PROTAC BRD4 Degrader-1 CAS#: 2133360-00-4

PROTAC BRD4 Degrader-1 Basic information

Product Name:

PROTAC BRD4 Degrader-1

Synonyms:

PROTAC BRD4 Degrader-1
Acetamide, 2-[2-[4-[[6-(3,5-dimethyl-4-isoxazolyl)-1,4-dihydro-1-methyl-2-oxo-4-phenyl-3(2H)-quinazolinyl]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
2-[2-(4-{[6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydroquinazolin-3-yl]methyl}-1H-1,2,3-triazol-1-yl)ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]acetamide

CAS:

2133360-00-4

MF:

C40H37N9O8

MW:

771.78

Mol File:

2133360-00-4.mol

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PROTAC BRD4 Degrader-1 Chemical Properties

Density: 1.52±0.1 g/cm3(Predicted)
pka: 10.68±0.40(Predicted)
form: Solid
color: White to off-white

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PROTAC BRD4 Degrader-1 Usage And Synthesis

Uses

PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression[1].

IC 50

BRD4 (BD1): 41.8 nM (IC₅₀)

References

[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228

PROTAC BRD4 Degrader-1Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Email: 3003855609@qq.com

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn

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