Basic information Safety Supplier Related

PROTAC IRAK4 degrader-1

Basic information Safety Supplier Related

PROTAC IRAK4 degrader-1 Basic information

Product Name:
PROTAC IRAK4 degrader-1
Synonyms:
  • PROTAC IRAK4 degrader-1
  • 2-{2-[(cyclopropylmethyl)amino]pyridin-4-yl}-N-{1-[4-({3-[4-({[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}methyl)-1H-imidazol-1-yl]propyl}carbamoyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-4-yl}-1,3-oxazole-4-carboxamide
  • PROTAC IRAK4
CAS:
2360533-90-8
MF:
C44H39F3N12O7
MW:
904.85
Mol File:
2360533-90-8.mol
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PROTAC IRAK4 degrader-1 Chemical Properties

Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
pka
10.74±0.40(Predicted)
form 
Solid
color 
White to yellow
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PROTAC IRAK4 degrader-1 Usage And Synthesis

Uses

PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1].

Biological Activity

PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1].

IC 50

IRAK4; Cereblon

References

[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

PROTAC IRAK4 degrader-1Supplier

Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Email
product02@bidepharm.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Email
cdnovell@163.com
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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PROTAC IRAK4 degrader-1(2360533-90-8)Related Product Information