PROTAC FLT-3 degrader 1 CAS#: 2230826-81-8

PROTAC FLT-3 degrader 1 Basic information

Product Name:

PROTAC FLT-3 degrader 1

Synonyms:

PROTAC FLT-3 degrader 1
PROTACFLT-3degrader1/FLT3PROTAC
FLT-3 degrader 1
(2S,4R)-1-[(2S)-2-{3-[2-(2-{[4-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-7-thia-2,5-diazatricyclo[6.4.0.02,?]dodeca-1(8),3,5,9,11-pentaen-10-yl]oxy}ethoxy)ethoxy]propanamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

CAS:

2230826-81-8

MF:

C52H61N9O9S2

MW:

1020.23

Mol File:

2230826-81-8.mol

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PROTAC FLT-3 degrader 1 Chemical Properties

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 150 mg/mL (147.03 mM; Need ultrasonic)
form: Solid
pka: 12.59±0.70(Predicted)
color: White to light yellow

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PROTAC FLT-3 degrader 1 Usage And Synthesis

Biological Activity

PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].

References

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

PROTAC FLT-3 degrader 1Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Email: 3003855609@qq.com

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Email: sales@chemegen.com

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