PROTAC FAK degrader 1 CAS#: 2301916-69-6

PROTAC FAK degrader 1 Basic information

Product Name:

PROTAC FAK degrader 1

Synonyms:

PROTAC FAK degrader 1
(2S,4R)-1-[(2S)-3,3-dimethyl-2-{3-[2-(4-{[4-({[3-(N-methylmethanesulfonamido)phenyl]methyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenoxy)ethoxy]propanamido}butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

CAS:

2301916-69-6

MF:

C47H56F3N9O8S2

MW:

996.13

Mol File:

Mol File

More

Less

PROTAC FAK degrader 1 Chemical Properties

Density: 1.368±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 200 mg/mL (200.78 mM)
pka: 14.07±0.40(Predicted)
form: Solid
color: White to off-white

More

Less

PROTAC FAK degrader 1 Usage And Synthesis

Description

PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM[1]. IC50: 6.5 nM (Focal adhesion kinase)DC50: 3 nM (Focal adhesion kinase)[1]

References

[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.

PROTAC FAK degrader 1Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Email: 3003855609@qq.com

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Email: sales@chemegen.com

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com

More

Less