3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo- Chemical Properties

Boiling point:

425.7±30.0 °C(Predicted)

Density 

1.145±0.06 g/cm3(Predicted)

storage temp. 

-20°C

pka

3.40±0.10(Predicted)

form 

liquid

color 

Yellow

InChI

InChI=1S/C11H21NO6/c1-11(2,3)18-10(15)12-4-5-16-6-7-17-8-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14)

InChIKey

OMBVJVWVXRNDSL-UHFFFAOYSA-N

SMILES

C(O)(=O)COCCOCCNC(=O)OC(C)(C)C

Safety Information

HS Code 

2918999090

3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo- Usage And Synthesis

Description

t-Boc-N-amido-PEG2-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

t-Boc-N-amido-PEG₂-CH₂CO₂H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG₂-CH₂CO₂H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

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