PROTAC BRD4 Degrader-5 CAS#: 2409538-70-9

PROTAC BRD4 Degrader-5 Basic information

Product Name:

PROTAC BRD4 Degrader-5

Synonyms:

PROTAC BRD4 Degrader-5
(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamido}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

CAS:

2409538-70-9

MF:

C50H62ClN9O8S2

MW:

1016.67

Mol File:

Mol File

More

Less

PROTAC BRD4 Degrader-5 Chemical Properties

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 145 mg/mL (142.62 mM)
pka: 13.54±0.46(Predicted)
form: Solid
color: White to off-white
Water Solubility: Water: < 0.1 mg/mL (insoluble)

More

Less

PROTAC BRD4 Degrader-5 Usage And Synthesis

Uses

PROTAC BRD4 Degrader-5 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

IC 50

BRD4

References

[1] Mar? A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312. DOI:10.1021/acschembio.0c00285

PROTAC BRD4 Degrader-5Supplier

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com

More

Less