ChemicalBook > CAS DataBase List > (S)-1-Boc-3-methylpiperazine

(S)-1-Boc-3-methylpiperazine

Product Name
(S)-1-Boc-3-methylpiperazine
CAS No.
147081-29-6
Chemical Name
(S)-1-Boc-3-methylpiperazine
Synonyms
tert-butyl (S)-3-methylpiperazine-1-carboxylate;(S)-1-BOC-3-METHYLPIPERAZINE;(S)-TERT-BUTYL 3-METHYLPIPERAZINE-1-CARBOXYLATE;(S)-4-Boc-2-methylpiperazine;4-HYDROXY-7-METHOXYQUINOLINE-2-CARBOXYLIC ACID;4-Hydroxy-7-methoxy-2-quinolinecarboxylic acid;CPD2809-SM;(3S)-3-MethyL;(S)-4-N-BOC-2-METHYL;Sotorasib Impurity 2
CBNumber
CB9458934
Molecular Formula
C10H20N2O2
Formula Weight
200.28
MOL File
147081-29-6.mol
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(S)-1-Boc-3-methylpiperazine Property

Melting point:
40-45 °C
alpha 
-16 º (c=1 in dioxane)
Boiling point:
268.7±15.0 °C(Predicted)
Density 
0.997±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
form 
Crystalline Powder
pka
8.52±0.40(Predicted)
color 
White to yellow
optical activity
[α]/D -16±2°, c = 1 in dioxane
Sensitive 
Air Sensitive
InChI
InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1
InChIKey
FMLPQHJYUZTHQS-QMMMGPOBSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN[C@@H](C)C1
CAS DataBase Reference
147081-29-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41-34
Safety Statements 
26-39-45-36/37/39
RIDADR 
3259
WGK Germany 
3
F 
10-34
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
63207
Product name
(S)-1-Boc-3-methylpiperazine
Purity
≥98%
Packaging
1g
Price
$21.9
Updated
2024/03/01
Sigma-Aldrich
Product number
63207
Product name
(S)-1-Boc-3-methylpiperazine
Purity
≥98%
Packaging
5G
Price
$65.4
Updated
2024/03/01
Alfa Aesar
Product number
H27534
Product name
(S)-(-)-1-Boc-3-methylpiperazine, 98%
Packaging
1g
Price
$64.65
Updated
2024/03/01
Alfa Aesar
Product number
H27534
Product name
(S)-(-)-1-Boc-3-methylpiperazine, 98%
Packaging
5g
Price
$256
Updated
2024/03/01
TRC
Product number
B656830
Product name
(S)-4-Boc-2-methylpiperazine
Packaging
25g
Price
$305
Updated
2021/12/16
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(S)-1-Boc-3-methylpiperazine Chemical Properties,Usage,Production

Description

(S)-1-Boc-3-methylpiperazine is a hydrophobic compound that is structurally modified from the tetracyclic family of drugs. It has been shown to inhibit tumor cell growth by binding to the oncogene, KRASG12C, and downregulating its expression. This compound also inhibits cancer cell growth through the inhibition of the PI3K/AKT signaling pathway. The pharmacological effects of (S)-1-Boc-3-methylpiperazine are dependent on its ability to bind with high affinity to KRASG12C and inhibit its activity.

Chemical Properties

colorless to yellow liquid

Uses

Laboratory chemicals, Manufacture of substances.

Uses

Reactant involved in the synthesis of biologically activy molecules including:

  • CCR5 antagonists with anti-HIV-1 activity
  • Opioid receptor antagonists
  • Human growth hormone secretagogue receptor antagonists for treatment of obesity
  • Fatty acid oxidation inhibitors

Uses

(S)-4-Boc-2-methylpiperazine ((S)-1-Boc-3-methylpiperazine) is a reagent used in the synthesis of benzamide peptidomimetic as non-ATP competitive inihbitors.

