Antibiotics
The first discovered antibiotic is penicillin. It was developed during World War II, due to the demand for effective anti-infective agent. In fact, people had realized the effects of these substances at as early as 1870s when people had observed the antagonistic phenomena between microorganisms. However, it was not until 1942 when S. A. Waksman observed these activities that people began to adopt the term of antibiotic. Although in 1928, A. Fleming had discovered the penicillin, however, people didn’t realize the importance of it due to that people hadn’t yet confirmed that this kind of natural-derived anti-microbial agents is capable of taking effect against systemic infection in humans and animals. It was not until the war pressure stimulated the research to combat infectious diseases agent, H. W. Florey and his colleagues E. B. Chain had extracted the refined products of penicillin and successfully demonstrated the effectiveness of penicillin treatment. In 1943, Waxman found a second antibiotic - streptomycin, and then proceeded to observe the antimicrobial effects of isolated bacitracin, neomycin, polymyxin, chloramphenicol, chlortetracycline, oxytetracycline and some other antibiotics, the importance of all antibiotics has shown up. With the success of the antibiotics in the chemical treatment, people have also further found that they also had wide applications in plant protection, animal husbandry, food preservation and other aspects.
Antibiotics generally refer to a class of substances produced during the life process of bacteria, fungi and other microbes with anti-pathogen properties. It is also important drugs for controlling the human and livestock diseases, anti-tumor as well as treatment of plant pest diseases. Antibiotic is a kind of secondary metabolites of microorganisms with small amount and low concentrations usage being able inhibit and kill another kind of microorganism. There are also some antibiotics having anti-tumor or other kinds of effect. Since the application of penicillin in medical treatment in the beginning of 1940, it had discovered and invented of several thousands of species of antibiotics, however there is no more than 100 kinds having been used in clinical application. These antibiotics are extracted from a microbial culture medium or manufactured through semi-synthesis or synthesis. Antibiotics, according to their origin and effect, are generally divided into penicillins, cephalosporins, aminoglycosides, tetracyclines, chloramphenicol, and macrolide, anti-fungal and anti-tumor. There are divided to broad spectrum and narrow spectrum based on the antimicrobial spectrum range.
The antibacterial mechanism and the role of various antibiotics also vary. For example, penicillin and bacitracin can hinder the bacterial cell wall synthesis; peptide antibiotics can destroy the bacterial plasma membrane; chloramphenicol and streptomycin can interfere with the protein synthesis or nucleic acid synthesis. Some antibiotics have small spectrum; for example, penicillin is only effective against gram-positive bacteria, and thus being called narrow spectrum antibiotics. Some antibiotics have broader spectrum for example tetracycline has inhibitory effect on most bacteria and is called broad-spectrum antibiotics.
There are about 100 kinds of antibiotics that have been get applied. For example, penicillin, streptomycin, and gentamicin have been widely used for medical treatment. In agriculture kasugamycin and Jinggangmycin have been widely used in the prevention and treatment of rice germs. Blasticidin has been used for the control of rice blast; GA is used for promoting the growth of plants and so on. However, the use of antibiotics be according to the condition used and should be avoided of using indiscriminately. Some antibiotics can produce some side effects for example continuous application of streptomycin and gentamicin can cause deafness while overdose of chloramphenicol can cause leukopenia. Some people are allergic to certain antibiotics with fatal effect in serious conditions. Therefore, “skin test” is needed for some antibiotics (such as penicillin) before use.
Rational application of antibiotics is the key issue during antibiotic application. Blindly misuse of antibiotics, especially long-term use of broad-spectrum antibiotics, will not only lead to resistant strains, and many antibiotics have side effects that can’t be ignored. They can even cause severe consequence of “secondary infection” due to the destruction of the body's normal flora. Therefore, we must strictly apply them in accordance with the prescription.
Agricultural Antibiotics: Since in 1950s when people had found that blasticidin S is effective in treating rice blast, it has developed into a fairly large class of antibiotics to date. There are a lot of antibiotics of anti-bacterial and anti-fungal for treating crop diseases such as kasugamycin (kasugamycin), Jinggangmycin (i.e. validamycin), polyoxin and actidione and so on. Some pesticides such as aphid-killing agents such as tetranactin and piercicidin have excellent control effect on some crop pest diseases. Some antibiotics can also significantly promote the growth of plants such as GA (gibberellin) and so on.
