1-Boc-3-hydroxymethyl-piperazine

Product Name: 1-Boc-3-hydroxymethyl-piperazine
CAS No.: 301673-16-5
Chemical Name: 1-Boc-3-hydroxymethyl-piperazine
Synonyms: tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;1-Boc-3-hydroxymethyl-piperazine;4-N-BOC-2-HYDROXYMETHYLPIPERAZINE;4-N-Bo;1-BOC-3-hydroxymethypiperazine;N-BOC-3-HYDROXYMETHYLPIPERAZINE;4-Boc-2-hydroxymethyl-piperazine;1-N-BOC-3-HYDROXYMETHYLPIPERAZINE;1-N-Boc-3-hydroxymethylpiperazine 98%;4-N-BOC-2-HYDROXYMETHYLPIPERAZINE -HCl
CBNumber: CB9726620
Molecular Formula: C10H20N2O3
Formula Weight: 216.28
MOL File: 301673-16-5.mol

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1-Boc-3-hydroxymethyl-piperazine Property

Melting point:: 93.0 to 97.0 °C
Boiling point:: 322.9±22.0 °C(Predicted)
Density: 1.085±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 14.97±0.10(Predicted)
color: White to Almost white
CAS DataBase Reference: 301673-16-5(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 2939800000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4716
Product name: 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $147
Updated: 2024/03/01

TCI Chemical

Product number: B4716
Product name: 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $635
Updated: 2023/06/20

TRC

Product number: B656643
Product name: 4-N-Boc-2-HydroxymethylpiperazineHydrochloride
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H51-1-72
Product name: 3-(Hydroxymethyl)piperazine, N1-Boc protected
Packaging: 1g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139852
Product name: tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate
Packaging: 1g
Price: $100
Updated: 2021/12/16

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1-Boc-3-hydroxymethyl-piperazine Chemical Properties,Usage,Production

Uses

1-Boc-3-Hydroxymethylpiperazine is an organic compound commonly used as an organic synthesis intermediate and pharmaceutical intermediate.

Synthesis

143540-05-0

301673-16-5

General procedure for the synthesis of 1-BOC-3-hydroxymethylpiperazine from 1,4-bis(Boc)-2-piperazinemethanol: To a solution of di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (4.00 g, 12.6 mmol) in ethanol (110 ml) was added sodium hydroxide (1.99 g, 49.8 mmol), and the mixture was heated under reflux conditions for 16 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was poured into water and the mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the target product 1-BOC-3-hydroxymethylpiperazine (2.71 g, 99.6% yield) as a solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 1.46 (9H, s), 2.12 (1H, br s), 2.64-3.01 (6H, br s), 3.47-3.53 (1H, m), 3.62-3.67 (1H, m), 3.89 (2H, br s).

References

[1] Patent: US2009/318412, 2009, A1. Location in patent: Page/Page column 34-35
[2] Patent: EP1338595, 2003, A2

1-Boc-3-hydroxymethyl-piperazine Preparation Products And Raw materials

Raw materials

Methanesulfonic anhydride Ethanol Potassium hydroxide 2-Pyrazinecarboxylic acid Calcium chloride Di-tert-butyl dicarbonate Potassium carbonate N,N-Diisopropylethylamine Sodium borohydride Lithium hydroxide Palladium 1,4-Dioxane Tetrahydrofuran 1,2-Dichloroethane Lithium Aluminum Hydride N,N-Dimethylacrylamide Dichloromethane Iodomethane PIPERAZINE-2-CARBOXYLIC ACID

Preparation Products

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View Lastest Price from 1-Boc-3-hydroxymethyl-piperazine manufacturers

Career Henan Chemical Co

Product: 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 301673-16-5
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-08

Career Henan Chemical Co

Product: 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 301673-16-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg，5kg，100kg
Release date: 2019-07-10

301673-16-5, 1-Boc-3-hydroxymethyl-piperazineRelated Search:

1-Boc-3-hydroxymethylpyrrolidine tert-butyl 3-(cyanoMethyl)piperidine-1-carboxylate 1-Boc-3-(Aminomethyl)azetidine (R)-1-BOC-3-(Hydroxymethyl)piperazine (S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester N-4-Boc-2-piperazinecarboxylic acid METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester 4-Boc-1-Fmoc-2-piperazinecarboxylic acid METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE (S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (R)-1-N-Boc-2-(hydroxymethyl)piperazine (S)-1-Boc-2-Hydroxymethyl-piperazine 1-N-Boc-2-(hydroxymethyl)piperazine

2-(HYDROXYMETHYL)-4-N-TERT-BUTOXYCARBONYL-PIPERAZINE

4-N-BOC-2-HYDROXYMETHYLPIPERAZINE

3-(HYDROXYMETHYL)-1-PIPERAZINE CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate

REF DUPL: 4-N-Boc-2-hydroxymethylpiperazine

4-Boc-2-hydroxymethyl-piperazine

1-BOC-3-hydroxymethypiperazine

1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester

3-Hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester ,97%

4-N-Bo

3-(Hydroxymethyl)piperazine, N1-BOC protected

tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine

4-N-BOC-2-HYDROXYMETHYLPIPERAZINE -HCl

1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine

1-(<i>tert</i>-Butoxycarbonyl)-3-(hydroxymethyl)piperazine

3-(Hydroxymethyl)-1-piperazinecarboxylic acid tert-butyl ester

1-Boc-3-hydroxymethyl-piperazine

N-BOC-3-HYDROXYMETHYLPIPERAZINE

1-N-BOC-3-HYDROXYMETHYLPIPERAZINE

(RS)-1-Boc-3-(hydroxyMethyl)-piperazine

3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID

tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylat

3-(Hydroxymethyl)piperazine, N1-BOC protected 97%

1-N-Boc-3-hydroxymethylpiperazine 98%

4-N-Boc-2-Hydroxymethylpiperazine Hydrochloride

1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester (9CI, ACI)

3-(hydroxymethyl)-1-Piperazinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI)

301673-16-5

pharmacetical

Piperaizine