2-Bromo-5-fluoropyridine
- Product Name
- 2-Bromo-5-fluoropyridine
- CAS No.
- 41404-58-4
- Chemical Name
- 2-Bromo-5-fluoropyridine
- Synonyms
- 5-FLUOROPYRIDINE-2-BORONIC ACID;EOS-60511;2-bromo-5-fluoropyr;2-bromo-5-fluoropyridin;2-BoMo-5-fluoropyridine;2-BroMo-5-floropyridine;5-Fluoro-2-broMopyridine;2-BROMO-5-FLUOROPYRIDINE;3-Fluoro-6-bromopyridine;2--5- fluoropyridinebroMide
- CBNumber
- CB9683345
- Molecular Formula
- C5H3BrFN
- Formula Weight
- 175.99
- MOL File
- 41404-58-4.mol
2-Bromo-5-fluoropyridine Property
- Melting point:
- 30-31 °C (lit.)
- Boiling point:
- 80-83 °C/44 mmHg (lit.)
- Density
- 1.707±0.06 g/cm3(Predicted)
- refractive index
- 1.5396
- Flash point:
- 167 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Liquid
- pka
- -1.63±0.10(Predicted)
- color
- Colorless to slightly yellow
- BRN
- 1561456
- InChI
- InChI=1S/C5H3BrFN/c6-5-2-1-4(7)3-8-5/h1-3H
- InChIKey
- UODINHBLNPPDPD-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C(F)C=C1
- CAS DataBase Reference
- 41404-58-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn,F
- Risk Statements
- 36/37/38-20/21/22-10
- Safety Statements
- 26-36-16
- RIDADR
- 2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 595675
- Product name
- 2-Bromo-5-fluoropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $83.3
- Updated
- 2025/07/31
- Product number
- 595675
- Product name
- 2-Bromo-5-fluoropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/06/20
- Product number
- B2799
- Product name
- 2-Bromo-5-fluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- B2799
- Product name
- 2-Bromo-5-fluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $176
- Updated
- 2025/07/31
- Product number
- F588545
- Product name
- 3-Fluoro-6-bromopyridine
- Packaging
- 10g
- Price
- $195
- Updated
- 2021/12/16
2-Bromo-5-fluoropyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
2-Bromo-5-fluoropyridine can be used in the synthesis of the following:
- 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
- 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid
Uses
2-Bromo-5-fluoropyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.
Synthesis
21717-96-4
41404-58-4
Example C Synthesis of 2-bromo-5-fluoropyridine: 2-Amino-5-fluoropyridine (6.5 g, 58 mmol) was added in batches to 48% hydrobromic acid (28.8 mL, 296 mmol) cooled to 0-5 °C. A solution formed from bromine (8.9 mL, 174 mmol) and sodium nitrite (10 g, 145 mmol) dissolved in 20 mL of water was added slowly and dropwise at 0-5 °C (note: nitrogen release). The reaction mixture was stirred for 1 hour and then quenched with concentrated hydrochloric acid. A 32% sodium hydroxide solution (50.5 mL, 0.55 mol) was then added. The reaction mixture was continued to be stirred for 20 minutes at room temperature and then extracted three times with ether. The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure at 30 °C and 500 mbar (note: the product is volatile). The crude product was purified by rapid chromatography on silica gel with an elution gradient of dichloromethane/pentane (0:100 → 50:50). The final product was 2-bromo-5-fluoropyridine (6.7 g, 66% yield) in light yellow solid form.
References
[1] Patent: US2007/78155, 2007, A1. Location in patent: Page/Page column 29
[2] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0268
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 19, p. 5349 - 5352
2-Bromo-5-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-5-fluoropyridine Suppliers
- Tel
- --
- Fax
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- sales@riccichimica.com
- Country
- Italy
- ProdList
- 2146
- Advantage
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View Lastest Price from 2-Bromo-5-fluoropyridine manufacturers
- Product
- 2-Bromo-5-fluoropyridine 41404-58-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-20
- Product
- 2-Bromo-5-fluoropyridine 41404-58-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2-Bromo-5-fluoropyridine 41404-58-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12