol (60 mL). The reaction mixture was stirred at room temperature for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until completion of the reaction. Subsequently, the reaction mixture was concentrated under reduced pressure to remove ethanol and the residue was separated by extraction with ethyl acetate. The aqueous phase was cooled in an ice bath and the pH was adjusted with concentrated aqueous hydrochloric acid to 2. After continued stirring in an ice bath for 1 h, the precipitated solid was collected by filtration, washed with water and dried in air to afford 1.4 g (74.9% yield) of the target product, 5-chloro-2-methoxybenzoic acid, as a white solid. Mass spectrum (MS): m/z 185.1 (MH+). 1H NMR (500 MHz, DMSO-d6): δ 3.818 (s, 3H), 7.162 (d, 1H), 7.551 (dd, 1H), 7.607 (d, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 21, p. 6819 - 6829
[2] Patent: WO2014/165816, 2014, A1. Location in patent: Page/Page column 98-99
[3] Journal of the American Chemical Society, 1988, vol. 110, p. 7178
[4] Patent: US4895860, 1990, A

5-Chloro-2-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

5-Chloro-2-hydroxybenzoic acid Dimethyl sulfate

Preparation Products

4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE 5-CHLORO-2-METHOXYBENZOYL CHLORIDE 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
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5-Chloro-2-methoxybenzoic acid Suppliers

Americas 1 Belgium 2 Canada 1 China 173 Europe 3 Germany 3 India 11 Japan 2 Switzerland 2 Ukraine 2 United Kingdom 14 United States 37 Global 251
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View Lastest Price from 5-Chloro-2-methoxybenzoic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-Chloro-2-methoxybenzoic acid 3438-16-2
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-25
Career Henan Chemical Co
Product
5-Chloro-2-methoxybenzoic acid 3438-16-2
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-20

3438-16-2, 5-Chloro-2-methoxybenzoic acidRelated Search:

EPA Anisole 3-Chloroperoxybenzoic acid (Trifluoromethoxy)benzene p-Anisidine 4-Methoxybenzoic acid 4-Methoxybenzylchloride 5-Chloro-2-methylbenzoic acid 3-Methoxybenzoic acid 2-Methoxybenzoic acid 2,6-Dimethoxybenzoic acid 3,4-Dimethoxybenzoic acid 4-(Chloromethyl)benzoic acid Ascoric Acid Difluorochloromethane 3-CHLORO-2,6-DIMETHOXY-5-NITROBENZOIC ACID N-ACETYL-4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID, METHYL ESTER,4-ACETAMIDO-5-CHLORO-2-METHOXYBENZOIC ACID METHYL ESTER 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID

  • 2-Carboxy-4-chloroanisole
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  • 5-Chloro-2-methoxybenzoicacid,98%
  • 5-Chloro-2-methoxybenzoicacid,99%
  • 5-chloro-2-methoxybenzoic acid (intermediate of glibenclamide)
  • 5-Chloro-2-methoxybenzoic acid 97%
  • 5-CHLORO-2-METHOXYBENZOIC ACID / 5-CHLORO-O-ANISIC ACID
  • 5-chloro-2-methoxybenzoate
  • 5-Chloro-2-methoxybenzoicAcid&gt
  • Benzoic acid, 5-chloro-2-methoxy-
  • 5-Chloro-2-methoxybenzoic acid (Glibenclamide Impurity)
  • 5-Chloro-2-methoxybenzoic
  • Compound Fr12564
  • Glibenclamide impurity 9(5-Chloro-2-methoxybenzoic acid)
  • Glyburide IMP Impurity
  • 3438-16-2
  • 5438-16-2
  • Organic Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Building Blocks
  • Carbonyl Compounds
  • Carboxylic Acids
  • C8
  • API Intermediate
  • FINE Chemical & INTERMEDIATES
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Organic acids
  • (intermediate of glibenclamide)
  • Miscellaneous
  • Acids & Esters
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Chlorine Compounds