(S)-1-Boc-3-methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-Boc-3-methylpiperazine Suppliers

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View Lastest Price from (S)-1-Boc-3-methylpiperazine manufacturers

Shanghai UCHEM Inc.
Product
(S)-4-N-Boc-2-methylpiperazine 147081-29-6
Price
US $37.00-788.00/g
Min. Order
10g
Purity
0.99
Supply Ability
25kg
Release date
2023-12-15
AstaTech(Chengdu) Biopharmaceutical Corp.
Product
(S)-4-N-Boc-2-methylpiperazine 147081-29-6
Price
US $0.00-0.00/KG
Min. Order
0.5KG
Purity
99.0%GC
Supply Ability
1-5tons/year
Release date
2022-01-07
Henan Fengda Chemical Co., Ltd
Product
(S)-1-Boc-3-methylpiperazine 147081-29-6
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-15

147081-29-6, (S)-1-Boc-3-methylpiperazineRelated Search:

(S)-1-Boc-3-benzylpiperazine (S)-tert-butyl 3-formylpiperidine-1-carboxylate (3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester (S)-1-N-Boc-3-ethylpiperazine (S)-1-BOC-3-PROPYLPIPERAZINE R-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid N-4-Boc-2-piperazinecarboxylic acid (S)-1-Boc-3-methylpiperazine 1-BOC-3,5-DIMETHYL-PIPERAZINE t-Butyl(2R,5S)-2,5-dimethylpiperazine-1-carboxylate (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (R)-1-BOC-3-(Hydroxymethyl)piperazine (S)-2-tert-Butylcarboxamide-4-tert-butoxycarbonyl piperazine (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE (S)-1-N-Boc-2-methylpiperazine 4-N-Boc-2-Methyl-piperazine 1-Boc-2-Methylpiperazine (R)-1-Boc-3-methylpiperazine

  • TERT-BUTYL (S)-3-METHYL-1-PIPERAZINECARBOXYLATE
  • (S)-TERT-BUTYL 3-METHYLPIPERAZINE-1-CARBOXYLATE
  • (S)-N4-BOC-2-METHYLPIPERAZINE
  • (S)-1-TERT-BUTOXYCARBONYL-3-METHYLPIPERAZINE
  • (S)-1-N-BOC-3-METHYLPIPERAZINE
  • (S)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • (S)-1-BOC-3-METHYLPIPERAZINE
  • (S)-4-N-BOC-2-METHYL PIPERAZINE
  • 1-PIPERAZINECARBOXYLIC ACID, 3-METHYL-, 1,1-DIMETHYLETHYL ESTER, (3S)-
  • tert-butyl (S)-3-methylpiperazine-1-carboxylate
  • (S)-1-Boc-3-methylpiperazine≥ 99% (HPLC, Chiral purity)
  • 4-BOC-2-(S)-METHYL-PIPERAZINE
  • (3S)-1-BOC-3-METHYLPIPERAZINE
  • (S)-3-Methyl-1-Boc-piperazine
  • (S)-4-N-Boc-2-MethylPiperazinee
  • 4-HYDROXY-7-METHOXYQUINOLINE-2-CARBOXYLIC ACID
  • (S)-4-N-Boc-2-methylpiperazine (S)-4-N-Boc-2-methyl piperazine
  • (S)-2-METHYL-1-BOC-PIPERAZINE
  • (S)-4-Boc-2-methylpiperazine
  • (S)-2-Methylpiperazine, N4-BOC protected
  • (S)-3-Methylpiperazine, N1-BOC protected
  • 4-Hydroxy-7-methoxy-2-quinolinecarboxylic acid
  • (S)-4-N-BOC-2-METHYL
  • (s)-3-methyl-piperazine-1-carboxylic acid tert-butyl
  • (S)-4-N-BOC-2-Methylpiperazine-HCl
  • (3S)-3-Methylpiperazine-1-carboxylic acid tert-butyl ester
  • tert-Butyl (3S)-3-methylpiperazine-1-carboxylate, (3S)-1-(tert-Butoxycarbonyl)-3-methylpiperazine
  • (<I>S</I>)<WBR>-<WBR>1-<WBR>Boc-<WBR>3-<WBR>Methylpiperazine
  • (S)-1-Boc-3-Methylpiperazine, 98%+
  • (3S)-3-Methylpiperazine, N1-BOC protected
  • Chemdraw8(S)-3-Methyl-piperazine-1-carboxylic acid tert-butyl ester
  • CPD2809-SM
  • (3S)-3-MethyL
  • (S)-4-N-Boc-2-methylpiperazine ISO 9001：2015 REACH
  • 1-Piperazinecarboxylic acid, 3-methyl-, 1,1-dimethylethyl ester, (3S)- (9CI, ACI)
  • 3-methyl-1-Piperazinecarboxylic acid 1,1-dimethylethyl ester (3S)- (9CI ACI)
  • 3-Methyl-1-piperazinecarboxylic acid tert-butyl ester (3S)-
  • Sotorasib Impurity 2
  • 147081-29-6
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines
  • Piperazines
  • pharmacetical
  • Piperazine series
  • Quinoline series
  • Piperaizine
  • 147081-29-6