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- Chemical Name:
- BENZYLPENICILLIN POTASSIUM IMP.E (EP):PENICILLOIC ACIDS OF BENZYLPENICILLIN MM(CRM STANDARD)
- Structure:
- Chemical Name:
- (6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-[(2-ethoxy-2-oxoethoxy)iMino]acetyl]aMino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
- CAS:
- 79368-95-9
- MF:
- C18H19N5O7S2
- Structure:
- Chemical Name:
- 2-[[(Z)-[1-(2-aMino-4-thiazolyl)-2-[[[(2R,5RS)-5-Methyl-7-oxo-1,2,5,7-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl]Methyl]aMino]-2-oxoethylidene]aMino]oxy]acetic Acid
- CAS:
- 1335475-19-8
- MF:
- C15H17N5O6S2
- Structure:
- Chemical Name:
- Cefsulodin
- CAS:
- 62587-73-9
- MF:
- C22H20N4O8S2
- Chemical Name:
- GRAMICIDIN
- CAS:
- 1393-88-0
- Chemical Name:
- CEFTRIAXONE IMPURITY A
- Chemical Name:
- 6-EPIDOXYCYCLINE HYDROCHLORIDE
- Chemical Name:
- RIFAMPICIN QUINONE
- MF:
- C43H56N4O12
- Structure:
- Chemical Name:
- NEOMYCIN B
- CAS:
- 119-04-0
- MF:
- C23H46N6O13
- Structure:
- Chemical Name:
- Fosfomycin
- CAS:
- 23155-02-4
- MF:
- C3H7O4P
- Structure:
- Chemical Name:
- Cefazedone
- CAS:
- 56187-47-4
- MF:
- C18H15Cl2N5O5S3
- Structure:
- Chemical Name:
- TYROTHRICIN
- CAS:
- 1404-88-2
- MF:
- C6H13NO5
- Structure:
- Chemical Name:
- SULBENICILLIN
- CAS:
- 41744-40-5
- MF:
- C16H18N2O7S2
- Structure:
- Chemical Name:
- almecillin
- CAS:
- 87-09-2
- MF:
- C13H18N2O4S2
- Structure:
- Chemical Name:
- Cefazedone sodium salt
- CAS:
- 63521-15-3
- MF:
- C18H14Cl2N5NaO5S3
- Chemical Name:
- Carbenicillin Disodium Salt
- Structure:
- Chemical Name:
- Amikacin sulfate salt
- CAS:
- 149022-22-0
- MF:
- C22H45N5O17S
- Chemical Name:
- IVERMECTIN PREMIX
- Structure:
- Chemical Name:
- Cefdinir Related Compound A (10 mg) (2(R)-2-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-2-[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1Hfuro[3,4-d][1,3]thiazin-2-yl]acetic acid)
- CAS:
- 178422-42-9
- MF:
- C14H15N5O6S2
- Chemical Name:
- Clavulanate PotassiuM+Microcrystalline cellulose(1:1)
- Chemical Name:
- BENETHAMINE PENICILLIN
- Structure:
- Chemical Name:
- Methicillin Sodium Salt
- CAS:
- 132-92-3
- MF:
- C17H19N2NaO6S
- Structure:
- Chemical Name:
- Cephaloridine
- CAS:
- 50-59-9
- MF:
- C19H17N3O4S2
- Structure:
- Chemical Name:
- Cordycepin powder
- MF:
- C10H13N5O3
- Chemical Name:
- Chlortetracycline FEED GRADE
- Chemical Name:
- Penicillin G mixture
- Chemical Name:
- PENICILLIN V POTASSIUM USP(CRM STANDARD)
- Chemical Name:
- PENCILLIN G SODIUM USP(CRM STANDARD)
- Chemical Name:
- L-PHENETHICILLIN POTASSIUM USP(CRM STANDARD)
- Chemical Name:
- TICARCILLIN SODIUM EPT(CRM STANDARD)
- Chemical Name:
- Rifamycin Na
- Chemical Name:
- MeropeneM with SodiuM Carbonate
- Structure:
- Chemical Name:
- Sulfamethazine
- CAS:
- 35762-76-6
- MF:
- C6H9N3O2S
- Structure:
- Chemical Name:
- N-Demethyllincomycin
- CAS:
- 2256-16-8
- MF:
- C17H32N2O6S
- Structure:
- Chemical Name:
- Cefteram pivoxil
- CAS:
- 82547-81-7
- MF:
- C22H27N9O7S2
- Structure:
- Chemical Name:
- Cefroxadine
- CAS:
- 51762-05-1
- MF:
- C16H19N3O5S
- Chemical Name:
- Penicillin&StreptoMycin&NeoMycin solution,γ-Irradiated
- Structure:
- Chemical Name:
- Cefonicid
- CAS:
- 61270-58-4
- MF:
- C18H18N6O8S3
- Structure:
- Chemical Name:
- TROLEANDOMYCIN
- CAS:
- 2751-09-9
- MF:
- C41H67NO15
- Structure:
- Chemical Name:
- PENICILLIN V
- CAS:
- 87-08-1
- MF:
- C16H18N2O5S
- Structure:
- Chemical Name:
- MICRONOMICIN SULFATE
- CAS:
- 66803-19-8
- MF:
- C20H43N5O11S
- Structure:
- Chemical Name:
- KANAMYCIN
- CAS:
- 8063-07-8
- MF:
- C18H36N4O11
- Chemical Name:
- PENICILLIN G ALLERGY REAGENTS
- Structure:
- Chemical Name:
- viomycin
- CAS:
- 32988-50-4
- MF:
- C25H43N13O10
- Chemical Name:
- Cefadroxil Capsule
- Chemical Name:
- AMOXYCILLIN Sodium sterile IP/Bp
- Chemical Name:
- Quaternary oxytetracycline salt
- Chemical Name:
- 7-AMCA
- Structure:
- Chemical Name:
- Isochlortetracyclinehydrochloride
- CAS:
- 514-53-4
- MF:
- C22H23ClN2O8.ClH
- Chemical Name:
- Sodium oxolinate
- CAS:
- 1391-41-9
- Chemical Name:
- PENICILLIN V USP(CRM STANDARD)
- Chemical Name:
- PHENOXYMETHYLPENICILLIN POTASSIUM IMP. E (EP): PHENOXYMETHYLPENICILLOIC ACID MM(CRM STANDARD)
- Structure:
- Chemical Name:
- Ceftazidime sodium
- CAS:
- 73547-61-2
- MF:
- C22H23N6NaO7S2
- Structure:
- Chemical Name:
- FORTIMICIN
- CAS:
- 55779-06-1
- MF:
- C17H35N5O6
- Structure:
- Chemical Name:
- CYCLACILLIN (200 MG)
- CAS:
- 3485-14-1
- MF:
- C15H23N3O4S
- Chemical Name:
- RIFAMYCIN B
- Chemical Name:
- Penicillin G sodium buffered
- Chemical Name:
- Cefclidin
- Chemical Name:
- PENICILLIN G BENZATHINE USP(CRM STANDARD)
- Chemical Name:
- AZLOCILLIN SODIUM USP(CRM STANDARD)
- Chemical Name:
- BENETHAMINE PENICILLIN BP(CRM STANDARD)
- Chemical Name:
- 5-FORMAMIDE-1-(2-FORMYLOXYETHYL)PYRAZOLE
- MF:
- C7H9N3O3
- Chemical Name:
- CLOXACILLIN BENZATHINE USP(CRM STANDARD)
- Structure:
- Chemical Name:
- cefoxazole
- CAS:
- 36920-48-6
- MF:
- C21H18ClN3O7S
- Structure:
- Chemical Name:
- PHENETHICILLIN POTASSIUM SALT
- CAS:
- 132-93-4
- MF:
- C17H19KN2O5S
- Structure:
- Chemical Name:
- Ceftobiprole medocaril
- CAS:
- 376653-43-9
- MF:
- C26H26N8O11S2
- Structure:
- Chemical Name:
- 1,2-Pyrrolidinedicarboxylic acid, 4-[(Methylsulfonyl)oxy]-, 2-Methyl 1-[(4-nitrophenyl)Methyl] ester, (2S,4R)-
- CAS:
- 138324-82-0
- MF:
- C15H18N2O9S
- Chemical Name:
- Penicillin&StreptoMycin&AMphotericin B solution,γ-Irradiated
- Structure:
- Chemical Name:
- α-[[(Z)-2-(2-aMino-4-thiazolyl)-2-[(carboxyMethoxy)iMino]acetyl]aMino]-2-[(2R)-5-Methyl-7-oxo-1,2,5,7-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl]acetic Acid
- CAS:
- 1335475-08-5
- MF:
- C16H17N5O8S2
- Structure:
- Chemical Name:
- Cefamandole
- CAS:
- 34444-01-4
- MF:
- C18H18N6O5S2
- Structure:
- Chemical Name:
- KANAMYCIN
- CAS:
- 59-01-8
- MF:
- C18H36N4O11
- Structure:
- Chemical Name:
- TALAMPICILLIN
- CAS:
- 47747-56-8
- MF:
- C24H23N3O6S
- Structure:
- Chemical Name:
- Ceforanide
- CAS:
- 60925-61-3
- MF:
- C20H21N7O6S2
- Structure:
- Chemical Name:
- RIFAMYCIN SV
- CAS:
- 6998-60-3
- MF:
- C37H47NO12
- Structure:
- Chemical Name:
- Cefditoren
- CAS:
- 104145-95-1
- MF:
- C19H18N6O5S3
- Chemical Name:
- FLUCLOXACILLIN SODIUM EPF(CRM STANDARD)
- Structure:
- Chemical Name:
- Flomoxef sodium
- CAS:
- 92823-03-5
- MF:
- C15H19F2N6NaO7S2
- Structure:
- Chemical Name:
- Imipenem-Cilastatin sodium hydrate
- CAS:
- 92309-29-0
- MF:
- C28H43N5O9S2
- Chemical Name:
- FLORFENICOL POWDER
- Structure:
- Chemical Name:
- 6-Deoxy-4-epioxytetracycline
- CAS:
- 6543-77-7
- MF:
- C22H24N2O8
- Structure:
- Chemical Name:
- CARBENICILLIN PHENYL SODIUM
- CAS:
- 27025-49-6
- MF:
- C23H22N2O6S
- Structure:
- Chemical Name:
- NYSTATIN A1 TRIHYDRATE
- CAS:
- 34786-70-4
- MF:
- C47H75NO17
- Chemical Name:
- CHLOROAMPHENICOL VETRANAL
- Structure:
- Chemical Name:
- Neomycin
- CAS:
- 1404-04-2
- MF:
- C23H52N6O25S3
- Structure:
- Chemical Name:
- BACAMPICILLIN HYDROCHLORIDE
- CAS:
- 37661-08-8
- MF:
- C21H28ClN3O7S
- Structure:
- Chemical Name:
- rifamide
- CAS:
- 2750-76-7
- MF:
- C43H58N2O13
- Chemical Name:
- Clindmycin palmitate hydrochloride
- Chemical Name:
- Ceftetram
- Chemical Name:
- Penicillin G procaine/Potassium 3:1
- Chemical Name:
- Penicillin G potassium,non sterile
- Chemical Name:
- Oxytetracycline dihydrate injections
- Chemical Name:
- BENZATHINE BENZYLPENICILLIN EPB(CRM STANDARD)
- Chemical Name:
- 4-HYDROXY PHENOXYMETHYLPENICILLIN EPH(CRM STANDARD)
- Chemical Name:
- PIVMECILLINAM HYDROCHLORIDE EPP(CRM STANDARD)
- Chemical Name:
- PENICILLIN G PROCAINE USP(CRM STANDARD)
- Structure:
- Chemical Name:
- NAFCILLIN SODIUM SALT
- CAS:
- 985-16-0
- MF:
- C21H22N2O5S.Na
- Structure:
- Chemical Name:
- (6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-[(carboxyMethoxy)iMino]acetyl]aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
- CAS:
- 72701-01-0
- MF:
- C15H15N5O7S2
- Structure:
- Chemical Name:
- Cefbuperazone
- CAS:
- 76610-84-9
- MF:
- C22H29N9O9S2